Northwestern vs DePaul Prediction, Picks & Odds | 14 Nov 2025

College Basketball Betting Preview: Northwestern vs DePaul

The Northwestern Wildcats face the DePaul Blue Demons, with tip-off scheduled for 20:30 on Friday, November 14.

Don’t miss out on the opportunity to side with Northwestern at -4.5 on the spread. On the face of it, this seems a more than generous line and -110 can be backed against DePaul.

Northwestern Wildcats won their previous game which was at home. It was a 110-63 triumph against Cleveland State Vikings.

DePaul Blue Demons lost when they last took to the court. They were turned over 66-53 at home to Buffalo Bulls.

Head-to-Head Statistics

Northwestern beat DePaul when the teams last met. It was a 84-64 scoreline. Northwestern have triumphed in their previous three matchups against DePaul. On the head-to-head front, it has been 4 wins out of 5.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Northwestern	15-19	2487	2447	40	11-9	4-10	1L

View Full Standings

Northwestern vs DePaul Prediction & Picks

Get the full betting picture for Northwestern vs DePaul, including a key match prediction, our best correct score selection, top player prop picks and a ready-made bet builder.

Game Prediction

We’re confident of backing the favorites to cover the -4.5 spread. This is a generous betting line and Northwestern look an awesome pick at odds of -110 for this college showdown.

Team news plays a key role in our basketball forecasts and we’re always tracking players with injury concerns. We also stay on top of the college hoops form guide, supported by detailed stats that help paint a clearer picture of what to expect.

Key Northwestern vs DePaul stats:

• The -4.5 line has been covered by Northwestern in 4 of their last 5 games.
• The -4.5 line has been covered by Northwestern in 7 of their last 10 games.
• The -4.5 line has been covered by Northwestern in 3 consecutive games.
• The +4.5 line hasn’t been covered by DePaul in 11 of their last 20 games.
• The +4.5 line hasn’t been covered by DePaul in 3 consecutive games against Northwestern.

Northwestern -4.5 Probability

Based on the latest odds from the top sportsbooks, our pick carries a 52.4% chance of winning. Based on our in-depth research, we calculate the actual probability to be closer to 60%. This is why we can recommend this college basketball bet.

If you’re searching for bigger odds when it comes to Northwestern covering the line, then consider a Bet Builder. This allows you to load additional selections to your wager.

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Our Game Prediction

Northwestern -4.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Nov 14, 12:07). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Nick Martinelli Under 8.5 Rebounds -149

Nick Martinelli (Northwestern) is available at -149 to rack up Under 8.5 rebounds. Let’s shoot for a relatively low total and take him to go under the Player Rebounds line.

Latest Nick Martinelli Player Prop Odds

Points

Over 19.5

-105

Under 19.5

-125

Assists

Over 1.5

-100

Under 1.5

-135

Rebounds

Over 7.5

-115

Under 7.5

-110

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Arrinten Page Under 1.5 Assists -222

Arrinten Page (Northwestern) can be wagered to total Under 1.5 assists at -222. He’s not guaranteed to cover the Player Assists line and we’re happy to take this bet.

Latest Arrinten Page Player Prop Odds

Points

Over 9.5

-135

Under 9.5

+105

Assists

Over 1.5

+145

Under 1.5

-200

Rebounds

Over 7.5

+115

Under 7.5

-149

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Northwestern 71 - 63 DePaul

There’s the chance to back the Wildcats in lots of different ways and this includes predicting the correct winning score. We’ll go for a 71-63 victory in their favor.

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Northwestern vs DePaul Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this college game, the sportsbooks’ Moneyline betting odds mean Northwestern are -238 favorites to win and that means a 70% chance of landing a victory. At +195, DePaul are regarded as having a lower probability of winning.

The spread is calculated to be 5.5, while total points comes in at 145.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. Those who wager Under 145.5 can get -105.

You can find a nice selection of game lines and team props for most college basketball matchups, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Northwestern

-238

DePaul

+195

Point Spread

Northwestern -5.5

-102

DePaul +5.5

-120

Total Points

Under 145.5

-105

Over 145.5

-115

In terms of hitting the most buckets, favorite Nick Martinelli is available at -105 to rack up Over 19.5 points. If you want to go Under, then -125 is available.

