Marquette vs DePaul Prediction, Picks & Odds | 16 Jan 2026

College Basketball Betting Preview: Marquette vs DePaul

The Marquette Golden Eagles battle the DePaul Blue Demons, with tip-off scheduled for 21:30 on Friday, January 16.

Don’t miss out on the chance to side with DePaul on the spread at -3.5. On the face of it, this seems a generous line and odds of -105 can be backed against Marquette.

Marquette Golden Eagles were defeated in their previous game. On the road, they suffered a 92-68 reverse against St. John's Red Storm.

DePaul Blue Demons lost on the road in their last game. UConn Huskies won 72-60.

Head-to-Head Statistics

Marquette had the edge in the most recent matchup between these teams. They recorded a 68-58 win over DePaul. Marquette have six straight victories against DePaul. They have won 8 of the 10 previous head-to-head matchups.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

View Full Standings

Marquette vs DePaul Prediction & Picks

We’ve broken down Marquette vs DePaul from every angle, offering our expert match prediction, expected final score, best player prop recommendations and a well-constructed bet builder.

Game Prediction

DePaul are available at odds of -105 when it comes to backing them against the spread in this college contest. The appealing -3.5 line could be covered with ease by the favorites and this looks like a value bet.

Incoming team news often impacts the betting lines and odds in significant ways. Our college hoops handicappers factor this in alongside recent form, while key stats are also carefully weighed to strengthen each basketball pick.

Key Marquette vs DePaul stats:

• The -3.5 line has been covered by DePaul in 4 of their last 5 games at home.
• The -3.5 line has been covered by DePaul in 7 of their last 10 games at home.
• The -3.5 line has been covered by DePaul in 2 consecutive games at home.
• The +3.5 line hasn’t been covered by Marquette in 7 consecutive games on the road.
• The +3.5 line hasn’t been covered by Marquette in 8 of their last 10 games on the road.
• The +3.5 line hasn’t been covered by Marquette in 13 of their last 20 games on the road.

DePaul -3.5 Probability

Based on the latest odds from the top sportsbooks, our pick carries a 51.3% chance of winning. Based on our in-depth research, we calculate the actual probability to be 55-60%. The bet can be recommended for this precise reason.

There’s the chance to sell points and that means moving the line until you’re happy with the wager. It means a riskier bet but a bigger return on the odds available.

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Our Game Prediction

DePaul -3.5 @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Jan 16, 01:55). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Nigel James Jr. Under 15.5 Points -120

Nigel James Jr. (Marquette) can be backed to record Under 15.5 points at -120. In our opinion, he might fall short when it comes to Player Points as we don’t think he will cover the line.

Latest Nigel James Jr. Player Prop Odds

Points

Over 15.5

-114

Under 15.5

-114

Assists

Over 3.5

-130

Under 3.5

-100

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RJ Smith Over 3.5 Rebounds +105

RJ Smith (DePaul) can be wagered to secure Over 3.5 rebounds at +105. Out of all the prop bets, we’re going Over when it comes to this Player Rebounds wager.

Latest RJ Smith Player Prop Odds

Points

Over 8.5

-130

Under 8.5

-100

Assists

Over 2.5

+115

Under 2.5

-149

Rebounds

Over 3.5

-100

Under 3.5

-130

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Marquette 71 - 78 DePaul

Should you want a bet that can land a monster return, then look no further than the correct score lines. Back the Blue Demons to win 78-71 and leverage a huge payout if this happens.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Marquette vs DePaul Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks’ betting odds have DePaul as -156 favorites for this college game, implying that they are 61% likely to win. The market suggests that Marquette are least likely to win at +128.

The spread is calculated to be 2.5, while total points comes in at 144.5. The advantage of the Totals is that you only have to choose from one of two options. If you want to back Over 144.5, it’s -115.

The good news is that you’ll find a strong selection of game lines and team props for most college contests. The best basketball betting sites provide a wide range of pre-game and in-game wagering options.

Moneyline

Marquette

+128

DePaul

-156

Point Spread

Marquette +2.5

-102

DePaul -2.5

-120

Total Points

Under 144.5

-105

Over 144.5

-115

Chase Ross is favorite when it comes to hitting the most buckets. You can get -106 that he goes Over 16.5 points and -122 when it comes to Under.

Chase Ross (Marquette)

Over 16.5

-106

Under 16.5

-122

Nigel James Jr. (Marquette)

Over 15.5

-114

Under 15.5

-114

CJ Gunn (DePaul)

Over 14.5

-100

Under 14.5

-130

Royce Parham (Marquette)

Over 11.5

-114

Under 11.5

-114

NJ Benson (DePaul)

Over 9.5

-130

Under 9.5

-100

RJ Smith (DePaul)

Over 8.5

-130

Under 8.5

-100

Nigel James Jr. (Marquette)

Over 3.5

-130

Under 3.5

-100

Chase Ross (Marquette)

Over 2.5

-114

Under 2.5

-114

RJ Smith (DePaul)

Over 2.5

+115

Under 2.5

-149

CJ Gunn (DePaul)

Over 1.5

-156

Under 1.5

+120

NJ Benson (DePaul)

Over 1.5

-100

Under 1.5

-130

Royce Parham (Marquette)

Over 0.5

-145

Under 0.5

+110

CJ Gunn (DePaul)

Over 4.5

+120

Under 4.5

-156

RJ Smith (DePaul)

Over 3.5

-100

Under 3.5

-130

It’s good to consider all wagering options when it comes to college basketball and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether the next shot will be a Two or a Three-pointer.

Latest regular season and playoff games stats.

Marquette Stats

DePaul Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 147.30 pts in the previous 10 games
• Game Totals on the Road: An average of 151.70 pts in the previous 10 games on the road
• Over 142.5: Covered in 7 of the previous 10 games
• Over 142.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 67.90 pts and allowed 79.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 69.40 pts and allowed 82.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 137.60 pts in the previous 10 games
• Game Totals at Home: An average of 146.40 pts in the previous 10 home games
• Over 142.5: Covered in 4 of the previous 10 games
• Over 142.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 68.00 pts and allowed 69.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 76.90 pts and allowed 69.50 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
St. John's	28-6	2773	2379	394	18-3	10-3	6W
Villanova	24-8	2469	2265	204	15-4	9-4	1L
Seton Hall	21-12	2321	2156	165	13-5	8-7	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Georgetown	16-18	2503	2479	24	10-8	6-10	1L
Creighton	15-17	2404	2401	3	11-6	4-11	1L
Providence	15-18	2815	2772	43	10-7	5-11	1L
Xavier	15-18	2586	2661	-75	13-7	2-11	1L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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