Liverpool vs Southampton Prediction, Betting Tips, Lineups & Odds | 23 Sep 2025

EFL Cup Betting Preview: Liverpool vs Southampton

Premier League leaders Liverpool host Championship club Southampton in this EFL Cup third round clash at Anfield, with kick-off set for 15:00 on Tuesday 23 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and confirmed lineups.

Reds Look Set for a Big Win

Liverpool -2.25 are available at -116 on the Asian Handicap and we need a three-goal winning margin to land a full return. However, we get half our stake returned if the Reds win by two goals against Southampton.

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8 Triumphs for Liverpool in Previous 10 H2H Clashes

Liverpool were winners last time out. Landing a 2-1 Premier League home triumph in the Merseyside derby against Everton at Anfield. Arne Slot's team had most of the ball recording 57% possession and three shots on target, with Ryan Gravenberch and Hugo Ekitike scoring one goal apiece.

Southampton were defeated in their previous game. On their travels, they suffered a 3-1 Championship loss against Hull City at MKM Stadium. The Saints had four shots on goal and enjoyed 71% possession, with Adam Armstrong on the scoresheet.

In the last round of the EFL Cup, Southampton overcame Norwich City 3-0 away.

Head-to-Head Statistics

Liverpool have won three on the spin against Southampton. In the last encounter, Liverpool claimed a 3-1 Premier League victory when hosting at Anfield. The past 10 H2H matches have involved eight Liverpool wins, one Southampton victory and one draw.

Liverpool have 6 wins, 2 losses and 2 draws, averaging 2.2 goals from 4.7 shots on goal and 15.2 attempts. The Reds have averaged 60.7% possession, 506.1 passes and 5.9 corners per game, with their opponents scoring 1.5 goals from 4.3 shots on goal, 11.3 attempts and 3.6 corners.

Top goalscorer Mohamed Salah has found the net 4 times, with Hugo Ekitike and Cody Gakpo scoring 3 each. Cody Gakpo and Dominik Szoboszlai have been top assistors on 3, with goalkeeper Alisson Becker keeping 2 clean sheets.

Southampton have 1 victory, 2 defeats and 3 draws, with an average of 1.2 goals from 15.2 attempts and 4.5 shots on goal. Will Still's men average 61.2% possession, 6.2 corners awarded and 3.5 corners against them, while conceding 1.5 goals from 11.5 attempts and 2.8 shots on goal.

Ryan Manning has scored 2 goals, followed by Adam Armstrong, Cameron Archer, Taylor Harwood-Bellis and Jay Robinson on 1. Ryan Fraser has been the top assist maker with 2 in the last 6 games.

Confirmed Lineups

Liverpool confirmed lineup (4-2-3-1): Giorgi Mamardashvili (GK), Jeremie Frimpong, Giovanni Leoni, Joseph Gomez, Andrew Robertson, Wataru Endo, Curtis Jones, Federico Chiesa, Trey Nyoni, Rio Ngumoha, Alexander Isak.

Southampton confirmed lineup (3-2-4-1): Alex McCarthy (GK), Ronnie Edwards, Nathan Wood, Joshua Quarshie, Elias Jelert, Ryan Manning, Adam Armstrong, Caspar Jander, Flynn Downes, Leo Scienza, Cameron Archer.

Liverpool vs Southampton Prediction & Betting Tips

Join us as we dissect the best Liverpool vs Southampton betting tips — from our expert match prediction and correct score advice to a sharp corners pick, top player prop insights and a ready-made bet builder.

Match Prediction

We’re going for Liverpool -2.25 in the expectation that the favourites achieve a win with something to spare. The EFL Cup encounter should go in their favour and we’ll take the odds of -116.

Our football experts are keen to follow the latest form and understand any patterns that emerge. The same applies to injuries that could affect key players. Combined with the best EFL Cup stats, there is plenty of information to make a verdict.

Key Liverpool vs Southampton EFL Cup & league stats:

• Liverpool have opened the 2025/26 campaign with five consecutive Premier League wins.
• Liverpool have won the last 3 H2H meetings against Southampton
• The -2.25 line has been covered by Liverpool in 3 of their last 20 games at home.

