Southern Indiana vs Butler Prediction, Picks & Odds | 05 Nov 2025

College Basketball Betting Preview: Southern Indiana vs Butler

The Southern Indiana Screaming Eagles face the Butler Bulldogs, with tip-off scheduled for 19:00 on Wednesday, November 5. Our betting preview features expert NCAAB predictions, betting tips, the latest odds and H2H stats.

There’s a lot to like about Southern Indiana +20.5 when they meet Butler. You can get odds of -110 and we need the underdogs to avoid a sizeable defeat.

Southern Indiana Screaming Eagles were defeated in their previous game. On the road, they suffered a 74-69 reverse against Tennessee State Tigers.

Butler Bulldogs were beaten in their last game, losing 100-93 to Boise State Broncos.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Butler	16-16	2540	2481	59	13-8	3-8	1L
Southern Indiana	7-23	2062	2212	-150	3-10	4-13	2L

View Full Standings

Southern Indiana vs Butler Prediction & Picks

Head into Southern Indiana vs Butler with expert betting insights, including our main match prediction, best correct score pick and a value-driven bet builder. Dive into each section below for more.

Game Prediction

We like the look of the underdogs +20.5 at odds of -110. We think Southern Indiana can take on the big favorites and put up a strong showing in this college matchup.

The college basketball handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Southern Indiana vs Butler stats:

• The +20.5 line has been covered by USI in 5 consecutive games.
• The +20.5 line has been covered by USI in 19 of their last 20 games on the road.
• The +20.5 line has been covered by USI in 9 of their last 10 games.
• The -20.5 line hasn’t been covered by Butler in 15 consecutive games at home.
• The -20.5 line hasn’t been covered by Butler in 19 of their last 20 games.

Southern Indiana +20.5 Probability

The best betting sites suggest there’s a 52.4% chance of our pick delivering a return. However, our research has found that the actual probability is closer to 60%. It’s why we think it’s worth placing this college basketball bet.

As a betting alternative, you can choose to buy or sell points when it comes to your spread pick. Buy if you want a safer wager and sell to get more juice from the line.

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Our Game Prediction

Southern Indiana +20.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Nov 4, 23:06). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Southern Indiana 67 - 83 Butler

Should you wish to go for a speculative bet, try the Bulldogs to win 83-67 on the correct score lines. This should be a fun wager which could potentially yield a huge return.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Southern Indiana vs Butler Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You might not get rich backing Butler at -10000. However, the sportsbooks’ betting odds imply a 99% chance of winning this college game. At +2000, Southern Indiana are regarded as having a lower probability of winning.

The current spread is 22.5 and total points is 155.5. There is no denying the popularity of betting on the Totals. Those that want to back Under 155.5 can find odds of -105 available.

The good news is that you can access a wide range of team props and game lines for most college basketball contests. The best betting apps have a huge range of pre-game and in-game wagering options.

Moneyline

USI

+2000

Butler

-10000

Point Spread

USI +22.5

-110

Butler -22.5

-110

Total Points

Under 155.5

-105

Over 155.5

-115

As an alternative to the game lines and team props, check out the player props that are available. These can be a great alternative if you want to focus on a player’s performance. The best gambling sites will provide lots of options.

Micro betting is an exciting way to wager on college basketball. There are many live lines and it’s a simple case of predicting what is going to happen. Next Field Goal, where you select if the shot will be a two or three-pointer are among the options.

Latest regular season and playoff games stats.

Southern Indiana Stats

Butler Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +20.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +20.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -20.5 Betting Line: Have not covered the spread in any of the last 10 games
• -20.5 Betting Line at Home: Have not covered the spread in any of the last 10 home games

Total Points

• Game Totals: An average of 141.70 pts in the previous 10 games
• Game Totals on the Road: An average of 141.70 pts in the previous 10 games on the road
• Over 155.5: Covered in 1 of the previous 10 games
• Over 155.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 66.80 pts and allowed 74.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 66.50 pts and allowed 75.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 156.30 pts in the previous 10 games
• Game Totals at Home: An average of 158.60 pts in the previous 10 home games
• Over 155.5: Covered in 5 of the previous 10 games
• Over 155.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 75.00 pts and allowed 81.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 79.10 pts and allowed 79.50 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
St. John's	28-6	2773	2379	394	18-3	10-3	6W
Villanova	24-8	2469	2265	204	15-4	9-4	1L
Seton Hall	21-12	2321	2156	165	13-5	8-7	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Georgetown	16-18	2503	2479	24	10-8	6-10	1L
Creighton	15-17	2404	2401	3	11-6	4-11	1L
Providence	15-18	2815	2772	43	10-7	5-11	1L
Xavier	15-18	2586	2661	-75	13-7	2-11	1L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

Ohio Valley	Overall	PF	PA	N. Pts	Home	Away	Strk
Tennessee State	23-9	2577	2347	230	13-2	10-7	6W
UT Martin	22-11	2305	2086	219	13-3	9-8	1L
Morehead State	20-13	2484	2466	18	12-2	8-11	1L
Southeast Missouri	20-13	2460	2331	129	11-5	9-8	1L
SIU Edwardsville	19-13	2271	2070	201	10-6	9-7	1L
Lindenwood	18-15	2566	2398	168	10-5	8-10	1L
Tennessee Tech	13-18	2272	2308	-36	8-6	5-12	2L
Eastern Illinois	13-20	2214	2321	-107	9-6	4-14	1L
Little Rock	12-20	2257	2372	-115	7-6	5-14	1L
Southern Indiana	7-23	2062	2212	-150	3-10	4-13	2L
Western Illinois	4-26	1933	2334	-401	3-11	1-15	5L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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