Anderlecht vs Lyon Prediction, Betting Tips, Lineups & Odds | 16 Sep 2026

Anderlecht vs Lyon Predictions

Main Match Prediction

Anderlecht Asian Hcp +0.5 @ -120

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We’ll take Anderlecht to get the better of Lyon on the Asian Handicap, with odds of -120 available that the home team win with a +0.5 goal start. If they avoid defeat, then we will get paid out with this wager.

Read on for our full Anderlecht vs Lyon betting analysis, featuring the reasoning behind our main match prediction, alongside our correct score prediction, player prop picks, corners prediction and bet builder tips.

Anderlecht vs Lyon Preview

Belgian Pro League side Anderlecht host French Ligue 1 club Lyon at Lotto Park, with kick-off set for 15:00 on Wednesday 16 September.

Anderlecht won last time out by a 1-0 Pro League scoreline. It was on their travels against Mechelen at Argosstadion Achter de Kazerne. Vitor Bruno's side enjoyed 66% possession and had three shots on target, with a 43rd minute winner from Tawfik Bentayeb proving the difference.

Lyon drew on their travels in their previous game. A 0-0 Ligue 1 scoreline was played out against Paris FC at Stade Jean Bouin. OL had 44% of possession and one shot on goal.

Europa League		G	W	D	L	GF	GA	GD	GD	P
1	Lyon	0	0	0	0	0	0	0	0:0	0
1	Anderlecht	0	0	0	0	0	0	0	0:0	0

View Full Table

4 wins, 3 losses and 3 draws, averaging 1.1 goals from 5.0 shots on goal and 15.0 attempts. Anderlecht have had 53.3% possession and 5.4 corners per game. On average, they have conceded 1.4 goals from 3.7 shots on goal and 11.9 attempts, while the opposition have been awarded 3.9 corners.

Top goalscorer Danylo Sikan has found the net 3 times, Adriano Bertaccini 2, with Tawfik Bentayeb and two other players on 1. Ali Maamar is the top assists maker on 4.

Lyon have 6 victories, 2 defeats and 2 draws, with an average of 1.8 goals from 4.7 shots on goal and 12.8 attempts. There’s been an average of 51.3% possession, 440.5 passes, 7.2 corners taken and 6.2 corners against, while they’ve conceded 1.3 goals from 4.2 shots on goal and 12.0 attempts.

The leading scorers have been Corentin Tolisso and Roman Yaremchuk with 4, while Afonso Moreira has 2. Corentin Tolisso is top assists provider with 4, while Dominik Greif and Remy Descamps have collectively recorded 3 clean sheets in the previous 10 games.

Predicted & Confirmed Lineups

Anderlecht predicted lineup (4-4-2): Colin Coosemans (GK), Ali Maamar, Giulian Biancone, Leo Petrot, Ludwig Augustinsson, Marten Winkler, Romeo Amane, Marco Kana, Oliver Antman, Tawfik Bentayeb, Danylo Sikan.

Lyon predicted lineup (4-2-3-1): Dominik Greif (GK), Zachary Athekame, Felix Bacher, Moussa Niakhate, Abner Vinicius, Mads Bidstrup, Tyler Morton, Ernest Nuamah, Corentin Tolisso, Pavel Sulc, Loïs Openda.

Main Match Prediction

Anderlecht are a confident choice with a +0.5 goal start. The home team should be able to win or draw this Europa League game, with this Asian Handicap prediction looking like a value bet at -120.

Key stats supporting our main match prediction (domestic league and Europa League matches):

• The +0.5 line has been covered by Anderlecht in 5 consecutive games at home.
• The +0.5 line has been covered by Anderlecht in 16 of their last 20 games at home.
• The +0.5 line has been covered by Anderlecht in 7 of their last 10 games.
• The -0.5 line hasn’t been covered by OL in 7 of their last 10 games on the road.
• The -0.5 line hasn’t been covered by OL in 13 of their last 20 games on the road.

