Virginia vs Louisville Prediction, Picks & Odds | 13 Jan 2026

College Basketball Betting Preview: Virginia vs Louisville

The Virginia Cavaliers go up against the Louisville Cardinals, with tip-off scheduled for 19:00 on Tuesday, January 13.

There’s a strong case for backing Louisville on the spread when they face Virginia. The line looks really appealing considering you can get -110 when it comes to the favorites at -3.5.

Virginia Cavaliers won their previous game, beating Stanford Cardinal at home. It was a 70-55 win.

Louisville Cardinals were winners last time out. It was a 75-62 home victory against Boston College Eagles.

Head-to-Head Statistics

Louisville have beaten Virginia in their most recent meetings. On the road, a 70-50 scoreline was enjoyed before a home win by 81-67. The previous 10 games featuring these teams have resulted in eight Virginia victories.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Virginia	29-5	2742	2326	416	19-1	10-4	1L
Louisville	23-10	2797	2382	415	16-2	7-8	1L

View Full Standings

Virginia vs Louisville Prediction & Picks

This Virginia vs Louisville betting guide features sharp analysis across major markets, including a match prediction, correct score bet, valuable player prop picks and a strategic bet builder.

Game Prediction

We are predicting that Louisville will cover the spread in this college contest. -3.5 seems a more than generous line and you can get -110 that the favorites will win by a bigger margin.

The college hoops handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any basketball picks. From there, we interpret the story the stats are telling to help shape our predictions.

Key Virginia vs Louisville stats:

• The -3.5 line has been covered by Louisville in 9 of their last 10 games at home.
• The -3.5 line has been covered by Louisville in 16 of their last 20 games at home.
• The +3.5 line hasn’t been covered by Virginia in 11 of their last 19 games on the road.
• The -3.5 line has been covered by Louisville in 2 consecutive games against Virginia.

Louisville -3.5 Probability

The top betting sites are estimating that there is a 52.4% likelihood of this pick winning. After careful examination, our analysts calculate this probability to be closer to 60%. This is why we regard this as a value bet.

If you’re hunting for bigger odds and feel confident your selection is going to perform well, then consider moving the line and land a bigger potential return.

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Our Game Prediction

Louisville -3.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Jan 12, 23:56). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Isaac McKneely Over 2.5 Rebounds -149

Isaac McKneely (Louisville) can be backed to record Over 2.5 rebounds at -149. We recommend taking the pick that he is able to cover the line, with this Player Rebounds bet hopefully providing a return.

Latest Isaac McKneely Player Prop Odds

Points

Over 11.5

-120

Under 11.5

-108

Assists

Over 1.5

+120

Under 1.5

-156

Rebounds

Over 2.5

-169

Under 2.5

+129

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Ryan Conwell Over 21.5 Points -105

Ryan Conwell (Louisville) can be backed to score Over 21.5 points at -105. There’s a fairly strong case that he will be able to cover the line and we’ll wager on his Player Points.

Latest Ryan Conwell Player Prop Odds

Points

Over 20.5

-132

Under 20.5

+102

Assists

Over 2.5

+126

Under 2.5

-164

Rebounds

Over 5.5

+115

Under 5.5

-149

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Virginia 75 - 82 Louisville

There are lots of different betting angles including the chance to back Louisville on the correct score lines. For example, a 82-75 victory in their favor is available at massive odds.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Virginia vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have Louisville at -208 when it comes to the Moneyline betting, implying the favorites are 68% likely to win this game according to the latest odds. For those wanting to back Virginia, you will find +172 about the underdogs.

The current spread is 4.5 and the total points line is 153.5. A Total bet is always available and can often provide value selections. If you want to back Over 153.5, it’s -108.

College basketball bettors are spoilt for choice thanks to the huge selection of game lines and team props which are available for most matchups on the coupon. Head to the top betting apps and find the best value picks.

