San Francisco vs Santa Clara Prediction, Picks & Odds | 28 Jan 2026

College Basketball Betting Preview: San Francisco vs Santa Clara

The San Francisco Dons battle the Santa Clara Broncos, with tip-off scheduled for 23:00 on Wednesday, January 28.

Santa Clara are capable of covering the -9.5 line when they go up against San Francisco. We’re confident of a strong showing and a bet against the spread could be the best play at -120.

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San Francisco Dons were beaten in their previous game and this was on the road. Gonzaga Bulldogs claimed a 68-66 win.

Santa Clara Broncos triumphed in their last game. It was on the road where San Diego Toreros were beaten 85-73.

Head-to-Head Statistics

The last matchup between Santa Clara and San Francisco saw the former win. It was a 77-54 scoreline. We’ve seen six San Francisco wins in the past 10 meetings between the teams.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Santa Clara	17-5	1814	1554	260	12-2	5-3	4W
San Francisco	13-9	1657	1534	123	9-2	4-7	1L

View Full Standings

San Francisco vs Santa Clara Prediction & Picks

Our San Francisco vs Santa Clara betting preview covers everything you need, including a key match prediction, correct score insight and a value-packed bet builder recommendation.

Game Prediction

Santa Clara really stand out in this college contest. Back them at -9.5 on the spread with the confidence that the betting favorites cover the line at -120.

Our basketball predictions are always well-researched, starting with a combination of the latest college hoops team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key San Francisco vs Santa Clara stats:

• The -9.5 line has been covered by Santa Clara in 4 of their last 5 games at home.
• The -9.5 line has been covered by Santa Clara in 6 of their last 10 games.

Santa Clara -9.5 Probability

Based on the odds from the top betting sites, there’s a 54.6% likelihood of our pick delivering a return. However, our cappers think that the probability is close to 60% taking all factors into consideration. This college basketball wager can therefore be backed with confidence.

In the quest to secure bigger odds, there’s the possibility of moving the line. There are plenty of choices when it comes to doing this, so you can choose the option that suits you.

Get ahead of the game by checking our latest guide full of betting offers, welcome bonuses, and free bet deals.

Our Game Prediction

Santa Clara -9.5 @ -120 Bet Now

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Correct Score Prediction

San Francisco 67 - 79 Santa Clara

If you want to take a chance on a correct score, then Santa Clara to enjoy a 79-67 win could be along the right lines. There are enormous odds for this particular outcome.

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San Francisco vs Santa Clara Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

According to the Moneyline betting odds, Santa Clara are red-hot -625 favorites with the sportsbooks and that means a 86% chance of winning this college game. San Francisco are regarded as a long shot to win and you can currently back them at +440.

The spread currently stands at 9.5 and the total points line is 151.5. A Total bet is always available and can often provide value selections. If you fancy Under 151.5, then the odds are -105.

If you’re planning to place a bet on a college basketball matchup, head to the top betting apps and explore the wide range of team props and game lines. Look for the lines that offer the most value.

Moneyline

San Francisco

+440

Santa Clara

-625

Point Spread

San Francisco +9.5

-102

Santa Clara -9.5

-120

Total Points

Under 151.5

-105

Over 151.5

-115

If you have a view on Total Points, Three-Pointers, Assists, Double-Doubles or Triple-Doubles, then the player prop betting could be up your street. It’s a great way of wagering on individual performance.

You don’t have to wait for the final outcome when it comes to college basketball micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Latest regular season and playoff games stats.

San Francisco Stats

Santa Clara Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 145.00 pts in the previous 10 games
• Game Totals on the Road: An average of 142.10 pts in the previous 10 games on the road
• Over 151.5: Covered in 3 of the previous 10 games
• Over 151.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 75.10 pts and allowed 69.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 70.80 pts and allowed 71.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 158.30 pts in the previous 10 games
• Game Totals at Home: An average of 149.30 pts in the previous 10 home games
• Over 151.5: Covered in 8 of the previous 10 games
• Over 151.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 86.40 pts and allowed 71.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 82.00 pts and allowed 67.30 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

West Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Gonzaga	21-1	1955	1463	492	14-0	7-1	14W
Saint Mary's	19-3	1729	1419	310	13-0	6-3	2W
Santa Clara	17-5	1814	1554	260	12-2	5-3	4W
Pacific	14-8	1647	1508	139	10-0	4-8	2W
Seattle	14-8	1632	1478	154	11-4	3-4	1L
San Francisco	13-9	1657	1534	123	9-2	4-7	1L
Loyola Marymount	11-11	1647	1569	78	8-6	3-5	4L
Oregon State	10-12	1541	1644	-103	9-7	1-5	2L
Portland	9-12	1605	1653	-48	8-5	1-7	1L
San Diego	9-13	1674	1708	-34	8-5	1-8	1L
Washington State	8-13	1685	1728	-43	6-5	2-8	1W
Pepperdine	6-16	1530	1689	-159	5-7	1-9	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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