Duke vs Louisville Prediction, Picks & Odds | 06 Jan 2026

College Basketball Betting Preview: Duke vs Louisville

The Duke Blue Devils go up against the Louisville Cardinals, with tip-off scheduled for 19:00 on Tuesday, January 6.

There’s an appealing -102 that Louisville are able to get the better of Duke. This wager can be secured on the Moneyline and we’re confident that it can happen.

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Duke Blue Devils triumphed in their previous game. It was on the road where Florida State Seminoles were beaten 91-87.

Louisville Cardinals were beaten last game and this was on the road. Stanford Cardinal claimed a 80-76 win.

Head-to-Head Statistics

Duke won the most recent matchup between these teams. A 73-62 victory was registered against Louisville. It’s been six wins on the bounce for Duke when playing Louisville. On the head-to-head front, they have won 7 of the past 10.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	14-1	1306	990	316	9-0	5-1	3W
Louisville	11-4	1338	1052	286	8-1	3-3	2L

View Full Standings

Duke vs Louisville Prediction & Picks

Step into Duke vs Louisville with confidence, armed with our expert match prediction, likely scoreline, key player prop plays and a custom-built bet builder for maximum value.

Game Prediction

Louisville are on offer at generous -102 when it comes to winning this college contest. Our pick is that they’ll outscore the road team and there’s value available when it comes to these betting odds.

Knowing which players are injured gives us a valuable edge when making basketball predictions. After reviewing the form guide, we turn to the latest stats to shape our college hoops picks.

Key Duke vs Louisville stats:

• Louisville have won 8 consecutive games at home.
• Louisville have won 19 of their last 20 games at home.
• Louisville have won 9 of their last 10 games at home.

Louisville Moneyline Probability

The best betting apps make it a 50.5% chance that our pick is settled as a winner. However, our analysts think that the probability is close to 60% taking all factors into consideration. That means we’re regarding it as a value wager.

It’s worth considering all the options. If you’re looking for tastier odds about Louisville to triumph and a certain number of points to be scored, then the Match Result & Total lines could be a good way forward.

Elevate your wagering experience with the latest free bets, promos and top betting offers listed in our comprehensive bonus guide.

Our Game Prediction

Louisville Moneyline @ -102 Bet Now

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Player Prop Picks

Top Pick: Ryan Conwell Over 4.5 Rebounds -118

Ryan Conwell (Louisville) can be backed to secure Over 4.5 rebounds at -118. We think it’s achievable that he will cover the Player Rebounds line based on the information to hand.

Latest Ryan Conwell Player Prop Odds

Points

Over 20.5

-130

Under 20.5

-100

Rebounds

Over 4.5

-119

Under 4.5

-109

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Isaac McKneely Under 11.5 Points -105

Isaac McKneely (Louisville) can be wagered to total Under 11.5 points at -105. It’s anticipated that he might fall short of the mark and that leads us to an Unders bet.

Correct Score Prediction

Duke 76 - 81 Louisville

For those wanting a big return from a small stake, consider the correct score lines. For example, Louisville can be backed to win 81-76 at huge betting odds.

Duke vs Louisville Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

You can choose Louisville at -102 or alternatively Duke who have betting odds of -118. From a percentage point-of-view, the leading sportsbooks give the visiting team a 54% chance of success.

The spread is currently 1.5, with the total points line at 161.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. If you’re going for Under 161.5, this outcome can be backed at -110.

The good news is that you’ll find a strong selection of game lines and team props for most college contests. The best basketball betting sites provide a wide range of pre-game and in-game wagering options.

Moneyline

Duke

-118

Louisville

-102

Point Spread

Duke -1.5

-100

Louisville +1.5

-122

Total Points

Under 161.5

-110

Over 161.5

-110

In terms of landing the most baskets, favorite Cameron Boozer is available at -105 to rack up Over 24.5 points. If you want to go Under, then -123 is available.

Cameron Boozer (Duke)

Over 24.5

-105

Under 24.5

-123

Ryan Conwell (Louisville)

Over 20.5

-130

Under 20.5

-100

Isaiah Evans (Duke)

Over 13.5

-110

Under 13.5

-118

Isaac McKneely (Louisville)

Over 11.5

-127

Under 11.5

-102

J'Vonne Hadley (Louisville)

Over 11.5

-115

Under 11.5

-112

Patrick Ngongba II (Duke)

Over 10.5

-106

Under 10.5

-122

Sananda Fru (Louisville)

Over 10.5

+110

Under 10.5

-143

Caleb Foster (Duke)

Over 9.5

-114

Under 9.5

-114

Cameron Boozer (Duke)

Over 3.5

-196

Under 3.5

+148

Cameron Boozer (Duke)

Over 10.5

+109

Under 10.5

-141

Patrick Ngongba II (Duke)

Over 6.5

+115

Under 6.5

-149

J'Vonne Hadley (Louisville)

Over 5.5

+103

Under 5.5

-133

Ryan Conwell (Louisville)

Over 4.5

-119

Under 4.5

-109

There are some exciting college basketball micro betting lines that are created and they are available in-game. Among them are Next Field Goal, where you select if the shot will be a two or three-pointer. The long-ball option pays better, and in today’s game, you can never discount the three-pointer.

Latest regular season and playoff games stats.

Duke Stats

Louisville Stats

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• -1.5 Betting Line: Have covered the spread in 8 of the last 10 games
• -1.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• +1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +1.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 152.00 pts in the previous 10 games
• Game Totals on the Road: An average of 156.60 pts in the previous 10 games on the road
• Over 161.5: Covered in 4 of the previous 10 games
• Over 161.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 83.80 pts and allowed 68.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 87.20 pts and allowed 69.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 153.70 pts in the previous 10 games
• Game Totals at Home: An average of 161.30 pts in the previous 10 home games
• Over 161.5: Covered in 3 of the previous 10 games
• Over 161.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 85.30 pts and allowed 68.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 94.70 pts and allowed 66.60 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	14-1	1306	990	316	9-0	5-1	3W
North Carolina	13-2	1220	989	231	11-0	2-2	1L
California	13-2	1222	1028	194	13-1	0-1	1W
Miami	12-2	1239	949	290	10-1	2-1	7W
SMU	12-2	1281	1077	204	11-0	1-2	3W
Virginia	12-2	1207	954	253	9-0	3-2	1W
Clemson	12-3	1173	985	188	9-0	3-3	5W
Virginia Tech	12-3	1253	1110	143	10-0	2-3	1L
Stanford	12-3	1184	1063	121	8-3	4-0	1W
Louisville	11-4	1338	1052	286	8-1	3-3	2L
NC State	11-5	1358	1142	216	9-3	2-2	1W
Syracuse	10-5	1113	979	134	8-2	2-3	1W
Wake Forest	10-5	1229	1114	115	8-2	2-3	1W
Notre Dame	10-5	1115	1001	114	8-1	2-4	1L
Georgia Tech	10-6	1211	1134	77	10-3	0-3	1L
Florida State	7-8	1258	1188	70	7-4	0-4	2L
Pittsburgh	7-8	1099	1030	69	6-4	1-4	2L
Boston College	7-8	1042	1011	31	6-6	1-2	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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