Moneyline

Virginia

+172

Louisville

-208

Point Spread

Virginia +4.5

-112

Louisville -4.5

-108

Total Points

Under 153.5

-112

Over 153.5

-108

Ryan Conwell is the favorite to hit the most buckets. You can back -132 that he gets Over 20.5 points. Alternatively, Under is trading at +102.

Ryan Conwell (Louisville)

Over 20.5

-132

Under 20.5

+102

Thijs De Ridder (Virginia)

Over 15.5

-106

Under 15.5

-122

Malik Thomas (Virginia)

Over 13.5

-114

Under 13.5

-114

Adrian Wooley (Louisville)

Over 12.5

-114

Under 12.5

-114

Isaac McKneely (Louisville)

Over 11.5

-120

Under 11.5

-108

Sananda Fru (Louisville)

Over 11.5

-100

Under 11.5

-130

J'Vonne Hadley (Louisville)

Over 10.5

-116

Under 10.5

-111

Sam Lewis (Virginia)

Over 9.5

-169

Under 9.5

+129

Chance Mallory (Virginia)

Over 9.5

-123

Under 9.5

-104

Ryan Conwell (Louisville)

Over 2.5

+126

Under 2.5

-164

Malik Thomas (Virginia)

Over 1.5

+110

Under 1.5

-143

Isaac McKneely (Louisville)

Over 1.5

+120

Under 1.5

-156

Sananda Fru (Louisville)

Over 1.5

+120

Under 1.5

-156

Sananda Fru (Louisville)

Over 7.5

-133

Under 7.5

+103

Thijs De Ridder (Virginia)

Over 6.5

+126

Under 6.5

-164

Ryan Conwell (Louisville)

Over 5.5

+115

Under 5.5

-149

Malik Thomas (Virginia)

Over 4.5

+128

Under 4.5

-167

Isaac McKneely (Louisville)

Over 2.5

-169

Under 2.5

+129

You don’t have to wait for the final outcome when it comes to college basketball micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Latest regular season and playoff games stats.

Virginia Stats

Louisville Stats

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 150.70 pts in the previous 10 games
• Game Totals on the Road: An average of 151.60 pts in the previous 10 games on the road
• Over 153.5: Covered in 4 of the previous 10 games
• Over 153.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 84.20 pts and allowed 66.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 75.70 pts and allowed 75.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 156.00 pts in the previous 10 games
• Game Totals at Home: An average of 159.40 pts in the previous 10 home games
• Over 153.5: Covered in 6 of the previous 10 games
• Over 153.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 84.00 pts and allowed 72.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 94.40 pts and allowed 65.00 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	32-2	2798	2147	651	21-0	11-2	11W
Virginia	29-5	2742	2326	416	19-1	10-4	1L
Miami	25-8	2704	2349	355	16-4	9-4	1L
North Carolina	24-8	2553	2282	271	19-1	5-7	2L
Clemson	24-10	2521	2269	252	16-3	8-7	1L
Louisville	23-10	2797	2382	415	16-2	7-8	1L
California	21-11	2492	2344	148	17-4	4-7	2L
Stanford	20-12	2431	2326	105	12-7	8-5	1L
NC State	20-13	2762	2525	237	13-7	7-6	1L
SMU	20-13	2779	2561	218	17-3	3-10	1L
Virginia Tech	19-13	2521	2396	125	15-4	4-9	2L
Florida State	18-15	2652	2572	80	12-8	6-7	1L
Wake Forest	17-16	2602	2543	59	12-6	5-10	1L
Syracuse	15-17	2400	2376	24	12-6	3-11	6L
Notre Dame	13-18	2308	2335	-27	11-7	2-11	2L
Pittsburgh	13-20	2327	2370	-43	8-10	5-10	1L
Boston College	11-20	2090	2191	-101	10-10	1-10	1W
Georgia Tech	11-20	2287	2400	-113	10-10	1-10	12L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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