Siena vs Duke Prediction, Picks & Odds | 19 Mar 2026

College Basketball Betting Preview: Siena vs Duke

No. 16 Siena Saints square off against No. 1 Duke Blue Devils in this NCAA Tournament First Round matchup at Bon Secours Wellness Arena in Greenville, South Carolina, with tip-off scheduled for 14:50 on Thursday, March 19.

Siena might be the underdogs but +27.5 looks too big on the spread. We’re keen to snap up the -102 that the betting line is covered against Duke.

The Siena Saints (23-11, 3rd in the MAAC) are coming off a 64-54 road victory against the Merrimack Warriors.

The Duke Blue Devils (32-2, 1st in the ACC) won their last game, beating the Virginia Cavaliers 74-70 at home.

NCAAB Regular Season	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	32-2	2798	2147	651	21-0	11-2	11W
Siena	23-11	2398	2233	165	11-4	12-7	4W

View Full Standings

Siena vs Duke Prediction & Picks

Get ahead of the game with our Siena vs Duke betting rundown, featuring our trusted match prediction, likely score outcome, standout player prop plays and a fully loaded bet builder.

Game Prediction

Siena have been given a sizeable +27.5 on the spread and we’re looking to take advantage. Back the -102 that the underdogs avoid a big loss in this college showdown.

The basketball picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every college hoops pick.

Key Siena vs Duke stats:

• The +27.5 line has been covered by Siena in 20 consecutive games.
• The -27.5 line hasn’t been covered by Duke in 4 consecutive games.
• The -27.5 line hasn’t been covered by Duke in 15 of their last 20 games.
• The -27.5 line hasn’t been covered by Duke in 7 of their last 10 games.

Siena +27.5 Probability

According to the top betting apps, there’s a 50.5% likelihood of our pick delivering a return. However, our analysts have this number closer to 60% based on their in-depth research. This is why we regard this as a value bet.

There’s the option to move the line for your point spread pick and this enables bettors to get bigger odds. If you’re prepared for additional risk, you can get more bang for your buck.

Explore the latest free bet promotions and welcome bonuses in our expert betting guide, updated with the best offers.

Our Game Prediction

Siena +27.5 @ -102 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 18, 19:02). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Gavin Doty Over 15.5 Points +103

Gavin Doty (Siena) can be wagered to score Over 15.5 points at +103. He looks like a solid bet to cover the Player Points line and we’re confident with this wager.

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Dame Sarr Over 4.5 Rebounds -122

Dame Sarr (Duke) can be wagered to total Over 4.5 rebounds at -122. The Player Rebounds line looks really attractive when it comes to having an Overs bet.

Latest Dame Sarr Player Prop Odds

Points

Over 8.5

-116

Under 8.5

-111

Rebounds

Over 4.5

-128

Under 4.5

-101

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Siena 59 - 84 Duke

Rather than betting on Duke to win, there’s the option to try your luck when it comes to the correct score lines. Take a chance on a 84-59 triumph in their favor.

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Siena vs Duke Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

It’s no surprise to find the Moneyline either uncompetitive or not available with many sportsbooks. However, there is a spread where favorites Duke and their opponents feature and bettors can work out where the value lies.

The spread is 27.5 and the total points line is currently 135.5. The advantage of the Totals is that you only have to choose from one of two options. If you're keen on Over 135.5, this selection is available at -115.

College basketball fans are spoiled for choice with the wide range of team props and game lines available for every matchup on the schedule. Visit the top sportsbooks to find the best value picks.

Moneyline

Siena

-

Duke

-

Point Spread

Siena +27.5

-102

Duke -27.5

-120

Total Points

Under 135.5

-105

Over 135.5

-115

In terms of landing the most baskets, favorite Cameron Boozer is available at -119 to rack up Over 22.5 points. If you want to go Under, then -109 is available.

Cameron Boozer (Duke)

Over 22.5

-119

Under 22.5

-109

Gavin Doty (Siena)

Over 15.5

+103

Under 15.5

-133

Isaiah Evans (Duke)

Over 14.5

-123

Under 14.5

-105

Cayden Boozer (Duke)

Over 10.5

-114

Under 10.5

-114

Dame Sarr (Duke)

Over 8.5

-116

Under 8.5

-111

Cameron Boozer (Duke)

Over 5.5

+136

Under 5.5

-179

Cameron Boozer (Duke)

Over 10.5

-115

Under 10.5

-112

Dame Sarr (Duke)

Over 4.5

-128

Under 4.5

-101

Latest regular season and playoff games stats.

Siena Stats

Duke Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games

Moneyline

• 10 wins and 0 defeats in the last 10 games

Point Spread

• +27.5 Betting Line: Have covered the spread in the last 10 games

Point Spread

• -27.5 Betting Line: Have covered the spread in 3 of the last 10 games

Total Points

• Game Totals: An average of 133.00 pts in the previous 10 games
• Over 135.5: Covered in 4 of the previous 10 games
• Team Totals: Have scored an average of 67.50 pts and allowed 65.50 pts in the last 10 games

Total Points

• Game Totals: An average of 143.20 pts in the previous 10 games
• Over 135.5: Covered in 6 of the previous 10 games
• Team Totals: Have scored an average of 80.90 pts and allowed 62.30 pts in the last 10 games

NCAAB Regular Season Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	32-2	2798	2147	651	21-0	11-2	11W
Virginia	29-5	2742	2326	416	19-1	10-4	1L
Miami	25-8	2704	2349	355	16-4	9-4	1L
North Carolina	24-8	2553	2282	271	19-1	5-7	2L
Clemson	24-10	2521	2269	252	16-3	8-7	1L
Louisville	23-10	2797	2382	415	16-2	7-8	1L
California	21-11	2492	2344	148	17-4	4-7	2L
Stanford	20-12	2431	2326	105	12-7	8-5	1L
NC State	20-13	2762	2525	237	13-7	7-6	1L
SMU	20-13	2779	2561	218	17-3	3-10	1L
Virginia Tech	19-13	2521	2396	125	15-4	4-9	2L
Florida State	18-15	2652	2572	80	12-8	6-7	1L
Wake Forest	17-16	2602	2543	59	12-6	5-10	1L
Syracuse	15-17	2400	2376	24	12-6	3-11	6L
Notre Dame	13-18	2308	2335	-27	11-7	2-11	2L
Pittsburgh	13-20	2327	2370	-43	8-10	5-10	1L
Boston College	11-20	2090	2191	-101	10-10	1-10	1W
Georgia Tech	11-20	2287	2400	-113	10-10	1-10	12L

Metro Atlantic Athletic	Overall	PF	PA	N. Pts	Home	Away	Strk
Merrimack	23-11	2330	2260	70	13-2	10-9	1L
Siena	23-11	2398	2233	165	11-4	12-7	4W
Fairfield	21-13	2528	2432	96	13-4	8-9	1L
Marist	19-12	2160	1979	181	11-4	8-8	1L
Quinnipiac	19-13	2411	2303	108	10-6	9-7	1L
Saint Peter's	17-12	2054	1984	70	13-2	4-10	1L
Iona	18-14	2363	2340	23	11-5	7-9	1L
Mount St. Mary's	15-17	2178	2244	-66	8-5	7-12	1L
Sacred Heart	14-19	2482	2528	-46	8-5	6-14	1L
Manhattan	12-20	2369	2526	-157	8-7	4-13	4L
Canisius	10-21	1951	2184	-233	7-8	3-13	1L
Niagara	8-22	1916	2137	-221	6-7	2-15	1L
Rider	4-25	1840	2204	-364	4-9	0-16	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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