Notre Dame vs Louisville Prediction, Picks & Odds | 04 Feb 2026

College Basketball Betting Preview: Notre Dame vs Louisville

The Notre Dame Fighting Irish face the Louisville Cardinals, with tip-off scheduled for 19:00 on Wednesday, February 4.

Wagering on the totals provides lots of value at -110. The line is set at 153.5 and we’d be surprised if Notre Dame and Louisville’ combined points total exceeds that amount.

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Notre Dame Fighting Irish suffered a defeat in their previous game. A 86-72 scoreline occurred on the road against Syracuse Orange.

Louisville Cardinals won their last game which was at home. It was a 88-74 triumph against SMU Mustangs.

Head-to-Head Statistics

Louisville had the edge in the most recent matchup between these teams. They recorded a 75-60 win over Notre Dame. The previous 10 games featuring these teams have resulted in six Louisville victories.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Louisville	18-6	2090	1702	388	13-2	5-4	4W
Notre Dame	11-13	1771	1746	25	9-5	2-8	4L

View Full Standings

Notre Dame vs Louisville Prediction & Picks

Prepare for Notre Dame vs Louisville with our expert betting guide featuring a trusted match prediction, likely scoreline, key player props and a well-crafted bet builder.

Game Prediction

Let’s go Under the 153.5 points total as we think this number is unlikely to be reached in this college showdown. The two teams could well end up falling short and -110 can be backed.

The college hoops handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our basketball picks.

Key Notre Dame vs Louisville stats:

• The 153.5 line hasn’t been covered in 14 of the last 20 Notre Dame games.
• The 153.5 line hasn’t been covered in 6 of the last 10 Notre Dame games.
• The 153.5 line hasn’t been covered in 11 of the last 20 Louisville games at home.
• The 153.5 line hasn’t been covered in the last 9 games between these teams.

Under 153.5 Probability

The top betting apps imply that our pick has a 52.4% prospect of delivering a return. After careful examination, our cappers have this probability somewhere between 55-60%. This college basketball wager can therefore be backed with confidence.

For a bigger payout, many bettors will include their Under pick on the Totals with other selections. A Bet Builder is perfect for combining all your predictions.

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Our Game Prediction

Under 153.5 Points @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (23:55, 03 February 2026). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Isaac McKneely Under 11.5 Points -130

Isaac McKneely (Louisville) can be backed to record Under 11.5 points at -130. We are keen to take the selection that he fails to cover this total when it comes to Player Points.

Latest Isaac McKneely Player Prop Odds

Points

Over 11.5

-100

Under 11.5

-130

Assists

Over 1.5

+170

Under 1.5

-222

Rebounds

Over 2.5

-135

Under 2.5

-100

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Braeden Shrewsberry Under 1.5 Assists -145

Braeden Shrewsberry (Notre Dame) is available at -145 to total Under 1.5 assists. He might struggle to reach the Player Assists line this time around, with this pick looking really appealing.

Latest Braeden Shrewsberry Player Prop Odds

Points

Over 11.5

-118

Under 11.5

-110

Assists

Over 1.5

+110

Under 1.5

-145

Rebounds

Over 2.5

-161

Under 2.5

+120

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Notre Dame 62 - 84 Louisville

There are lots of different betting angles including the chance to back Louisville on the correct score lines. For example, a 84-62 victory in their favor is available at massive odds.

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Notre Dame vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks are taking no chances with their Moneyline odds of -3333 about Louisville which reflects they have a 97% chance of winning this college game. Notre Dame are regarded as a long shot to win and you can currently back them at +1280.

The spread currently stands at 18.5 and the total points line is 155.5. There are many ways to bet on basketball including the Totals. If you want to bet Under 155.5, there are odds of -105.

The top basketball sportsbooks offer a huge selection of game lines and team props when it comes to most college games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Notre Dame

+1280

Louisville

-3333

Point Spread

Notre Dame +18.5

-115

Louisville -18.5

-105

Total Points

Under 155.5

-105

Over 155.5

-115

Ryan Conwell is the favorite to score most points. He is priced at -115 to score Over 18.5 points. Alternatively, you can back Under at -110.