Liverpool -2.25 Probability

The best betting apps make it a 53.8% chance that our pick is settled as a winner. However, our tipsters research has found that the actual probability is closer to 60%. This is why we can recommend this wager.

Bettors have the flexibility of being able to buy or sell goals depending on whether they want a safer or a riskier wager, with the odds moving according to the line.

Before you place your next wager, browse our guide for top betting offers including the latest free bets and welcome bonuses.

Our Match Prediction

Liverpool Asian Hcp -2.25 @ -116 Bet Now

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Correct Score Prediction

Liverpool 4 - 0 Southampton

Liverpool are available at +850 to secure a 4-0 victory. Many bettors enjoy a correct score wager and there are some nice potential returns to be had.

Player Prop Picks

Top Pick: Federico Chiesa Under 0.5 Shots On Target +120

Federico Chiesa (Liverpool) hasn’t managed a shot on goal in three straight matches. There’s a reasonable prospect that he will fall short of the mark, with odds of +120 on offer that he doesn’t cover the Shots on Target line.

Latest Federico Chiesa Player Prop Odds

Goalscorer

Anytime

+143

First

+440

Shots On Target

Over 0.5

-208

Under 0.5

+120

Shots

Over 3.5

+132

Under 3.5

-

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Hugo Ekitike to Score +105

Hugo Ekitike (Liverpool) has been among the goals in three of his past five matches. When it comes to him scoring, we think that the +105 available is attractive when betting on the Anytime Goalscorer market.

Latest Hugo Ekitike Player Prop Odds

Goalscorer

Anytime

+117

First

+350

Shots On Target

Over 1.5

+160

Under 1.5

-263

Shots

Over 3.5

+128

Under 3.5

-

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Corners Prediction

Liverpool Under 7.5 Corners -150

In their past three home games, Liverpool have not covered the 7.5 corners line, while the previous ten Southampton matches have involved them conceding under 7.5 corners. There’s a chance to go under the Liverpool Team Corners line and we’re confident this will happen, with odds of -150 on offer.

EFL Cup & League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Liverpool

Total

9.50 5.90 3.60

Home

11.00 6.70 4.30

Away

9.60 5.90 3.70

Southampton

Total

8.40 5.00 3.40

Home

9.80 5.80 4.00

Away

8.14 4.43 3.71

Latest Corner Odds

Total Corners

Over 11.5

+104

Under 11.5

-143

Liverpool Corners

Over 7.5

-100

Under 7.5

-138

Southampton Corners

Over 2.5

-163

Under 2.5

+120

Most Corners

1

-588

X

+1050

2

+525

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Liverpool vs Southampton Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Betting Sites Make Liverpool Massive Favourites

The latest betting odds suggest that Liverpool are convincing -476 favourites to claim a victory and that means a 83% probability of coming out on top in this EFL Cup encounter. Southampton are the underdogs at +1150 which implies a low percentage prospect of winning.

There’s a nice alternative in the form of the Half-Time Result market. This allows you to back Liverpool at -182 to lead at the break or alternatively opt for Southampton at +700. The draw is the third option at +205.

Over 2.5 Goals is the market leader and that means three or more goals are predicted. If you’re looking to wager on Both Teams to Score, there’s not a lot of difference between Yes and No.

There are hundreds of markets from which to select your preferred wager when it comes to EFL Cup games. The best football betting sites push the boat out to provide lots of choice.

Full-Time Result

1

-476

X

+600

2

+1150

Half-Time Result

1

-182

X

+205

2

+700

Double Chance

1X

-3333

12

-1000

X2

+310

Draw No Bet

1

-1667

2

+650

Asian Handicap

1 Hcp -2

-110

2 Hcp +2

-112

Total Goals

Under 2.5

+210

Over 2.5

-286

Both Teams to Score

Yes

-119

No

-114

Alexander Isak Heads First Goalscorer Market

There’s the chance to back Alexander Isak at +250 to be the First Goalscorer. He’s the favourite and available at similar odds to find the net last instead.

