Creighton vs Louisville Prediction, Picks & Odds | 20 Mar 2025

No. 9 Creighton Bluejays (24-10, 15-5 Big East) play No. 8 Louisville Cardinals (27-7, 18-2 ACC) in this South Region first round matchup at Rupp Arena in Lexington, Kentucky.

The best bet could be taking Louisville to simply achieve a victory over Creighton. Our prediction can be taken at -133 on the Moneyline which yields a potentially nice return.

Creighton Bluejays were defeated in their previous game. On the road, they suffered a 82-66 reverse against St. John's Red Storm.

Louisville Cardinals were defeated in their last game. On the road, they suffered a 73-62 reverse against Duke Blue Devils.

NCAAB Regular Season	Overall	PF	PA	N. Pts	Home	Away	Strk
Louisville	12-4	1413	1114	299	9-1	3-3	1W
Creighton	10-7	1312	1218	94	8-2	2-5	1L

View Full Standings

Creighton vs Louisville Prediction & Picks

The road team look opposable, so we’re going to make Louisville our pick for this college showdown. You can currently get -133 for this selection on the Moneyline which looks good value.

The college basketball picks are only provided once we have a handle on the team news and the latest form guide. We are also on point when it comes to the most valuable stats.

Key Creighton vs Louisville stats:

• Louisville have won 9 of their last 10 games.
• Louisville have won 18 of their last 20 games.

Louisville Moneyline Probability

The sportsbooks are estimating that there is a 57.1% likelihood of this pick winning. However, our cappers have this figure between 60-65% based on their in-depth research. This college basketball bet can therefore be backed with confidence.

The spread provides you with the chance to get more juice on your wagers. You can move the betting line for Louisville and choose the odds to suit you.

Our Game Prediction

Louisville Moneyline @ -133 Bet Now

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Player Prop Picks

Top Pick: Chucky Hepburn Under 4.5 Rebounds -154

Chucky Hepburn (Louisville) can be backed to have Under 4.5 rebounds at -154. We can’t pass up the chance to back Unders considering the Player Rebounds line that is on offer.

Latest Chucky Hepburn Player Prop Odds

Points

Over 15.5

-125

Under 15.5

-103

Assists

Over 5.5

+118

Under 5.5

-154

Rebounds

Over 3.5

-143

Under 3.5

+110

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Reyne Smith Over 11.5 Points -103

Reyne Smith (Louisville) can be wagered to register Over 11.5 points at -103. There’s an opportunity to wager on Player Points and the total looks attractive for this player.

Latest Reyne Smith Player Prop Odds

Points

Over 11.5

+118

Under 11.5

-154

Assists

Over 0.5

+110

Under 0.5

-145

Rebounds

Over 2.5

-123

Under 2.5

-105

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Correct Score Prediction

Creighton 69 - 71 Louisville

We’re expecting a close contest so it might be worth going for Louisville to win by a 71-69 scoreline. You can get a massive price and we should hopefully get a run for our money.

Creighton vs Louisville Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

If you want to bet on Louisville, then Moneyline odds of -147 are on offer, although Creighton are a +122 chance. There is a 60% chance of the hosts winning according to the top sportsbooks.

The current spread is 2.5 and total points is 145.5. There are many ways to bet on basketball including the Totals. Those expecting a low total can back Under 145.5 at -108.

If you think Louisville can reach 20 points first, then odds of -160 are available for the favorites to win. On the flip side, Creighton are +120 to reach this total before their opponents.

Whether you are wagering pre-game or in-game, you can feast on plenty of game lines and team props. The selections are practically endless and it’s great to have so many options.

Moneyline

Creighton

+122

Louisville

-147

Point Spread

Creighton +2.5

-105

Louisville -2.5

-115

Total Points

Under 145.5

-108

Over 145.5

-112

The favorite to hit the most buckets is Ryan Kalkbrenner. Odds of -111 can be found for him scoring Over 21.5 points and there is -116 for him to go Under.

Ryan Kalkbrenner (Creighton)

Over 21.5

-111

Under 21.5

-116

Terrence Edwards Jr. (Louisville)

Over 18.5

-114

Under 18.5

-114

Chucky Hepburn (Louisville)

Over 15.5

-125

Under 15.5

-103

Steven Ashworth (Creighton)

Over 15.5

+110

Under 15.5

-143

J'Vonne Hadley (Louisville)

Over 13.5

+106

Under 13.5

-137

Jamiya Neal (Creighton)

Over 12.5

-114

Under 12.5

-114

Reyne Smith (Louisville)

Over 11.5

+118

Under 11.5

-154

Jackson McAndrew (Creighton)

Over 7.5

-111

Under 7.5

-116

Jasen Green (Creighton)

Over 6.5

-125

Under 6.5

-103

James Scott (Louisville)

