Southern Indiana vs Eastern Illinois Prediction, Picks & Odds | 21 Feb 2026

College Basketball Betting Preview: Southern Indiana vs Eastern Illinois

The Southern Indiana Screaming Eagles square off against the Eastern Illinois Panthers, with tip-off scheduled for 16:30 on Saturday, February 21.

We’re backing Eastern Illinois against the spread when they meet with Southern Indiana. It could be shrewd to bet on them to cover the appealing -3.5 line, with odds of -118 on offer.

Southern Indiana Screaming Eagles got the win in their previous game. A 77-70 triumph occurred on the road when playing Western Illinois Leathernecks.

Eastern Illinois Panthers lost when they last took to the court. They were turned over 73-70 at home to Morehead State Eagles.

Head-to-Head Statistics

Eastern Illinois have won the last two matchups against Southern Indiana, landing 63-54 and 59-51 (OT) scorelines. Both triumphs came on the road. The previous 6 games featuring these teams have resulted in four Eastern Illinois victories.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Eastern Illinois	11-17	1885	1970	-85	9-5	2-12	1L
Southern Indiana	6-21	1859	1991	-132	3-10	3-11	1W

View Full Standings

Southern Indiana vs Eastern Illinois Prediction & Picks

Gear up for Southern Indiana vs Eastern Illinois with our betting guide, featuring an expert match prediction, scoreline advice and a hand-picked bet builder. Explore each section below for detailed insights.

Game Prediction

Back the moneyline favorites with a -3.5 spread in this college matchup. This is a good number and we are confident Eastern Illinois can cover the line at odds of -118.

Our team of college basketball handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Southern Indiana vs Eastern Illinois stats:

• The -3.5 line has been covered by Eastern Illinois in 6 of their last 10 games at home.
• The +3.5 line hasn’t been covered by USI in 7 of their last 10 games.
• The +3.5 line hasn’t been covered by USI in 14 of their last 20 games.
• The -3.5 line has been covered by Eastern Illinois in 2 consecutive games against USI.

Eastern Illinois -3.5 Probability

The best sportsbooks are estimating that there is a 54.1% chance of this pick winning. After careful examination, our analysts calculate this probability to be closer to 60%. That means we’re regarding it as a value wager.

If you are looking for bigger odds, then you are able to move the line. Choose from a wide range of options and get rewarded if your spread pick exceeds expectations.

Give yourself a head start. Explore the latest free bet promotions and bonus offers in our comprehensive guide.

Our Game Prediction

Eastern Illinois -3.5 @ -118 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Feb 21, 00:03). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Southern Indiana 68 - 75 Eastern Illinois

For those wanting a big return from a small stake, consider the correct score lines. For example, Eastern Illinois can be backed to win 75-68 at huge betting odds.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Southern Indiana vs Eastern Illinois Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

It’s no surprise to find the Moneyline either uncompetitive or not available with many sportsbooks. However, there is a spread where favorites Eastern Illinois and their opponents feature and bettors can work out where the value lies.

The spread currently stands at 4.5 and the total points line is 135.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. If you want to wager Over 135.5, there are odds of -112.

The good news is that you can access a wide range of team props and game lines for most college basketball contests. The best betting apps have a huge range of pre-game and in-game wagering options.

Moneyline

USI

-

Eastern Illinois

-

Point Spread

USI +4.5

-115

Eastern Illinois -4.5

-105

Total Points

Under 135.5

-108

Over 135.5

-112

The best gambling sites offer player prop betting to their customers. These can be a great alternative if you want to focus on an individual’s performance within a game and it often involves wagering over or under a line.

It’s good to consider all wagering options when it comes to college basketball and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether the next shot will be a Two or a Three-pointer.

Latest regular season and playoff games stats.

Southern Indiana Stats

Eastern Illinois Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 137.90 pts in the previous 10 games
• Game Totals on the Road: An average of 138.80 pts in the previous 10 games on the road
• Over 136.5: Covered in 6 of the previous 10 games
• Over 136.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 66.10 pts and allowed 71.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 66.20 pts and allowed 72.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 138.60 pts in the previous 10 games
• Game Totals at Home: An average of 142.90 pts in the previous 10 home games
• Over 136.5: Covered in 7 of the previous 10 games
• Over 136.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 70.50 pts and allowed 68.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 76.80 pts and allowed 66.10 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Ohio Valley	Overall	PF	PA	N. Pts	Home	Away	Strk
UT Martin	20-9	2078	1839	239	11-2	9-7	2L
Tennessee State	18-9	2190	2059	131	10-2	8-7	1W
Southeast Missouri	17-11	2101	1982	119	9-4	8-7	2W
SIU Edwardsville	17-11	2003	1816	187	8-5	9-6	2L
Morehead State	16-12	2130	2120	10	10-2	6-10	4W
Lindenwood	16-12	2213	2056	157	9-4	7-8	2L
Tennessee Tech	12-16	2078	2098	-20	7-6	5-10	2W
Little Rock	11-17	1971	2084	-113	6-4	5-13	1W
Eastern Illinois	11-17	1885	1970	-85	9-5	2-12	1L
Southern Indiana	6-21	1859	1991	-132	3-10	3-11	1W
Western Illinois	4-23	1758	2095	-337	3-9	1-14	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

Top Basketball Pages