Louisville vs Clemson Prediction, Picks & Odds | 28 Feb 2026
College Basketball Betting Preview: Louisville vs Clemson
The Louisville Cardinals face the Clemson Tigers, with tip-off scheduled for 14:00 on Saturday, February 28.
If you are looking for a value pick, then +104 that Clemson beat Louisville certainly stands out. We’re expecting the home team to win on the Moneyline and there are generous odds available.
Louisville Cardinals were defeated in their previous game. On the road, they suffered a 77-74 reverse against North Carolina Tar Heels.
Clemson Tigers lost their last game, being beaten at home to Florida State Seminoles 70-65.
Head-to-Head Statistics
Louisville have won two on the bounce against Clemson. Both victories came at home by 74-64 and 76-73 scorelines. Louisville have won six of the past 10 games that these teams have played.
| NCAAB | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
Clemson
|
24-10 | 2521 | 2269 | 252 | 16-3 | 8-7 | 1L |
Louisville
|
23-10 | 2797 | 2382 | 415 | 16-2 | 7-8 | 1L |
Louisville vs Clemson Prediction & Picks
Explore our best Louisville vs Clemson picks, including our main match prediction, correct score forecast, player performance props and a bet builder ready to use.
Game Prediction
It’s time to side with Clemson to record a victory in this college matchup. The home team should have the upper hand and the +104 for our Moneyline pick looks a good price.
We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant college hoops stats, this gives us a strong foundation for accurate basketball picks.
Key Louisville vs Clemson stats:
Clemson Moneyline Probability
The best betting sites suggest there’s a 49% chance of our pick delivering a return. However, our research has found that the actual probability is between 55-60%. It’s why we think it’s worth placing this college basketball wager.
If you want to back Clemson to triumph at bigger odds, why not consider a bet on the Double Result lines? You simply need them to be leading at half-time and full-time.
Before placing your wager, discover the best bonus deals. Our guide highlights the most rewarding betting offers available.
Player Prop Picks
Cade Tyson (Minnesota) can be backed to secure Over 2.5 assists at +126. We feel pretty confident that he’ll be able to cover the Player Assists total which looks generous.
RJ Godfrey (Clemson) is available at -123 to score Over 11.5 points. We’ve found an opportunity to bet on Player Points where we’re able to back him to cover the line.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Clemson on the moneyline, along with Over 146.5 points and Clemson/BTTS Yes on the Result & Both Teams to Score lines.
We recommend a same game parlay as it’s a fantastic way of wagering on a single event. Many basketball bettors like to create a personalised wager which reflects their predictions for how a game is going to play out.
Correct Score Prediction
75
-
79
Clemson
Don’t pass up the opportunity to have a speculative wager on Clemson to achieve a 79-75 victory. We don’t think that there will be too much between the teams.
Louisville vs Clemson Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The latest Moneyline odds are +110 that Clemson win, while Louisville have been chalked up at -132. The leading sportsbooks give the hosts a 48% chance of success.
The spread is calculated to be 1.5, while total points comes in at 146.5. A Total wager relates to the number of points that will be scored overall. If you want to back Over 146.5, it’s -115.
College hoops fans are spoilt for choice thanks to the wide range of team props and game lines which are available for every contest on the coupon. Head to the top basketball sportsbooks and find the best value picks.
The favorite to hit the most buckets is Mikel Brown Jr.. Odds of -105 can be found for him scoring Over 18.5 points and there is -123 for him to go Under.
Micro betting provides a rollercoaster ride for college basketball bettors. It can be great to enjoy the live lines, with the opportunity to bet on the Next Field Goal. Watch the live action before deciding which way to go.
- NCAAB: 15/03 2025 Clemson 73 Louisville 76
- NCAAB: 08/01 2025 Clemson 64 Louisville 74
- NCAAB: 31/01 2024 Louisville 64 Clemson 70
- NCAAB: 19/02 2023 Clemson 73 Louisville 83
- NCAAB: 12/01 2023 Louisville 70 Clemson 83
- NCAAB: 19/02 2022 Clemson 61 Louisville 70
- NCAAB: 28/01 2021 Louisville 50 Clemson 54
- NCAAB: 15/02 2020 Louisville 62 Clemson 77
- NCAAB: 25/01 2020 Clemson 62 Louisville 80
- NCAAB: 16/02 2019 Clemson 55 Louisville 56
Latest regular season and playoff games stats.
Louisville Stats
Clemson Stats
- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -1.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road
- +1.5 Betting Line: Have covered the spread in 5 of the last 10 games
- +1.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 159.80 pts in the previous 10 games
- Game Totals on the Road: An average of 157.20 pts in the previous 10 games on the road
- Over 146.5: Covered in 8 of the previous 10 games
- Over 146.5 on the Road: Covered in 8 of the previous 10 games on the road
- Team Totals: Have scored an average of 83.50 pts and allowed 76.30 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 79.60 pts and allowed 77.60 pts in the last 10 games on the road
- Game Totals: An average of 136.10 pts in the previous 10 games
- Game Totals at Home: An average of 133.90 pts in the previous 10 home games
- Over 146.5: Covered in 2 of the previous 10 games
- Over 146.5 at Home: Covered in 1 of the previous 10 home games
- Team Totals: Have scored an average of 69.00 pts and allowed 67.10 pts in the last 10 games
- Team Totals at Home: Have scored an average of 69.30 pts and allowed 64.60 pts in the last 10 home games
NCAAB Table Select Season
| Atlantic Coast | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
Duke
|
32-2 | 2798 | 2147 | 651 | 21-0 | 11-2 | 11W |
Virginia
|
29-5 | 2742 | 2326 | 416 | 19-1 | 10-4 | 1L |
Miami
|
25-8 | 2704 | 2349 | 355 | 16-4 | 9-4 | 1L |
North Carolina
|
24-8 | 2553 | 2282 | 271 | 19-1 | 5-7 | 2L |
|
Clemson
|
24-10 | 2521 | 2269 | 252 | 16-3 | 8-7 | 1L |
|
Louisville
|
23-10 | 2797 | 2382 | 415 | 16-2 | 7-8 | 1L |
California
|
21-11 | 2492 | 2344 | 148 | 17-4 | 4-7 | 2L |
Stanford
|
20-12 | 2431 | 2326 | 105 | 12-7 | 8-5 | 1L |
NC State
|
20-13 | 2762 | 2525 | 237 | 13-7 | 7-6 | 1L |
SMU
|
20-13 | 2779 | 2561 | 218 | 17-3 | 3-10 | 1L |
Virginia Tech
|
19-13 | 2521 | 2396 | 125 | 15-4 | 4-9 | 2L |
Florida State
|
18-15 | 2652 | 2572 | 80 | 12-8 | 6-7 | 1L |
Wake Forest
|
17-16 | 2602 | 2543 | 59 | 12-6 | 5-10 | 1L |
Syracuse
|
15-17 | 2400 | 2376 | 24 | 12-6 | 3-11 | 6L |
Notre Dame
|
13-18 | 2308 | 2335 | -27 | 11-7 | 2-11 | 2L |
Pittsburgh
|
13-20 | 2327 | 2370 | -43 | 8-10 | 5-10 | 1L |
Boston College
|
11-20 | 2090 | 2191 | -101 | 10-10 | 1-10 | 1W |
Georgia Tech
|
11-20 | 2287 | 2400 | -113 | 10-10 | 1-10 | 12L |
- Overall = Overall Wins-Losses
- PF = Total Points For
- PA = Total Points Against
- N. Pts = Point Differential
- Home = Home Record
- Away = Away Record
- Strk = Current Streak
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