Alexander Isak (Liverpool)

First

-161

Anytime

+250

Mohamed Salah (Liverpool)

First

-111

Anytime

+320

Hugo Ekitike (Liverpool)

First

+117

Anytime

+350

Rio Ngumoha (Liverpool)

First

+143

Anytime

+400

Federico Chiesa (Liverpool)

First

+143

Anytime

+440

Cody Gakpo (Liverpool)

First

+205

Anytime

+550

Florian Wirtz (Liverpool)

First

+220

Anytime

+600

Treymaurice Nyoni (Liverpool)

First

+245

Anytime

+750

Adam Armstrong (Southampton)

First

+335

Anytime

+1000

Dominik Szoboszlai (Liverpool)

First

+370

Anytime

+1100

Jeremie Frimpong (Liverpool)

First

+390

Anytime

+1200

Ross Cameron Stewart (Southampton)

First

+450

Anytime

+1300

Curtis Jones (Liverpool)

First

+450

Anytime

+1300

Cameron Archer (Southampton)

First

+460

Anytime

+1400

Leo Scienza (Southampton)

First

+500

Anytime

+1400

Alexis Mac Allister (Liverpool)

First

+500

Anytime

+1500

Finn Azaz (Southampton)

First

+650

Anytime

+1800

Joe Gomez (Liverpool)

First

+650

Anytime

+2200

Conor Bradley (Liverpool)

First

+700

Anytime

+2000

Milos Kerkez (Liverpool)

First

+750

Anytime

+2200

Virgil van Dijk (Liverpool)

First

+750

Anytime

+2200

Ryan Gravenberch (Liverpool)

First

+800

Anytime

+2200

Ryan Fraser (Southampton)

First

+850

Anytime

+2200

Rio Ngumoha (Liverpool)

Over 0.5

-213

Under 0.5

+120

Federico Chiesa (Liverpool)

Over 0.5

-208

Under 0.5

+120

Cody Gakpo (Liverpool)

Over 0.5

-159

Under 0.5

+102

Florian Wirtz (Liverpool)

Over 0.5

-143

Under 0.5

-109

Alexander Isak (Liverpool)

Over 1.5

-111

Under 1.5

-152

Treymaurice Nyoni (Liverpool)

Over 0.5

-111

Under 0.5

-154

Adam Armstrong (Southampton)

Over 0.5

-111

Under 0.5

-154

Curtis Jones (Liverpool)

Over 0.5

+112

Under 0.5

-192

Mohamed Salah (Liverpool)

Over 1.5

+115

Under 1.5

-185

Ross Cameron Stewart (Southampton)

Over 0.5

+130

Under 0.5

-208

Cameron Archer (Southampton)

Over 0.5

+135

Under 0.5

-238

Dominik Szoboszlai (Liverpool)

Over 0.5

+140

Under 0.5

-233

Leo Scienza (Southampton)

Over 0.5

+145

Under 0.5

-263

Jeremie Frimpong (Liverpool)

Over 0.5

+150

Under 0.5

-270

Hugo Ekitike (Liverpool)

Over 1.5

+160

Under 1.5

-263

Finn Azaz (Southampton)

Over 0.5

+185

Under 0.5

-313

Alexis Mac Allister (Liverpool)

Over 0.5

+210

Under 0.5

-370

Ryan Fraser (Southampton)

Over 0.5

+240

Under 0.5

-455

Conor Bradley (Liverpool)

Over 0.5

+280

Under 0.5

-588

Joe Gomez (Liverpool)

Over 0.5

+320

Under 0.5

-909

Milos Kerkez (Liverpool)

Over 0.5

+350

Under 0.5

-769

Virgil van Dijk (Liverpool)

Over 0.5

+350

Under 0.5

-833

Ryan Gravenberch (Liverpool)

Over 0.5

+350

Under 0.5

-833

Alexander Isak (Liverpool)

Over 3.5

+125

Under 3.5

-

Hugo Ekitike (Liverpool)

Over 3.5

+128

Under 3.5

-

Federico Chiesa (Liverpool)

Over 3.5

+132

Under 3.5

-

Mohamed Salah (Liverpool)

Over 3.5

+107

Under 3.5

-

Rio Ngumoha (Liverpool)

Over 2.5

-114

Under 2.5

-

Cody Gakpo (Liverpool)

