Creighton vs Louisville Prediction, Picks & Odds | 20 Mar 2025

No. 9 Creighton Bluejays (24-10, 15-5 Big East) play No. 8 Louisville Cardinals (27-7, 18-2 ACC) in this South Region first round matchup at Rupp Arena in Lexington, Kentucky.

The best bet could be taking Louisville to simply achieve a victory over Creighton. Our prediction can be taken at -133 on the Moneyline which yields a potentially nice return.

Creighton Bluejays were defeated in their previous game. On the road, they suffered a 82-66 reverse against St. John's Red Storm.

Louisville Cardinals were defeated in their last game. On the road, they suffered a 73-62 reverse against Duke Blue Devils.

NCAAB Regular Season	Overall	PF	PA	N. Pts	Home	Away	Strk
Louisville	23-9	2724	2304	420	16-2	7-7	3W
Creighton	15-16	2343	2329	14	11-6	4-10	1W

View Full Standings

Creighton vs Louisville Prediction & Picks

The road team look opposable, so we’re going to make Louisville our pick for this college showdown. You can currently get -133 for this selection on the Moneyline which looks good value.

The college basketball picks are only provided once we have a handle on the team news and the latest form guide. We are also on point when it comes to the most valuable stats.

Key Creighton vs Louisville stats:

• Louisville have won 9 of their last 10 games.
• Louisville have won 18 of their last 20 games.

Louisville Moneyline Probability

The sportsbooks are estimating that there is a 57.1% likelihood of this pick winning. However, our cappers have this figure between 60-65% based on their in-depth research. This college basketball bet can therefore be backed with confidence.

The spread provides you with the chance to get more juice on your wagers. You can move the betting line for Louisville and choose the odds to suit you.

Our Game Prediction

Louisville Moneyline @ -133 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 19, 03:52). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Chucky Hepburn Under 4.5 Rebounds -154

Chucky Hepburn (Louisville) can be backed to have Under 4.5 rebounds at -154. We can’t pass up the chance to back Unders considering the Player Rebounds line that is on offer.

Latest Chucky Hepburn Player Prop Odds

Points

Over 15.5

-125

Under 15.5

-103

Assists

Over 5.5

+118

Under 5.5

-154

Rebounds

Over 3.5

-143

Under 3.5

+110

---

Reyne Smith Over 11.5 Points -103

Reyne Smith (Louisville) can be wagered to register Over 11.5 points at -103. There’s an opportunity to wager on Player Points and the total looks attractive for this player.

Latest Reyne Smith Player Prop Odds

Points

Over 11.5

+118

Under 11.5

-154

Assists

Over 0.5

+110

Under 0.5

-145

Rebounds

Over 2.5

-123

Under 2.5

-105

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Creighton 69 - 71 Louisville

We’re expecting a close contest so it might be worth going for Louisville to win by a 71-69 scoreline. You can get a massive price and we should hopefully get a run for our money.

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Creighton vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

If you want to bet on Louisville, then Moneyline odds of -147 are on offer, although Creighton are a +122 chance. There is a 60% chance of the hosts winning according to the top sportsbooks.

The current spread is 2.5 and total points is 145.5. There are many ways to bet on basketball including the Totals. Those expecting a low total can back Under 145.5 at -108.

If you think Louisville can reach 20 points first, then odds of -160 are available for the favorites to win. On the flip side, Creighton are +120 to reach this total before their opponents.

Whether you are wagering pre-game or in-game, you can feast on plenty of game lines and team props. The selections are practically endless and it’s great to have so many options.

Moneyline

Creighton

+122

Louisville

-147

Point Spread

Creighton +2.5

-105

Louisville -2.5

-115

Total Points

Under 145.5

-108

Over 145.5

-112

The favorite to hit the most buckets is Ryan Kalkbrenner. Odds of -111 can be found for him scoring Over 21.5 points and there is -116 for him to go Under.

Ryan Kalkbrenner (Creighton)

Over 21.5

-111

Under 21.5

-116

Terrence Edwards Jr. (Louisville)

Over 18.5

-114

Under 18.5

-114

Chucky Hepburn (Louisville)

Over 15.5

-125

Under 15.5

-103

Steven Ashworth (Creighton)

Over 15.5

+110

Under 15.5

-143

J'Vonne Hadley (Louisville)

Over 13.5

+106

Under 13.5

-137

Jamiya Neal (Creighton)

Over 12.5

-114

Under 12.5

-114

Reyne Smith (Louisville)

Over 11.5

+118

Under 11.5

-154

Jackson McAndrew (Creighton)

Over 7.5

-111

Under 7.5

-116

Jasen Green (Creighton)

