UConn vs DePaul Prediction, Picks & Odds | 21 Dec 2025

College Basketball Betting Preview: UConn vs DePaul

The UConn Huskies go up against the DePaul Blue Demons, with tip-off scheduled for 16:30 on Sunday, December 21.

The total line looks to be on the low side at 137.5. There’s a strong chance that UConn and DePaul will conspire to go above the line and we’re backing Over at -110.

UConn Huskies won their previous game which was at home. It was a 79-60 triumph against Butler Bulldogs.

DePaul Blue Demons were defeated in their last game. On the road, they suffered a 79-66 reverse against St. John's Red Storm.

Head-to-Head Statistics

The scoreline was 72-61 in favor of UConn when they last played DePaul. We’ve seen a UConn win for each of the past 10 games between the teams.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L

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UConn vs DePaul Prediction & Picks

We cover the essential UConn vs DePaul betting angles, featuring our main match prediction, correct score guidance and a carefully crafted bet builder.

Game Prediction

The total line of 137.5 points looks pretty low and we can take advantage by backing the Overs at -110. We can see these college competitors combining to go bigger.

Injuries can influence the outcome and our college basketball handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key UConn vs DePaul stats:

• The 137.5 line has been covered in 11 of the last 18 UConn games on the road.
• The 137.5 line has been covered in 6 of the last 10 UConn games.
• The 137.5 line has been covered in 16 of the last 20 DePaul games.
• The 137.5 line has been covered in 4 of the last 5 DePaul games.
• The 137.5 line has been covered in the last 3 DePaul games at home.

Over 137.5 Probability

According to the top betting apps, there’s a 52.4% likelihood of our pick delivering a return. After careful examination, our analysts calculate this probability to be closer to 60%. This is why we regard this as a value wager.

If you want to get bigger odds on your Over bet, there’s a smart way of doing this. The leading sportsbooks will allow you to move the line on the Totals.

Boost your wager with the newest free bets, sign-up promotions and the best betting offers featured in our easy-to-use guide.

Our Game Prediction

Over 137.5 Points @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Dec 21, 10:56). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

UConn 77 - 66 DePaul

There’s the chance to back the Huskies in lots of different ways and this includes predicting the correct winning score. We’ll go for a 77-66 victory in their favor.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

UConn vs DePaul Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You might not get rich backing UConn at -1000. However, the sportsbooks’ betting odds imply a 91% chance of winning this college game. If you’re looking for an alternative angle, DePaul are trading at +640.

The spread is calculated to be 12.5, while total points comes in at 134.5. There is no denying the popularity of betting on the Totals. There’s an opportunity to bet Over 134.5 at -110.

If you’re betting on college basketball, we recommend heading to the top betting sites and scanning through the wide range of team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

UConn

-1000

DePaul

+640

Point Spread

UConn -12.5

-110

DePaul +12.5

-110

Total Points

Under 134.5

-110

Over 134.5

-110

The gambling sites also allow you to place player prop bets such as Points, Assists, Steals and Rebounds. This means you can focus on an individual player’s performance rather than wager on the actual outcome of the game in question.

There are some exciting college basketball micro betting lines that are created and they are available in-game. Among them are Next Field Goal, where you select if the shot will be a two or three-pointer. The long-ball option pays better, and in today’s game, you can never discount the three-pointer.

Latest regular season and playoff games stats.

UConn Stats

DePaul Stats

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• -14.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -14.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

• +14.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +14.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 139.70 pts in the previous 10 games
• Game Totals on the Road: An average of 142.80 pts in the previous 10 games on the road
• Over 137.5: Covered in 6 of the previous 10 games
• Over 137.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 75.90 pts and allowed 63.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 72.30 pts and allowed 70.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 145.20 pts in the previous 10 games
• Game Totals at Home: An average of 147.80 pts in the previous 10 home games
• Over 137.5: Covered in 7 of the previous 10 games
• Over 137.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 75.30 pts and allowed 69.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 79.00 pts and allowed 68.80 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
St. John's	28-6	2773	2379	394	18-3	10-3	6W
Villanova	24-8	2469	2265	204	15-4	9-4	1L
Seton Hall	21-12	2321	2156	165	13-5	8-7	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Georgetown	16-18	2503	2479	24	10-8	6-10	1L
Creighton	15-17	2404	2401	3	11-6	4-11	1L
Providence	15-18	2815	2772	43	10-7	5-11	1L
Xavier	15-18	2586	2661	-75	13-7	2-11	1L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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