Nick Martinelli (Northwestern)

Over 19.5

-105

Under 19.5

-125

CJ Gunn (DePaul)

Over 14.5

-118

Under 14.5

-110

NJ Benson (DePaul)

Over 11.5

-110

Under 11.5

-120

Jayden Reid (Northwestern)

Over 10.5

-120

Under 10.5

-110

Arrinten Page (Northwestern)

Over 9.5

-135

Under 9.5

+105

Layden Blocker (DePaul)

Over 9.5

-100

Under 9.5

-130

Jayden Reid (Northwestern)

Over 3.5

-125

Under 3.5

-105

Layden Blocker (DePaul)

Over 3.5

-141

Under 3.5

+110

Nick Martinelli (Northwestern)

Over 1.5

-100

Under 1.5

-135

CJ Gunn (DePaul)

Over 1.5

-130

Under 1.5

-100

Arrinten Page (Northwestern)

Over 1.5

+145

Under 1.5

-200

NJ Benson (DePaul)

Over 0.5

-250

Under 0.5

+180

NJ Benson (DePaul)

Over 8.5

+110

Under 8.5

-145

Nick Martinelli (Northwestern)

Over 7.5

-115

Under 7.5

-110

Arrinten Page (Northwestern)

Over 7.5

+115

Under 7.5

-149

CJ Gunn (DePaul)

Over 4.5

+105

Under 4.5

-141

Layden Blocker (DePaul)

Over 3.5

+105

Under 3.5

-135

Jayden Reid (Northwestern)

Over 2.5

-120

Under 2.5

-110

Micro betting provides a rollercoaster ride for college basketball bettors. It can be great to enjoy the live lines, with the opportunity to bet on the Next Field Goal. Watch the live action before deciding which way to go.

Latest regular season and playoff games stats.

Northwestern Stats

DePaul Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 134.60 pts in the previous 10 games
• Game Totals on the Road: An average of 141.70 pts in the previous 10 games on the road
• Over 141.5: Covered in 2 of the previous 10 games
• Over 141.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 73.40 pts and allowed 61.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 69.80 pts and allowed 71.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 147.00 pts in the previous 10 games
• Game Totals at Home: An average of 139.40 pts in the previous 10 home games
• Over 141.5: Covered in 6 of the previous 10 games
• Over 141.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 73.00 pts and allowed 74.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 68.50 pts and allowed 70.90 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
St. John's	28-6	2773	2379	394	18-3	10-3	6W
Villanova	24-8	2469	2265	204	15-4	9-4	1L
Seton Hall	21-12	2321	2156	165	13-5	8-7	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Georgetown	16-18	2503	2479	24	10-8	6-10	1L
Creighton	15-17	2404	2401	3	11-6	4-11	1L
Providence	15-18	2815	2772	43	10-7	5-11	1L
Xavier	15-18	2586	2661	-75	13-7	2-11	1L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

Big Ten	Overall	PF	PA	N. Pts	Home	Away	Strk
Michigan	31-3	2952	2353	599	19-2	12-1	1L
Nebraska	26-6	2473	2119	354	19-3	7-3	1L
Michigan State	25-7	2526	2189	337	17-3	8-4	2L
Purdue	27-8	2858	2455	403	16-5	11-3	4W
Illinois	24-8	2700	2234	466	15-6	9-2	1L
Wisconsin	24-10	2822	2581	241	16-2	8-8	1L
UCLA	23-11	2643	2414	229	18-3	5-8	1L
Ohio State	21-12	2633	2402	231	15-5	6-7	1L
Iowa	21-12	2482	2177	305	17-3	4-9	1L
Indiana	18-14	2501	2309	192	15-6	3-8	2L
USC	18-14	2515	2494	21	11-7	7-7	8L
Washington	16-17	2545	2430	115	11-6	5-11	1L
Minnesota	15-17	2241	2193	48	13-8	2-9	1L
Northwestern	15-19	2487	2447	40	11-9	4-10	1L
Rutgers	14-19	2329	2479	-150	11-7	3-12	1L
Oregon	12-20	2267	2366	-99	10-10	2-10	1L
Penn State	12-20	2358	2539	-181	10-10	2-10	3L
Maryland	12-21	2300	2527	-227	9-8	3-13	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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