Notre Dame vs Louisville Prediction, Picks & Odds | 04 Feb 2026

College Basketball Betting Preview: Notre Dame vs Louisville

The Notre Dame Fighting Irish face the Louisville Cardinals, with tip-off scheduled for 19:00 on Wednesday, February 4.

Wagering on the totals provides lots of value at -110. The line is set at 153.5 and we’d be surprised if Notre Dame and Louisville’ combined points total exceeds that amount.

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Notre Dame Fighting Irish suffered a defeat in their previous game. A 86-72 scoreline occurred on the road against Syracuse Orange.

Louisville Cardinals won their last game which was at home. It was a 88-74 triumph against SMU Mustangs.

Head-to-Head Statistics

Louisville had the edge in the most recent matchup between these teams. They recorded a 75-60 win over Notre Dame. The previous 10 games featuring these teams have resulted in six Louisville victories.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Louisville	15-6	1808	1480	328	11-2	4-4	1W
Notre Dame	11-11	1627	1588	39	9-4	2-7	2L

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Notre Dame vs Louisville Prediction & Picks

Gear up for Notre Dame vs Louisville with our betting guide, featuring an expert match prediction, scoreline advice and a hand-picked bet builder. Explore each section below for detailed insights.

Game Prediction

Let’s go Under the 153.5 points total as we think this number is unlikely to be reached in this college showdown. The two teams could well end up falling short and -110 can be backed.

The college hoops handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our basketball picks.

Key Notre Dame vs Louisville stats:

• The 153.5 line hasn’t been covered in 14 of the last 20 Notre Dame games.
• The 153.5 line hasn’t been covered in 6 of the last 10 Notre Dame games.
• The 153.5 line hasn’t been covered in 11 of the last 20 Louisville games at home.
• The 153.5 line hasn’t been covered in the last 9 games between these teams.

Under 153.5 Probability

The top betting apps imply that our pick has a 52.4% prospect of delivering a return. After careful examination, our cappers have this probability somewhere between 55-60%. This college basketball wager can therefore be backed with confidence.

For a bigger payout, many bettors will include their Under pick on the Totals with other selections. A Bet Builder is perfect for combining all your predictions.

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Our Game Prediction

Under 153.5 Points @ -110 Bet Now

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Correct Score Prediction

Notre Dame 62 - 84 Louisville

There are lots of different betting angles including the chance to back Louisville on the correct score lines. For example, a 84-62 victory in their favor is available at massive odds.

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Notre Dame vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks are taking no chances with their Moneyline odds of -3333 about Louisville which reflects they have a 97% chance of winning this college game. Notre Dame are regarded as a long shot to win and you can currently back them at +1200.

The spread currently stands at 17.5 and the total points line is 153.5. There are many ways to bet on basketball including the Totals. If you want to bet Under 153.5, there are odds of -110.

The top basketball sportsbooks offer a huge selection of game lines and team props when it comes to most college games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Notre Dame

+1200

Louisville

-3333

Point Spread

Notre Dame +17.5

-114

Louisville -17.5

-106

Total Points

Under 153.5

-110

Over 153.5

-110

The gambling sites will have player props available for each game. Check out the various betting odds and take a view on whether a player’s Total Points, Three-Pointers, Blocks or Steals will hit over or under a certain line.

Micro betting is an exciting way to wager on college basketball. There are many live lines and it’s a simple case of predicting what is going to happen. Next Field Goal, where you select if the shot will be a two or three-pointer are among the options.

Latest regular season and playoff games stats.

Notre Dame Stats

Louisville Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +17.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +17.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -17.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -17.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 147.00 pts in the previous 10 games
• Game Totals on the Road: An average of 139.80 pts in the previous 10 games on the road
• Over 153.5: Covered in 4 of the previous 10 games
• Over 153.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 69.90 pts and allowed 77.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 65.80 pts and allowed 74.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 151.90 pts in the previous 10 games
• Game Totals at Home: An average of 155.20 pts in the previous 10 home games
• Over 153.5: Covered in 6 of the previous 10 games
• Over 153.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 80.30 pts and allowed 71.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 88.10 pts and allowed 67.10 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	21-1	1851	1399	452	13-0	8-1	10W
Virginia	19-3	1832	1502	330	12-1	7-2	3W
Clemson	18-4	1682	1420	262	13-1	5-3	2W
North Carolina	18-4	1829	1553	276	14-0	4-4	4W
Miami	17-5	1863	1542	321	12-3	5-2	1L
NC State	17-6	1974	1666	308	10-4	7-2	5W
California	16-6	1722	1553	169	14-2	2-4	1W
Louisville	15-6	1808	1480	328	11-2	4-4	1W
Virginia Tech	16-7	1840	1703	137	13-2	3-5	1L
SMU	15-7	1902	1712	190	13-2	2-5	2L
Stanford	14-8	1669	1616	53	9-5	5-3	4L
Syracuse	13-10	1744	1626	118	10-4	3-6	1L
Wake Forest	11-11	1761	1707	54	8-5	3-6	4L
Notre Dame	11-11	1627	1588	39	9-4	2-7	2L
Georgia Tech	11-11	1639	1627	12	10-6	1-5	3L
Florida State	10-12	1777	1751	26	9-6	1-6	2W
Boston College	9-13	1479	1503	-24	8-7	1-6	3L
Pittsburgh	9-14	1632	1631	1	7-7	2-7	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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