San Francisco vs Santa Clara Prediction, Picks & Odds | 28 Jan 2026

College Basketball Betting Preview: San Francisco vs Santa Clara

The San Francisco Dons battle the Santa Clara Broncos, with tip-off scheduled for 23:00 on Wednesday, January 28.

Santa Clara are capable of covering the -9.5 line when they go up against San Francisco. We’re confident of a strong showing and a bet against the spread could be the best play at -120.

San Francisco Dons were beaten in their previous game and this was on the road. Gonzaga Bulldogs claimed a 68-66 win.

Santa Clara Broncos triumphed in their last game. It was on the road where San Diego Toreros were beaten 85-73.

Head-to-Head Statistics

The last matchup between Santa Clara and San Francisco saw the former win. It was a 77-54 scoreline. We’ve seen six San Francisco wins in the past 10 meetings between the teams.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Santa Clara	26-8	2817	2463	354	16-3	10-5	1L
San Francisco	17-16	2464	2414	50	11-6	6-10	1L

View Full Standings

San Francisco vs Santa Clara Prediction & Picks

Our San Francisco vs Santa Clara betting preview covers everything you need, including a key match prediction, correct score insight and a value-packed bet builder recommendation.

Game Prediction

Santa Clara really stand out in this college contest. Back them at -9.5 on the spread with the confidence that the betting favorites cover the line at -120.

Our basketball predictions are always well-researched, starting with a combination of the latest college hoops team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key San Francisco vs Santa Clara stats:

• The -9.5 line has been covered by Santa Clara in 4 of their last 5 games at home.
• The -9.5 line has been covered by Santa Clara in 6 of their last 10 games.

Santa Clara -9.5 Probability

Based on the odds from the top betting sites, there’s a 54.6% likelihood of our pick delivering a return. However, our cappers think that the probability is close to 60% taking all factors into consideration. This college basketball wager can therefore be backed with confidence.

In the quest to secure bigger odds, there’s the possibility of moving the line. There are plenty of choices when it comes to doing this, so you can choose the option that suits you.

Get ahead of the game by checking our latest guide full of betting offers, welcome bonuses, and free bet deals.

Our Game Prediction

Santa Clara -9.5 @ -120 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Jan 28, 03:57). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

San Francisco 67 - 79 Santa Clara

If you want to take a chance on a correct score, then Santa Clara to enjoy a 79-67 win could be along the right lines. There are enormous odds for this particular outcome.

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San Francisco vs Santa Clara Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

According to the Moneyline betting odds, Santa Clara are red-hot -588 favorites with the sportsbooks and that means a 85% chance of winning this college game. San Francisco are regarded as a long shot to win and you can currently back them at +430.

The spread currently stands at 9.5 and the total points line is 150.5. A Total bet is always available and can often provide value selections. If you fancy Under 150.5, then the odds are -106.

If you’re planning to place a bet on a college basketball matchup, head to the top betting apps and explore the wide range of team props and game lines. Look for the lines that offer the most value.

Moneyline

San Francisco

+430

Santa Clara

-588

Point Spread

San Francisco +9.5

-102

Santa Clara -9.5

-120

Total Points

Under 150.5

-106

Over 150.5

-114

If you have a view on Total Points, Three-Pointers, Assists, Double-Doubles or Triple-Doubles, then the player prop betting could be up your street. It’s a great way of wagering on individual performance.

You don’t have to wait for the final outcome when it comes to college basketball micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Latest regular season and playoff games stats.

San Francisco Stats

Santa Clara Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 145.00 pts in the previous 10 games
• Game Totals on the Road: An average of 142.10 pts in the previous 10 games on the road
• Over 151.5: Covered in 3 of the previous 10 games
• Over 151.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 75.10 pts and allowed 69.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 70.80 pts and allowed 71.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 158.30 pts in the previous 10 games
• Game Totals at Home: An average of 149.30 pts in the previous 10 home games
• Over 151.5: Covered in 8 of the previous 10 games
• Over 151.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 86.40 pts and allowed 71.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 82.00 pts and allowed 67.30 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

West Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Gonzaga	30-3	2809	2178	631	20-0	10-3	2W
Saint Mary's	27-5	2502	2066	436	18-1	9-4	1L
Santa Clara	26-8	2817	2463	354	16-3	10-5	1L
Seattle	20-13	2373	2211	162	15-5	5-8	1L
Pacific	18-15	2399	2271	128	13-3	5-12	1L
Oregon State	17-16	2347	2447	-100	13-8	4-8	1L
San Francisco	17-16	2464	2414	50	11-6	6-10	1L
Loyola Marymount	15-17	2376	2306	70	10-10	5-7	2L
Portland	14-19	2426	2582	-156	12-6	2-13	1L
San Diego	12-21	2458	2570	-112	9-8	3-13	1L
Washington State	11-20	2435	2495	-60	9-8	2-12	4L
Pepperdine	9-23	2312	2546	-234	7-10	2-13	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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