Santos Laguna vs Puebla Prediction, Betting Tips, Lineups & Odds | 22 Mar 2026

Liga MX Betting Preview: Santos Laguna vs Puebla

Santos Laguna go head-to-head with Puebla at Estadio Nuevo Corona, with kick-off set for 19:00 on Sunday 22 March.

The way forward could be to back Santos Laguna with a +0.25 Asian Handicap at -139 against Puebla. This means our stake is split between 0 and +0.5, which allows us to land a return with a draw.

Santos Laguna have lost back-to-back Liga MX games at home. In their last league clash, it was a 3-0 away defeat against Guadalajara at Estadio Akron. The Comarca Lagunera team recorded one shot on target and had 44% possession.

Club Puebla hosted Club Necaxa at Estadio Cuahutehmoc in their previous game, ending in a 0-0 draw. La Franja had the lion’s share of the ball boasting 56% possession and three shots on goal.

Head-to-Head Statistics

Puebla have three successive wins against Santos. In the last clash, home side Puebla claimed a 1-0 victory at Estadio Cuahutehmoc. The past 10 H2H meetings have featured five Puebla victories, two draws and three Santos wins.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
12	Puebla	11	3	3	5	9	13	-4	9:13	12
18	Santos Laguna	11	1	2	8	12	29	-17	12:29	5

View Full Table

Santos have 1 win, 7 losses and 2 draws, averaging 1.1 goals from 3.7 shots on goal and 7.8 attempts. Los Guerreros have averaged 44.3% possession and 4.0 corners per game, with their opponents scoring 2.6 goals from 6.1 shots on goal, 12.5 attempts and 3.9 corners.

Top goalscorer is Ezequiel Bullaude on 4 goals, while Lucas Di Yorio has bagged 3 and Fran Villalba 2. Lucas Di Yorio and Ramiro Sordo have been top assistors with 2.

Club Puebla have 3 victories, 4 defeats and 3 draws, with an average of 0.9 goals from 4.6 shots on goal and 10.2 attempts. There’s been an average of 44.0% possession, 4.4 corners taken and 5.7 corners against, while they’ve conceded 1.2 goals from 4.5 shots on goal and 10.8 attempts.

Edgar Guerra got 3 goals, Esteban Lozano notched 2, while Jose Pachuca and two other players scored 1. Carlos Baltazar and Kevin Velasco have clocked up 2 assists each in the last 10 games.

Predicted & Confirmed Lineups

Santos Laguna predicted lineup (4-2-3-1): Carlos Acevedo Lopez (GK), José Javier Abella, Óscar Haret Ortega, Bruno Amione, Emmanuel Echeverria, Carlos Gruezo, Javier Güemez, Fran Villalba, Ezequiel Bullaude, Luis Gómez, Lucas Di Yorio.

Puebla predicted lineup (5-3-2): Ricardo Daniel Gutiérrez (GK), Iker Moreno, Juan Pablo Vargas, Eduardo Navarro, Jose Pachuca, Nicolás Díaz, Kevin Velasco, Luis Gabriel Rey, Alonso Ramírez, Emiliano Gómez, Edgar Guerra.

Santos Laguna vs Puebla Prediction & Betting Tips

Get the full betting picture for Santos Laguna vs Puebla, including our expert match prediction, likely scoreline, key corners pick, must-watch player props and a tailored bet builder ready to use.

Match Prediction

We’ll split our stake by backing Santos Laguna +0.25 at odds of -139 for this Asian Handicap wager. There’s every chance that we see a strong performance from the home team in this Liga MX encounter.

A good deal of research goes into our football betting tips. We start by studying the latest form and getting a handle on injuries. The key Liga MX stats can then be used as the missing piece of the jigsaw.

Key Santos Laguna vs Puebla league stats:

• The -0.25 line hasn’t been covered by Puebla in 17 of their last 19 games on the road.
• The -0.25 line hasn’t been covered by Puebla in 8 of their last 10 games on the road.
• The -0.25 line hasn’t been covered by Puebla in 2 consecutive games.

When you look at the latest odds, our pick has a 58.1% chance of winning. However, we have this number between 65-70% based on our in-depth research. This is why we regard this as a value wager.

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Our Match Prediction

Santos Asian Hcp +0.25 @ -139 Watch Live Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 21, 01:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santos 2 - 1 Puebla

We’ve got a correct score prediction which involves Santos winning 2-1. Odds of +700 look appealing and we should get a run for our money here.