Ryan Conwell (Louisville)

Over 18.5

-115

Under 18.5

-110

Mikel Brown Jr. (Louisville)

Over 15.5

-118

Under 15.5

-110

Jalen Haralson (Notre Dame)

Over 15.5

-110

Under 15.5

-118

Braeden Shrewsberry (Notre Dame)

Over 11.5

-118

Under 11.5

-110

J'Vonne Hadley (Louisville)

Over 11.5

-100

Under 11.5

-130

Isaac McKneely (Louisville)

Over 11.5

-100

Under 11.5

-130

Sananda Fru (Louisville)

Over 9.5

-130

Under 9.5

-100

Carson Towt (Notre Dame)

Over 6.5

-105

Under 6.5

-125

Mikel Brown Jr. (Louisville)

Over 4.5

-130

Under 4.5

-100

Ryan Conwell (Louisville)

Over 2.5

-125

Under 2.5

-105

Jalen Haralson (Notre Dame)

Over 2.5

+105

Under 2.5

-141

Braeden Shrewsberry (Notre Dame)

Over 1.5

+110

Under 1.5

-145

J'Vonne Hadley (Louisville)

Over 1.5

-141

Under 1.5

+110

Isaac McKneely (Louisville)

Over 1.5

+170

Under 1.5

-222

Sananda Fru (Louisville)

Over 1.5

-105

Under 1.5

-120

Carson Towt (Notre Dame)

Over 1.5

+110

Under 1.5

-145

Carson Towt (Notre Dame)

Over 7.5

-135

Under 7.5

+105

Sananda Fru (Louisville)

Over 5.5

-130

Under 5.5

-100

Ryan Conwell (Louisville)

Over 4.5

-149

Under 4.5

+115

J'Vonne Hadley (Louisville)

Over 4.5

-154

Under 4.5

+120

Jalen Haralson (Notre Dame)

Over 3.5

-154

Under 3.5

+120

Mikel Brown Jr. (Louisville)

Over 2.5

-149

Under 2.5

+115

Braeden Shrewsberry (Notre Dame)

Over 2.5

-161

Under 2.5

+120

Isaac McKneely (Louisville)

Over 2.5

-135

Under 2.5

-100

Micro betting is an exciting way to wager on college basketball. There are many live lines and it’s a simple case of predicting what is going to happen. Next Field Goal, where you select if the shot will be a two or three-pointer are among the options.

Latest regular season and playoff games stats.

Notre Dame Stats

Louisville Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +17.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +17.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -17.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -17.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 147.00 pts in the previous 10 games
• Game Totals on the Road: An average of 139.80 pts in the previous 10 games on the road
• Over 153.5: Covered in 4 of the previous 10 games
• Over 153.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 69.90 pts and allowed 77.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 65.80 pts and allowed 74.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 151.90 pts in the previous 10 games
• Game Totals at Home: An average of 155.20 pts in the previous 10 home games
• Over 153.5: Covered in 6 of the previous 10 games
• Over 153.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 80.30 pts and allowed 71.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 88.10 pts and allowed 67.10 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	21-2	1919	1470	449	13-0	8-2	1L
Virginia	20-3	1904	1561	343	13-1	7-2	4W
Clemson	20-4	1825	1539	286	13-1	7-3	4W
North Carolina	19-4	1900	1621	279	15-0	4-4	5W
Miami	18-5	1937	1610	327	12-3	6-2	1W
Louisville	18-6	2090	1702	388	13-2	5-4	4W
NC State	18-7	2133	1857	276	11-4	7-3	1L
California	17-7	1867	1715	152	15-3	2-4	1L
SMU	16-7	1988	1779	209	13-2	3-5	1W
Virginia Tech	16-8	1913	1785	128	13-2	3-6	2L
Stanford	15-9	1828	1754	74	10-6	5-3	1W
Syracuse	13-11	1803	1698	105	10-4	3-7	2L
Florida State	11-12	1859	1830	29	9-6	2-6	3W
Wake Forest	11-12	1841	1795	46	8-6	3-6	5L
Notre Dame	11-13	1771	1746	25	9-5	2-8	4L
Georgia Tech	11-13	1796	1812	-16	10-6	1-7	5L
Boston College	9-14	1547	1577	-30	8-8	1-6	4L
Pittsburgh	9-15	1699	1717	-18	7-8	2-7	3L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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