South Florida vs Louisville Prediction, Picks & Odds | 19 Mar 2026

College Basketball Betting Preview: South Florida vs Louisville

No. 11 South Florida Bulls square off against No. 6 Louisville Cardinals in this NCAA Tournament First Round matchup at KeyBank Center in Buffalo, with tip-off scheduled for 12:30 on Thursday, March 19.

We’re confident about the number of points to be scored when South Florida and Louisville take to the court. Therefore, the prediction is Under 163.5 points which is available at -105.

The South Florida Bulls (25-8, 1st in the American) are coming off a 70-55 home victory against the Wichita State Shockers.

The Louisville Cardinals (23-10, 6th in the ACC) lost their last game, falling 78-73 on the road to the Miami Hurricanes.

NCAAB Regular Season	Overall	PF	PA	N. Pts	Home	Away	Strk
Louisville	0-0	0	0	0	0-0	0-0	-
South Florida	0-0	0	0	0	0-0	0-0	-

View Full Standings

South Florida vs Louisville Prediction & Picks

Explore our top South Florida vs Louisville betting tips, including a match prediction, correct score forecast, player performance props and a bet builder ready to use.

Game Prediction

We’re going for a modest total for this upcoming college contest. Under 163.5 points could be on the money and our pick is currently available at -105.

Our expert basketball picks always start with checking the latest team news and understanding how it might impact the matchup. From there, we dive into the most valuable college hoops stats to uncover the insights that matter most.

Key South Florida vs Louisville stats:

• The 163.5 line hasn’t been covered in 8 of the last 10 USF games.
• The 163.5 line hasn’t been covered in 4 of the last 5 USF games.
• The 163.5 line hasn’t been covered in the last 3 USF games.
• The 163.5 line hasn’t been covered in 16 of the last 20 Louisville games.
• The 163.5 line hasn’t been covered in 4 of the last 5 Louisville games.
• The 163.5 line hasn’t been covered in the last 2 Louisville games.

Under 163.5 Probability

The latest odds at the best betting apps suggest our pick carries a 51.3% chance of winning. Based on our in-depth research, we calculate the actual probability to be closer to 60%. This college basketball wager can therefore be backed with confidence.

Those looking for larger odds can include an Under selection with other picks when they place a Bet Builder. A bigger potential payout could be on the cards with this bet.

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Our Game Prediction

Under 163.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 18, 17:03). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Joseph Pinion Under 2.5 Assists -114

Joseph Pinion (USF) can be backed to have Under 2.5 assists at -114. It might well be the case that he doesn’t cover the line and this Player Assists bet is appealing.

Latest Joseph Pinion Player Prop Odds

Points

Over 13.5

-137

Under 13.5

+106

Assists

Over 2.5

-114

Under 2.5

-114

Rebounds

Over 4.5

+115

Under 4.5

-149

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J'Vonne Hadley Under 15.5 Points -122

J'Vonne Hadley (Louisville) can be backed to score Under 15.5 points at -122. We are keen to take the selection that he fails to cover this total when it comes to Player Points.

Latest J'Vonne Hadley Player Prop Odds

Points

Over 15.5

-106

Under 15.5

-122

Rebounds

Over 5.5

-114

Under 5.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

South Florida 78 - 79 Louisville

Don’t pass up the opportunity to have a speculative wager on the Cards to achieve a 79-78 victory. We don’t think that there will be too much between the teams.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

South Florida vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Louisville have the shortest price to win this NCAA Tournament game, with the sportsbooks giving the Cards a 63% probability due to their -169 Moneyline betting odds. At +140, South Florida are regarded as having a lower probability of winning.

The current spread is 3.5 and the total points line is 160.5. A Total wager relates to the number of points that will be scored overall. If you’re going for Under 160.5, this outcome can be backed at -110.

Consider every angle when placing your college hoops bets. The top basketball betting sites offer a huge selection of game lines and team props, and it’s all about finding a wager that fits your prediction of the game.

Moneyline

USF

+140

Louisville

-169

Point Spread

USF +3.5

-106

Louisville -3.5

-114

Total Points

Under 160.5

-110

Over 160.5

-110

Ryan Conwell is the favorite to score most points. Odds of -103 can be found for him scoring Over 22.5 points and there is -125 for him to go Under.