Player Prop Picks

Top Pick: Ezequiel Bullaude to Score +350

Ezequiel Bullaude (Santos) has racked up three goals in his past five Liga MX matches. When it comes to him finding the net, we believe the +350 available is appealing when backing him on the Anytime Goalscorer market.

Latest Ezequiel Bullaude Player Prop Odds

Goalscorer

Anytime

+350

First

+1000

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Corners Prediction

Puebla To Have Most Corners +108

It’s been an average of 5.90 Puebla corners in the past 10 away matches, while the last 10 Santos games have seen them average 4.00. Puebla can be taken at +108 to be awarded the most corners.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

7.90 4.00 3.90

Home

9.50 4.40 5.10

Away

10.10 4.30 5.80

Puebla

Total

10.10 4.40 5.70

Home

9.50 3.70 5.80

Away

10.50 5.90 4.60

Latest Corner Odds

Total Corners

Over 9.5

-130

Under 9.5

-115

Santos Corners

Over 4.5

-139

Under 4.5

-112

Puebla Corners

Over 4.5

-125

Under 4.5

-125

Most Corners

1

-105

X

+650

2

+108

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santos Laguna vs Puebla Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

If you’re looking to wager Santos Laguna to secure victory in the Liga MX, then the bookmakers have chalked them up at +165. Club Puebla are on offer at betting odds of +138 and the draw is +260.

It sometimes pays to take the Draw No Bet option meaning there’s a safety net if the game ends all square. Puebla can be backed at -137 or alternatively Santos are on offer at -109.

For those expecting a high-scoring contest, Over 2.5 Goals is the shortest price. Punters expecting both teams to find the net can get -208 when it comes to BTTS Yes.

No matter what Liga MX match is taking place, you will find hundreds of markets being offered. Peruse the various choices that are presented at the leading football betting sites.

Full-Time Result

1

+165

X

+260

2

+138

Half-Time Result

1

+205

X

+132

2

+185

Double Chance

1X

-192

12

-400

X2

-238

Draw No Bet

1

-109

2

-137

Asian Handicap

1 Hcp +0.25

-139

2 Hcp -0.25

+107

Total Goals

Under 2.5

+120

Over 2.5

-167

Both Teams to Score

Yes

-208

No

+135

There is +155 available that Edgar Andres Guerra finds the net anytime, while the favourite to score the first goal is on offer at +430.

Edgar Andres Guerra (Puebla)

First

+155

Anytime

+430

Emiliano Gomez (Puebla)

First

+155

Anytime

+440

Lucas Di Yorio (Santos)

First

+160

Anytime

+460

Ramiro Sordo (Santos)

First

+220

Anytime

+650

Alexis Canelo (Puebla)

First

+270

Anytime

+750

Fran Villalba (Santos)

First

+310

Anytime

+900

Fernando Monárrez (Puebla)

First

+320

Anytime

+950

Iker Moreno (Puebla)

First

+340

Anytime

+950

Ezequiel Bullaude (Santos)

First

+350

Anytime

+1000

Owen Gonzalez (Puebla)

First

+390

Anytime

+1100

Cristian Dájome (Santos)

First

+400

Anytime

+1150

Salvador Mariscal Murra (Santos)

First

+480

Anytime

+1400

Javier Güemez (Santos)

First

+575

Anytime

+1600

Alonso Ramírez (Puebla)

First

+700

Anytime

+2000

Carlos Gruezo (Santos)

First

+750

Anytime

+2200

Kevin Balanta (Santos)

First

+800

Anytime

+2200

Bruno Amione (Santos)

First

+800

Anytime

+2200

Santos Laguna have gone without a win at Estadio Nuevo Corona in the last four games. The Comarca Lagunera team have clocked up five losses, four wins and one draw in the past 10 home games, recording an average of 1.30 goals per match and conceding 1.50.

Puebla have finished with six defeats, two wins and two draws in the past 10 away matches, netting an average of 1.00 goals per game and conceding 1.50.

The last Estadio Nuevo Corona meeting saw Puebla beat Santos 2-0. Santos have landed four victories, Puebla have one win and there’s been two draws in the past 7 H2H matches at Estadio Nuevo Corona.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Santos Laguna Home Stats		4-1-5	2.80	1.30	1.50	6	4	6	4
Puebla Away Stats		2-2-6	2.50	1.00	1.50	5	5	5	5

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Santos Laguna vs Puebla Lineups & Team News

Stay informed and review the Santos vs Puebla team news before placing your bets. We’ll share both predicted and confirmed lineups for the Liga MX along with the latest injury news.

Santos Laguna Team Page Puebla Team Page

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