Louisville vs Clemson Prediction, Picks & Odds | 28 Feb 2026

College Basketball Betting Preview: Louisville vs Clemson

The Louisville Cardinals face the Clemson Tigers, with tip-off scheduled for 14:00 on Saturday, February 28.

If you are looking for a value pick, then +104 that Clemson beat Louisville certainly stands out. We’re expecting the home team to win on the Moneyline and there are generous odds available.

Louisville Cardinals were defeated in their previous game. On the road, they suffered a 77-74 reverse against North Carolina Tar Heels.

Clemson Tigers lost their last game, being beaten at home to Florida State Seminoles 70-65.

Head-to-Head Statistics

Louisville have won two on the bounce against Clemson. Both victories came at home by 74-64 and 76-73 scorelines. Louisville have won six of the past 10 games that these teams have played.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Clemson	20-8	2087	1837	250	13-3	7-5	4L
Louisville	20-8	2418	2015	403	14-2	6-6	1L

View Full Standings

Louisville vs Clemson Prediction & Picks

We cover the key Louisville vs Clemson betting angles, showcasing our expert match prediction, correct score selection and a bet builder tailored for the best value.

Game Prediction

It’s time to side with Clemson to record a victory in this college matchup. The home team should have the upper hand and the +104 for our Moneyline pick looks a good price.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant college hoops stats, this gives us a strong foundation for accurate basketball picks.

Key Louisville vs Clemson stats:

• Clemson have won 16 of their last 20 games at home.
• Clemson have won 7 of their last 10 games at home.
• Louisville have lost 3 of their last 5 games on the road.
• Louisville have lost their last 2 games on the road.

Clemson Moneyline Probability

The best betting sites suggest there’s a 49% chance of our pick delivering a return. However, our research has found that the actual probability is between 55-60%. It’s why we think it’s worth placing this college basketball wager.

If you want to back Clemson to triumph at bigger odds, why not consider a bet on the Double Result lines? You simply need them to be leading at half-time and full-time.

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Our Game Prediction

Clemson Moneyline @ +104 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Feb 27, 18:02). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Louisville 75 - 79 Clemson

Don’t pass up the opportunity to have a speculative wager on Clemson to achieve a 79-75 victory. We don’t think that there will be too much between the teams.

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Louisville vs Clemson Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The latest Moneyline odds are +102 that Clemson win, while Louisville have been chalked up at -122. The leading sportsbooks give the hosts a 50% chance of success.

The spread is calculated to be 1.5, while total points comes in at 146.5. A Total wager relates to the number of points that will be scored overall. If you want to back Over 146.5, it’s -115.

College hoops fans are spoilt for choice thanks to the wide range of team props and game lines which are available for every contest on the coupon. Head to the top basketball sportsbooks and find the best value picks.

Moneyline

Louisville

-122

Clemson

+102

Point Spread

Louisville -1.5

-105

Clemson +1.5

-115

Total Points

Under 146.5

-105

Over 146.5

-115

Prop bets don’t involve betting on a team to win and instead might look at a player’s individual performance. For example, the number of Points they might score or the number of Assists they might have.

Micro betting provides a rollercoaster ride for college basketball bettors. It can be great to enjoy the live lines, with the opportunity to bet on the Next Field Goal. Watch the live action before deciding which way to go.

Latest regular season and playoff games stats.

Louisville Stats

Clemson Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -1.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +1.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +1.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 159.80 pts in the previous 10 games
• Game Totals on the Road: An average of 157.20 pts in the previous 10 games on the road
• Over 146.5: Covered in 8 of the previous 10 games
• Over 146.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 83.50 pts and allowed 76.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 79.60 pts and allowed 77.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 136.10 pts in the previous 10 games
• Game Totals at Home: An average of 133.90 pts in the previous 10 home games
• Over 146.5: Covered in 2 of the previous 10 games
• Over 146.5 at Home: Covered in 1 of the previous 10 home games
• Team Totals: Have scored an average of 69.00 pts and allowed 67.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 69.30 pts and allowed 64.60 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	26-2	2325	1761	564	16-0	10-2	5W
Virginia	25-3	2305	1897	408	15-1	10-2	9W
Miami	22-6	2322	1977	345	14-3	8-3	1W
North Carolina	22-6	2257	1981	276	17-0	5-6	2W
Clemson	20-8	2087	1837	250	13-3	7-5	4L
Louisville	20-8	2418	2015	403	14-2	6-6	1L
California	20-8	2198	2032	166	17-3	3-5	3W
NC State	19-9	2352	2082	270	12-5	7-4	1L
SMU	19-9	2413	2167	246	16-2	3-7	1L
Virginia Tech	18-10	2206	2073	133	14-3	4-7	1W
Stanford	17-11	2102	2025	77	11-6	6-5	1W
Syracuse	15-13	2117	2054	63	12-5	3-8	2L
Florida State	14-14	2232	2180	52	10-8	4-6	1L
Wake Forest	14-14	2207	2152	55	10-6	4-8	2L
Notre Dame	12-16	2065	2082	-17	10-6	2-10	2L
Georgia Tech	11-17	2075	2165	-90	10-8	1-9	9L
Pittsburgh	10-18	1958	2009	-51	8-9	2-9	1L
Boston College	10-18	1896	1974	-78	9-10	1-8	1W

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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