Over 2.5

+108

Under 2.5

-

Florian Wirtz (Liverpool)

Over 2.5

+135

Under 2.5

-

Curtis Jones (Liverpool)

Over 1.5

+118

Under 1.5

-

Finn Azaz (Southampton)

Over 1.5

+150

Under 1.5

-

Leo Scienza (Southampton)

Over 1.5

-109

Under 1.5

-

Cameron Archer (Southampton)

Over 1.5

+102

Under 1.5

-

Dominik Szoboszlai (Liverpool)

Over 1.5

+118

Under 1.5

-

Ross Cameron Stewart (Southampton)

Over 1.5

+102

Under 1.5

-

Jeremie Frimpong (Liverpool)

Over 1.5

+135

Under 1.5

-

Adam Armstrong (Southampton)

Over 1.5

-167

Under 1.5

-

Treymaurice Nyoni (Liverpool)

Over 1.5

-141

Under 1.5

-

Alexis Mac Allister (Liverpool)

Over 0.5

-192

Under 0.5

-

Joe Gomez (Liverpool)

Over 0.5

+104

Under 0.5

-

Ryan Fraser (Southampton)

Over 0.5

-167

Under 0.5

-

Latest EFL Cup and domestic league stats. Full Time Result, Goals, Corners and Possession.

Liverpool Stats

Southampton Stats

Full-Time Result

• 6 wins, 2 defeats and 2 draws in the previous 10 matches
• 8 wins and 2 draws in the previous 10 home matches

Full-Time Result

• 1 win, 2 defeats and 3 draws in the previous 6 matches
• 1 defeat and 2 draws in the previous 3 away matches

Goals

• An average of 2.20 goals scored and 1.50 conceded in the previous 10 matches
• An average of 2.30 goals scored and 0.90 conceded in the previous 10 home matches
• An average of 3.70 goals per game in the previous 10 matches
• An average of 3.20 goals per game in the previous 10 home matches
• BTTS Yes in 8 of the previous 10 matches
• BTTS Yes in 7 of the previous 10 home matches
• Over 2.5 Goals in 7 of the previous 10 matches
• Over 2.5 Goals in 6 of the previous 10 home matches

Goals

• An average of 1.17 goals scored and 1.50 conceded in the previous 6 matches
• An average of 1.33 goals scored and 2.00 conceded in the previous 3 away matches
• An average of 2.67 goals per game in the previous 6 matches
• An average of 3.33 goals per game in the previous 3 away matches
• BTTS Yes in 5 of the previous 6 matches
• BTTS Yes in 3 of the previous 3 away matches
• Over 2.5 Goals in 4 of the previous 6 matches
• Over 2.5 Goals in 2 of the previous 3 away matches

Corners

• An average of 5.90 corners awarded and 3.60 corners conceded in the last 10 matches
• An average of 6.70 corners awarded and 3.60 corners against in the last 10 home matches
• An average of 9.50 corners awarded in the last 10 matches
• An average of 10.30 corners awarded in the last 10 home matches
• Had the most corners in 6 and least corners in 3 of the last 10 matches
• Had the most corners in 8 and least corners in 2 of the last 10 home matches

Corners

• An average of 6.17 corners awarded and 3.50 corners conceded in the last 6 matches
• An average of 5.33 corners awarded and 3.00 corners against in the last 3 away matches
• An average of 9.67 corners awarded in the last 6 matches
• An average of 8.33 corners awarded in the last 3 away matches
• Had the most corners in 6 and least corners in 0 of the last 6 matches
• Had the most corners in 3 and least corners in 0 of the last 3 away matches

Possession

• An average of 60.70% possession in the last 10 matches
• An average of 60.80% possession in the last 10 home matches
• Most possession in 9 of the last 10 matches
• Most possession in 9 of the last 10 home matches

Possession

• An average of 61.17% possession in the last 6 matches
• An average of 55.67% possession in the last 3 away matches
• Most possession in 4 of the last 6 matches
• Most possession in 1 of the last 3 away matches

Liverpool vs Southampton Lineups & Team News

Double-check the Liverpool vs Southampton team news before placing your bets. We’ll share the predicted and confirmed lineups for the EFL Cup together with updated injury news.