Over 6.5

-125

Under 6.5

-103

James Scott (Louisville)

Over 6.5

+103

Under 6.5

-133

Steven Ashworth (Creighton)

Over 6.5

+117

Under 6.5

-152

Chucky Hepburn (Louisville)

Over 5.5

+118

Under 5.5

-154

Jamiya Neal (Creighton)

Over 4.5

+109

Under 4.5

-141

Terrence Edwards Jr. (Louisville)

Over 2.5

-115

Under 2.5

-112

Ryan Kalkbrenner (Creighton)

Over 1.5

-118

Under 1.5

-110

J'Vonne Hadley (Louisville)

Over 1.5

-111

Under 1.5

-116

Jasen Green (Creighton)

Over 1.5

+132

Under 1.5

-172

James Scott (Louisville)

Over 1.5

+139

Under 1.5

-182

Reyne Smith (Louisville)

Over 0.5

+110

Under 0.5

-145

Jackson McAndrew (Creighton)

Over 0.5

+115

Under 0.5

-154

Ryan Kalkbrenner (Creighton)

Over 8.5

-125

Under 8.5

-103

J'Vonne Hadley (Louisville)

Over 6.5

-135

Under 6.5

+104

Jamiya Neal (Creighton)

Over 5.5

-147

Under 5.5

+113

James Scott (Louisville)

Over 5.5

-149

Under 5.5

+115

Terrence Edwards Jr. (Louisville)

Over 4.5

-106

Under 4.5

-122

Steven Ashworth (Creighton)

Over 4.5

+120

Under 4.5

-156

Jackson McAndrew (Creighton)

Over 4.5

-149

Under 4.5

+115

Jasen Green (Creighton)

Over 4.5

+115

Under 4.5

-149

Chucky Hepburn (Louisville)

Over 3.5

-143

Under 3.5

+110

Reyne Smith (Louisville)

Over 2.5

-123

Under 2.5

-105

Micro betting provides a rollercoaster ride for college basketball bettors. It can be great to enjoy the live lines, with the opportunity to bet on the Next Field Goal. Watch the live action before deciding which way to go.

Latest regular season and playoff games stats.

Creighton Stats

Louisville Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games

Moneyline

• 9 wins and 1 defeat in the last 10 games

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games

Point Spread

• -2.5 Betting Line: Have covered the spread in 8 of the last 10 games

Total Points

• Game Totals: An average of 146.90 pts in the previous 10 games
• Over 145.5: Covered in 5 of the previous 10 games
• Team Totals: Have scored an average of 74.30 pts and allowed 72.60 pts in the last 10 games

Total Points

• Game Totals: An average of 144.70 pts in the previous 10 games
• Over 145.5: Covered in 6 of the previous 10 games
• Team Totals: Have scored an average of 77.10 pts and allowed 67.60 pts in the last 10 games

NCAAB Regular Season Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	29-2	2571	1937	634	18-0	11-2	8W
Virginia	27-4	2507	2116	391	17-1	10-3	2W
Miami	24-7	2564	2192	372	15-4	9-3	1L
North Carolina	24-7	2474	2202	272	19-0	5-7	1L
Clemson	23-9	2380	2117	263	16-3	7-6	2W
Louisville	23-9	2724	2304	420	16-2	7-7	3W
California	21-11	2492	2344	148	17-4	4-7	2L
NC State	20-12	2688	2444	244	13-7	7-5	1W
Stanford	20-12	2431	2326	105	12-7	8-5	1L
SMU	20-13	2779	2561	218	17-3	3-10	1L
Virginia Tech	19-13	2521	2396	125	15-4	4-9	2L
Florida State	18-14	2573	2492	81	12-8	6-6	4W
Wake Forest	17-16	2602	2543	59	12-6	5-10	1L
Syracuse	15-17	2400	2376	24	12-6	3-11	6L
Notre Dame	13-18	2308	2335	-27	11-7	2-11	2L
Pittsburgh	13-20	2327	2370	-43	8-10	5-10	1L
Boston College	11-20	2090	2191	-101	10-10	1-10	1W
Georgia Tech	11-20	2287	2400	-113	10-10	1-10	12L

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	27-4	2423	2023	400	16-2	11-2	1L
St. John's	25-6	2538	2187	351	15-3	10-3	3W
Villanova	24-7	2405	2187	218	15-3	9-4	2W
Seton Hall	20-11	2181	2017	164	12-5	8-6	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Creighton	15-16	2343	2329	14	11-6	4-10	1W
Providence	15-17	2743	2687	56	10-7	5-10	1W
Georgetown	15-17	2374	2348	26	10-8	5-9	2W
Xavier	15-17	2518	2568	-50	13-7	2-10	1W
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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