Niagara vs Duke Prediction, Picks & Odds | 21 Nov 2025

College Basketball Betting Preview: Niagara vs Duke

The Niagara Purple Eagles square off against the Duke Blue Devils, with tip-off scheduled for 19:00 on Friday, November 21.

Let's take a chance on the underdogs and wager Niagara with a +39.5 points start. They should be able to cover the line against Duke at odds of -110.

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Niagara Purple Eagles were defeated in their previous game. On the road, they suffered a 74-68 reverse against Le Moyne Dolphins.

Duke Blue Devils won their last game, beating Kansas Jayhawks at home. It was a 78-66 win.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	5-0	462	301	161	4-0	1-0	5W
Niagara	2-2	266	273	-7	1-0	1-2	1L

View Full Standings

Niagara vs Duke Prediction & Picks

Our Niagara vs Duke betting preview covers everything you need, including a key match prediction, correct score insight and a value-packed bet builder recommendation.

Game Prediction

The best bet could be Niagara at -110 on the spread. They have been given a +39.5 points start and should be able to stay relatively close to the big favorites in this college matchup.

The college hoops handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our basketball picks.

Key Niagara vs Duke stats:

• The +39.5 line has been covered by Niagara in 20 consecutive games on the road.
• The -39.5 line hasn’t been covered by Duke in 18 of their last 20 games at home.
• The -39.5 line hasn’t been covered by Duke in 8 of their last 10 games at home.
• The -39.5 line hasn’t been covered by Duke in 2 consecutive games.

Niagara +39.5 Probability

The top sportsbooks make it a 52.4% chance that our pick is settled as a winner. However, our cappers research has found that the actual probability is between 55-60%. That means we’re regarding it as a value bet.

If you’re searching for bigger odds when it comes to Niagara covering the line, then consider a Bet Builder. This allows you to load additional selections to your wager.

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Our Game Prediction

Niagara +39.5 @ -110 Bet Now

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Correct Score Prediction

Niagara 52 - 87 Duke

Rather than betting on Duke to win, there’s the option to try your luck when it comes to the correct score lines. Take a chance on a 87-52 triumph in their favor.

Niagara vs Duke Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

The Moneyline betting odds might not be available with some sportsbooks as there’s a big underdog in the form of Niagara. However, the Spread can provide some great alternative wagering options.

39.5 is the spread and 146.5 is the total points line. There is no denying the popularity of betting on the Totals. Those who wager Under 146.5 can get -110.

Whether you are betting pre-game or in-game, you can feast on a wide range of team props and game lines at the top basketball sportsbooks. The selections are practically endless, and it’s fantastic to have so many options.

Moneyline

Niagara

-

Duke

-

Point Spread

Niagara +39.5

-110

Duke -39.5

-110

Total Points

Under 146.5

-110

Over 146.5

-110

Prop bets don’t involve betting on a team to win and instead might look at a player’s individual performance. For example, the number of Points they might score or the number of Assists they might have.

Instead of focusing on the overall outcome, some bettors prefer to look at the college basketball micro betting lines. As the name suggests, it means placing short-term in-game wagers and this might include Next Field Goal, with the options being for a two-pointer or a three-pointer.

Latest regular season and playoff games stats.

Niagara Stats

Duke Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +39.5 Betting Line: Have covered the spread in the last 10 games
• +39.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -39.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -39.5 Betting Line at Home: Have covered the spread in 2 of the last 10 home games

Total Points

• Game Totals: An average of 140.00 pts in the previous 10 games
• Game Totals on the Road: An average of 139.30 pts in the previous 10 games on the road
• Over 146.5: Covered in 3 of the previous 10 games
• Over 146.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 67.40 pts and allowed 72.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 67.20 pts and allowed 72.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 154.00 pts in the previous 10 games
• Game Totals at Home: An average of 150.20 pts in the previous 10 home games
• Over 146.5: Covered in 6 of the previous 10 games
• Over 146.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 89.60 pts and allowed 64.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 85.50 pts and allowed 64.70 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	5-0	462	301	161	4-0	1-0	5W
NC State	4-0	403	279	124	4-0	0-0	4W
North Carolina	5-0	440	316	124	5-0	0-0	5W
Virginia	4-0	363	246	117	4-0	0-0	4W
Syracuse	4-0	326	213	113	3-0	1-0	4W
Virginia Tech	5-0	461	364	97	5-0	0-0	5W
SMU	5-0	460	370	90	5-0	0-0	5W
Stanford	4-0	350	281	69	4-0	0-0	4W
Louisville	4-0	412	284	128	4-0	0-0	4W
California	4-1	420	348	72	4-0	0-1	1W
Georgia Tech	4-1	355	315	40	4-0	0-1	1W
Clemson	4-1	423	293	130	4-0	0-1	1W
Notre Dame	4-1	418	338	80	4-0	0-1	1W
Miami	4-1	456	345	111	4-0	0-1	1W
Florida State	3-1	372	291	81	3-0	0-1	1W
Pittsburgh	4-2	430	383	47	4-0	0-2	1L
Wake Forest	3-2	445	383	62	3-0	0-2	1L
Boston College	3-2	352	313	39	2-1	1-1	2W

Metro Atlantic Athletic	Overall	PF	PA	N. Pts	Home	Away	Strk
Iona	4-0	351	304	47	3-0	1-0	4W
Quinnipiac	3-2	387	370	17	2-1	1-1	2W
Manhattan	3-2	423	407	16	2-0	1-2	1W
Fairfield	3-2	359	364	-5	2-0	1-2	2W
Marist	2-2	284	239	45	1-1	1-1	1L
Siena	2-2	279	259	20	1-1	1-1	2L
Niagara	2-2	266	273	-7	1-0	1-2	1L
Merrimack	2-3	348	390	-42	1-1	1-2	2W
Canisius	2-3	310	368	-58	2-0	0-3	1L
Sacred Heart	1-3	307	313	-6	1-0	0-3	3L
Saint Peter's	1-3	274	319	-45	1-0	0-3	2L
Mount St. Mary's	1-4	335	376	-41	0-1	1-3	2L
Rider	1-4	302	412	-110	1-0	0-4	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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