Loyola Chicago vs San Francisco Prediction, Picks & Odds | 17 Dec 2025

College Basketball Betting Preview: Loyola Chicago vs San Francisco

The Loyola Chicago Ramblers battle the San Francisco Dons, with tip-off scheduled for 22:00 on Wednesday, December 17.

San Francisco can enjoy a huge victory and a wager on the spread could be the best way forward. Back the big favorites off -12.5 to cover the line against Loyola Chicago at -120.

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Loyola Chicago Ramblers were defeated in their previous game. They were beaten at home to Chicago State Cougars by a 84-75 scoreline.

San Francisco Dons lost on the road in their last game. Saint Louis Billikens won 85-75.

Head-to-Head Statistics

It was a 77-76 win for Loyola Chicago when they last played San Francisco. Loyola Chicago have won two of the past 3 games that these teams have played.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
San Francisco	6-5	821	764	57	4-1	2-4	1L
Loyola Chicago	3-8	751	835	-84	3-6	0-2	1L

View Full Standings

Loyola Chicago vs San Francisco Prediction & Picks

Our expert Loyola Chicago vs San Francisco betting tips include a main match prediction, a correct score pick and bet builder advice. Explore each section below for detailed insights.

Game Prediction

We’re confident that San Francisco can enjoy a big win in this college matchup, leading us to go against the spread at -12.5. The line makes lots of appeal and there are odds of -120 that can be taken for the favorites.

Our team of college basketball handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Loyola Chicago vs San Francisco stats:

• The -12.5 line has been covered by San Francisco in 2 of their last 5 games at home.

San Francisco -12.5 Probability

The top betting sites are estimating that there is a 54.6% likelihood of this pick winning. Taking all factors into consideration, our analysts think there’s a stronger chance of success and estimate the probability to be closer to 60%. It’s why we think it’s worth placing this college basketball bet.

The betting sites give you the chance to buy or sell points, meaning that you can select from a variety of lines. Buying means shorter prices, with selling sending the odds upwards.

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Our Game Prediction

San Francisco -12.5 @ -120 Bet Now

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Correct Score Prediction

Loyola Chicago 65 - 82 San Francisco

There’s the chance to back San Francisco in lots of different ways and this includes predicting the correct winning score. We’ll go for a 82-65 victory in their favor.

Loyola Chicago vs San Francisco Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

With an estimated 93% chance of winning, the sportsbooks are taking no chances with their -1250 betting odds about San Francisco triumphing in this college game. If you’re looking for an alternative angle, Loyola Chicago are trading at +720.

The spread is 12.5 and the total points line is currently 142.5. There is no denying the popularity of betting on the Totals. The Over 142.5 selection is available to back at -115.

Whether you’re betting in-game or pre-game, the best betting apps serve up a wide range of game lines and team props to choose from. The options are nearly endless, and it’s awesome to have so much variety.

Moneyline

Loyola Chicago

+720

San Francisco

-1250

Point Spread

Loyola Chicago +12.5

-102

San Francisco -12.5

-120

Total Points

Under 142.5

-105

Over 142.5

-115

The gambling sites also allow you to place player prop bets such as Points, Assists, Steals and Rebounds. This means you can focus on an individual player’s performance rather than wager on the actual outcome of the game in question.

An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Latest regular season and playoff games stats.

Loyola Chicago Stats

San Francisco Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +12.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +12.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -12.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -12.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 140.70 pts in the previous 10 games
• Game Totals on the Road: An average of 145.20 pts in the previous 10 games on the road
• Over 142.5: Covered in 4 of the previous 10 games
• Over 142.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 66.00 pts and allowed 74.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 70.80 pts and allowed 74.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 143.40 pts in the previous 10 games
• Game Totals at Home: An average of 147.80 pts in the previous 10 home games
• Over 142.5: Covered in 6 of the previous 10 games
• Over 142.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 72.30 pts and allowed 71.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 78.70 pts and allowed 69.10 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

West Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Gonzaga	10-1	1011	725	286	7-0	3-1	3W
Saint Mary's	9-2	877	703	174	7-0	2-2	1L
Seattle	8-2	833	653	180	7-2	1-0	3W
Santa Clara	8-3	887	775	112	6-1	2-2	2L
Pacific	8-4	897	795	102	5-0	3-4	1L
Loyola Marymount	7-4	854	746	108	4-4	3-0	3L
Portland	6-4	828	805	23	6-2	0-2	1W
San Francisco	6-5	821	764	57	4-1	2-4	1L
Oregon State	6-5	799	786	13	6-4	0-1	3W
San Diego	4-6	744	758	-14	4-3	0-3	1W
Pepperdine	4-7	806	817	-11	3-4	1-3	1W
Washington State	3-8	828	864	-36	2-4	1-4	5L

Atlantic 10	Overall	PF	PA	N. Pts	Home	Away	Strk
George Mason	10-1	874	714	160	8-0	2-1	1W
Saint Louis	9-1	909	701	208	8-1	1-0	3W
Richmond	9-1	856	711	145	7-0	2-1	4W
St. Bonaventure	10-2	927	825	102	7-0	3-2	1L
Davidson	8-2	764	671	93	6-2	2-0	1W
Dayton	9-3	974	850	124	8-1	1-2	2W
Fordham	8-4	916	750	166	7-2	1-2	2W
George Washington	8-4	1042	907	135	6-2	2-2	2L
Rhode Island	8-4	892	798	94	5-2	3-2	1W
VCU	7-4	921	777	144	6-2	1-2	1W
Saint Joseph's	5-4	689	672	17	5-0	0-4	1L
Duquesne	6-5	920	884	36	6-2	0-3	2L
La Salle	3-7	671	680	-9	3-3	0-4	4L
Loyola Chicago	3-8	751	835	-84	3-6	0-2	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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