Over 6.5

+103

Under 6.5

-133

Steven Ashworth (Creighton)

Over 6.5

+117

Under 6.5

-152

Chucky Hepburn (Louisville)

Over 5.5

+118

Under 5.5

-154

Jamiya Neal (Creighton)

Over 4.5

+109

Under 4.5

-141

Terrence Edwards Jr. (Louisville)

Over 2.5

-115

Under 2.5

-112

Ryan Kalkbrenner (Creighton)

Over 1.5

-118

Under 1.5

-110

J'Vonne Hadley (Louisville)

Over 1.5

-111

Under 1.5

-116

Jasen Green (Creighton)

Over 1.5

+132

Under 1.5

-172

James Scott (Louisville)

Over 1.5

+139

Under 1.5

-182

Reyne Smith (Louisville)

Over 0.5

+110

Under 0.5

-145

Jackson McAndrew (Creighton)

Over 0.5

+115

Under 0.5

-154

Ryan Kalkbrenner (Creighton)

Over 8.5

-125

Under 8.5

-103

J'Vonne Hadley (Louisville)

Over 6.5

-135

Under 6.5

+104

Jamiya Neal (Creighton)

Over 5.5

-147

Under 5.5

+113

James Scott (Louisville)

Over 5.5

-149

Under 5.5

+115

Terrence Edwards Jr. (Louisville)

Over 4.5

-106

Under 4.5

-122

Steven Ashworth (Creighton)

Over 4.5

+120

Under 4.5

-156

Jackson McAndrew (Creighton)

Over 4.5

-149

Under 4.5

+115

Jasen Green (Creighton)

Over 4.5

+115

Under 4.5

-149

Chucky Hepburn (Louisville)

Over 3.5

-143

Under 3.5

+110

Reyne Smith (Louisville)

Over 2.5

-123

Under 2.5

-105

Micro betting provides a rollercoaster ride for college basketball bettors. It can be great to enjoy the live lines, with the opportunity to bet on the Next Field Goal. Watch the live action before deciding which way to go.

Latest regular season and playoff games stats.

Creighton Stats

Louisville Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games

Moneyline

• 9 wins and 1 defeat in the last 10 games

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games

Point Spread

• -2.5 Betting Line: Have covered the spread in 8 of the last 10 games

Total Points

• Game Totals: An average of 146.90 pts in the previous 10 games
• Over 145.5: Covered in 5 of the previous 10 games
• Team Totals: Have scored an average of 74.30 pts and allowed 72.60 pts in the last 10 games

Total Points

• Game Totals: An average of 144.70 pts in the previous 10 games
• Over 145.5: Covered in 6 of the previous 10 games
• Team Totals: Have scored an average of 77.10 pts and allowed 67.60 pts in the last 10 games

NCAAB Regular Season Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	15-1	1388	1065	323	10-0	5-1	4W
Miami	14-2	1411	1107	304	11-1	3-1	9W
Virginia	14-2	1361	1069	292	11-0	3-2	3W
North Carolina	14-2	1307	1073	234	12-0	2-2	1W
Clemson	14-3	1323	1116	207	10-0	4-3	7W
Virginia Tech	13-4	1399	1254	145	11-1	2-3	1W
Stanford	13-4	1308	1201	107	8-3	5-1	1L
California	13-4	1357	1190	167	13-1	0-3	2L
Louisville	12-4	1413	1114	299	9-1	3-3	1W
SMU	12-4	1426	1233	193	11-0	1-4	2L
NC State	12-5	1471	1211	260	9-3	3-2	2W
Syracuse	11-5	1196	1051	145	8-2	3-3	2W
Notre Dame	10-6	1176	1077	99	8-2	2-4	2L
Wake Forest	10-7	1390	1282	108	8-3	2-4	2L
Georgia Tech	10-7	1292	1225	67	10-3	0-4	2L
Pittsburgh	7-9	1171	1113	58	6-5	1-4	3L
Florida State	7-9	1327	1301	26	7-5	0-4	3L
Boston College	7-9	1104	1086	18	6-6	1-3	3L

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	16-1	1358	1076	282	10-1	6-0	12W
Seton Hall	14-2	1181	1003	178	8-1	6-1	3W
Villanova	13-3	1248	1085	163	9-1	4-2	1W
St. John's	11-5	1370	1163	207	7-3	4-2	2W
Butler	10-6	1345	1207	138	10-3	0-3	3L
Creighton	10-7	1312	1218	94	8-2	2-5	1L
DePaul	10-7	1239	1167	72	9-4	1-3	1L
Xavier	10-7	1305	1287	18	9-4	1-3	1W
Georgetown	9-7	1234	1184	50	7-4	2-3	3L
Providence	8-8	1426	1359	67	6-3	2-5	2L
Marquette	6-11	1269	1298	-29	6-6	0-5	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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