Oregon vs USC Prediction, Picks & Odds | 21 Feb 2026

College Basketball Betting Preview: Oregon vs USC

The Oregon Ducks go up against the USC Trojans, with tip-off scheduled for 16:00 on Saturday, February 21.

It’s awesome to see USC with a -5.5 line on the spread at odds of -105 as we’re expecting a bigger margin of victory against Oregon.

Oregon Ducks lost their previous game, being beaten at home to Minnesota Golden Gophers 61-44.

USC Trojans were defeated last time out. They were beaten at home to Illinois Fighting Illini by a 101-65 scoreline.

Head-to-Head Statistics

USC won the most recent matchup between these teams. A 82-77 victory was registered against Oregon. Oregon have won six of the previous 10 H2H meetings.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
USC	18-8	2097	1997	100	11-4	7-4	2L
Oregon	9-17	1850	1933	-83	8-9	1-8	1L

View Full Standings

Oregon vs USC Prediction & Picks

We cover the key Oregon vs USC betting angles, showcasing our expert match prediction, correct score selection and a bet builder tailored for the best value.

Game Prediction

USC should be taken against the spread at -5.5 with our pick being for the favorites to achieve a comfortable margin of victory in this college matchup. Back them at the odds of -105 that are available.

The college hoops handicappers at Sportsgambler.com always keep close tabs on team news as it develops. We also rely on recent form and key stats to help shape our basketball picks and guide the final call.

Key Oregon vs USC stats:

• The +5.5 line hasn’t been covered by Oregon in 8 of their last 10 games.
• The +5.5 line hasn’t been covered by Oregon in 12 of their last 20 games.

USC -5.5 Probability

According to the latest betting odds, our pick has a 51.3% chance of winning. Taking all factors into consideration, our analysts think there’s a stronger chance of success and have a probability interval between 55-60%. This is why we can recommend this college basketball bet.

If you’re hunting for tastier odds, then a Bet Builder could be the perfect way to go. Combine USC to cover the line with other picks until you’re happy with the overall price.

Find top value before betting. Our guide includes the latest free bets and sign-up bonuses from trusted sites.

Our Game Prediction

USC -5.5 @ -105 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Feb 20, 20:02). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Oregon 71 - 79 USC

Should you want a bet that can land a monster return, then look no further than the correct score lines. Back the Trojans to win 79-71 and leverage a huge payout if this happens.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Oregon vs USC Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have USC at -263 when it comes to the Moneyline betting, implying the favorites are 72% likely to win this game according to the latest odds. If you’re looking for an alternative angle, Oregon are trading at +210.

The spread is currently 5.5, with the total points line at 146.5. Basketball bettors love the chance to get an alternative angle by going for a Total wager. If you're keen on Over 146.5, this selection is available at -110.

If you’re planning to place a bet on a college hoops matchup, visit the top basketball betting sites and check out the many available game lines and team props. Find the lines which are the most attractive.

Moneyline

Oregon

+210

USC

-263

Point Spread

Oregon +5.5

-110

USC -5.5

-110

Total Points

Under 146.5

-110

Over 146.5

-110

Prop bets don’t involve betting on a team to win and instead might look at a player’s individual performance. For example, the number of Points they might score or the number of Assists they might have.

It’s possible to use stats to your advantage when it comes to college basketball micro betting, especially if you’re predicting outcomes such as the Next Field Goal. Check out the live player, score and team props to see if you can find an angle.

Latest regular season and playoff games stats.

Oregon Stats

USC Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 138.40 pts in the previous 10 games
• Game Totals on the Road: An average of 148.50 pts in the previous 10 games on the road
• Over 144.5: Covered in 5 of the previous 10 games
• Over 144.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 62.30 pts and allowed 76.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 69.30 pts and allowed 79.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 152.10 pts in the previous 10 games
• Game Totals at Home: An average of 153.00 pts in the previous 10 home games
• Over 144.5: Covered in 7 of the previous 10 games
• Over 144.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 74.80 pts and allowed 77.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 78.70 pts and allowed 74.30 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	Overall	PF	PA	N. Pts	Home	Away	Strk
Michigan	25-1	2356	1788	568	15-1	10-0	11W
Nebraska	22-4	2036	1706	330	16-2	6-2	1L
Illinois	22-5	2290	1838	452	14-4	8-1	2W
Purdue	21-5	2146	1806	340	14-3	7-2	1L
Michigan State	21-5	2052	1726	326	15-2	6-3	1W
Iowa	19-7	1981	1674	307	15-2	4-5	1W
Wisconsin	18-8	2161	1976	185	13-2	5-6	1L
USC	18-8	2097	1997	100	11-4	7-4	2L
UCLA	17-9	2007	1844	163	14-2	3-7	2L
Ohio State	17-9	2110	1908	202	12-5	5-4	1W
Indiana	17-9	2089	1855	234	14-3	3-6	1L
Washington	13-13	1998	1883	115	9-5	4-8	1W
Minnesota	12-14	1835	1767	68	10-7	2-7	1W
Rutgers	11-15	1835	1963	-128	10-6	1-9	2W
Northwestern	11-16	2002	1972	30	9-8	2-8	1W
Penn State	11-16	2033	2139	-106	9-9	2-7	2L
Maryland	10-16	1859	2033	-174	8-6	2-10	2L
Oregon	9-17	1850	1933	-83	8-9	1-8	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

Top Basketball Pages