Ryan Conwell (Louisville)

Over 22.5

-103

Under 22.5

-125

Wes Enis (USF)

Over 18.5

-103

Under 18.5

-125

J'Vonne Hadley (Louisville)

Over 15.5

-106

Under 15.5

-122

Izaiyah Nelson (USF)

Over 14.5

-122

Under 14.5

-106

Joseph Pinion (USF)

Over 13.5

-137

Under 13.5

+106

Adrian Wooley (Louisville)

Over 13.5

-108

Under 13.5

-120

Isaac McKneely (Louisville)

Over 12.5

-119

Under 12.5

-109

CJ Brown (USF)

Over 9.5

-105

Under 9.5

-123

Josh Omojafo (USF)

Over 9.5

-105

Under 9.5

-123

CJ Brown (USF)

Over 3.5

-130

Under 3.5

-100

Ryan Conwell (Louisville)

Over 2.5

-149

Under 2.5

+115

Wes Enis (USF)

Over 2.5

-103

Under 2.5

-125

Joseph Pinion (USF)

Over 2.5

-114

Under 2.5

-114

Adrian Wooley (Louisville)

Over 2.5

-149

Under 2.5

+115

Izaiyah Nelson (USF)

Over 8.5

-103

Under 8.5

-125

Josh Omojafo (USF)

Over 6.5

+103

Under 6.5

-133

J'Vonne Hadley (Louisville)

Over 5.5

-114

Under 5.5

-114

Adrian Wooley (Louisville)

Over 5.5

-100

Under 5.5

-130

Ryan Conwell (Louisville)

Over 4.5

-130

Under 4.5

-100

Joseph Pinion (USF)

Over 4.5

+115

Under 4.5

-149

Wes Enis (USF)

Over 3.5

-143

Under 3.5

+110

Isaac McKneely (Louisville)

Over 3.5

-114

Under 3.5

-114

CJ Brown (USF)

Over 3.5

+105

Under 3.5

-135

It’s good to consider all wagering options when it comes to college basketball and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether the next shot will be a Two or a Three-pointer.

Latest regular season and playoff games stats.

South Florida Stats

Louisville Stats

Moneyline

• 10 wins and 0 defeats in the last 10 games

Moneyline

• 6 wins and 4 defeats in the last 10 games

Point Spread

• +4.5 Betting Line: Have covered the spread in the last 10 games

Point Spread

• -4.5 Betting Line: Have covered the spread in 4 of the last 10 games

Total Points

• Game Totals: An average of 148.10 pts in the previous 10 games
• Over 163.5: Covered in 2 of the previous 10 games
• Team Totals: Have scored an average of 81.60 pts and allowed 66.50 pts in the last 10 games

Total Points

• Game Totals: An average of 158.20 pts in the previous 10 games
• Over 163.5: Covered in 3 of the previous 10 games
• Team Totals: Have scored an average of 82.50 pts and allowed 75.70 pts in the last 10 games

NCAAB Regular Season Table Select Season 2026/20272025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Boston College	0-0	0	0	0	0-0	0-0	-
North Carolina	0-0	0	0	0	0-0	0-0	-
Virginia Tech	0-0	0	0	0	0-0	0-0	-
Virginia	0-0	0	0	0	0-0	0-0	-
Syracuse	0-0	0	0	0	0-0	0-0	-
SMU	0-0	0	0	0	0-0	0-0	-
Pittsburgh	0-0	0	0	0	0-0	0-0	-
Notre Dame	0-0	0	0	0	0-0	0-0	-
NC State	0-0	0	0	0	0-0	0-0	-
California	0-0	0	0	0	0-0	0-0	-
Miami	0-0	0	0	0	0-0	0-0	-
Louisville	0-0	0	0	0	0-0	0-0	-
Georgia Tech	0-0	0	0	0	0-0	0-0	-
Florida State	0-0	0	0	0	0-0	0-0	-
Duke	0-0	0	0	0	0-0	0-0	-
Clemson	0-0	0	0	0	0-0	0-0	-
Wake Forest	0-0	0	0	0	0-0	0-0	-

American Athletic Conference	Overall	PF	PA	N. Pts	Home	Away	Strk
Charlotte	0-0	0	0	0	0-0	0-0	-
East Carolina	0-0	0	0	0	0-0	0-0	-
Memphis	0-0	0	0	0	0-0	0-0	-
North Texas	0-0	0	0	0	0-0	0-0	-
Rice	0-0	0	0	0	0-0	0-0	-
South Florida	0-0	0	0	0	0-0	0-0	-
Temple	0-0	0	0	0	0-0	0-0	-
UTSA	0-0	0	0	0	0-0	0-0	-
Tulane	0-0	0	0	0	0-0	0-0	-
Tulsa	0-0	0	0	0	0-0	0-0	-
UAB	0-0	0	0	0	0-0	0-0	-
Wichita State	0-0	0	0	0	0-0	0-0	-

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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