We always have a keen eye on team news, while our football experts have their finger on the pulse by knowing the latest form. You will also find a compendium of stats which provide some valuable pointers ahead of the Europa League action.

The top betting apps make it a 54.6% chance that our pick is settled as a winner. After careful examination, our tipsters have this probability close to 60%. It is therefore regarded as a value wager.

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 14, 21:28). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Anderlecht 1 - 1 Lyon

Our prediction is a 1-1 draw which is available at odds of +525. Correct score betting allows us to bet at bigger odds and it’s also a fun type of wager.

Player Prop Picks

Top Pick: Corentin Tolisso Over 0.5 Shots On Target -137

Corentin Tolisso (OL) has tallied one or more shots on goal in six of his past nine games. We recommend backing the -137 that he is able to cover the line, with this Shots on Target wager hopefully providing a return.

Latest Corentin Tolisso Player Prop Odds

Goalscorer

Anytime

+240

First

+700

Shots On Target

Over 0.5

-137

Under 0.5

-

---

Danylo Sikan to Score +250

Danylo Sikan (Anderlecht) has netted three goals in his past five home matches. We’ll take a chance at +250 for this Anytime Goalscorer wager as the betting odds look really appealing.

Latest Danylo Sikan Player Prop Odds

Goalscorer

Anytime

+250

First

+700

Shots On Target

Over 0.5

-139

Under 0.5

-

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Corners Prediction

Over 9.5 Corners -114

There’s been a corner average of 14.00 in the past five games involving Lyon, with the previous ten Anderlecht home matches averaging 10.40. We’re going to take the Overs for Total Corners, with this line making appeal and you can get odds of -114.

Europa League & League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Anderlecht

Total

9.30 5.40 3.90

Home

10.40 6.40 4.00

Away

9.70 4.10 5.60

Lyon

Total

13.40 7.20 6.20

Home

12.10 7.00 5.10

Away

9.60 4.40 5.20

Latest Corner Odds

Total Corners

Over 9.5

-109

Under 9.5

-132

Anderlecht Corners

Over 4.5

+102

Under 4.5

-147

Lyon Corners

Over 4.5

-133

Under 4.5

-109

Most Corners

1

+123

X

+600

2

-119

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Anderlecht vs Lyon Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Some will want to go ahead and back Lyon at -103 to win this Europa League encounter. After all, this betting price suggests a 51% chance that the favourites end up succeeding. Anderlecht are the +250 underdogs, while the draw can also be backed as an alternative.

Lyon and Anderlecht can be backed at -222 and +150 respectively on the Draw No Bet market. This is an ideal route for bettors who want to ensure they have money back if the scoreline ends level.

The Total Goals market indicates that Over 2.5 Goals is the betting favourite right now. Punters expecting both teams to find the net can get -189 when it comes to BTTS Yes.

For those wanting hundreds of football markets, it’s great that the top betting sites are on hand to offer this service. When it comes to every Europa League game, go for the pick which stands out the most.

Full-Time Result

1

+250

X

+275

2

-103

Half-Time Result

1

+270

X

+138

2

+148

Double Chance

1X

-123

12

-385

X2

-345

Draw No Bet

1

+150

2

-222

Asian Handicap

1 Hcp +0.5

-120

2 Hcp -0.5

-109

Total Goals

Under 2.5

+128

Over 2.5

-164

Both Teams to Score

Yes

-189

No

+135

Loïs Openda is favourite to be First Goalscorer at +400 and if you’re keen to back him to simply find the net, then the price is +135.

Loïs Openda (OL)

First

+400

Anytime

+135

Rémi Stéphane Himbert (OL)

First

+480

Anytime

+170

Pavel Sulc (OL)

First

+550

Anytime

+190

Corentin Tolisso (OL)

First

+700

Anytime

+240

Adriano Bertaccini (Anderlecht)

First

+700

Anytime

+250

Danylo Sikan (Anderlecht)

First

+700

Anytime

+250

Julien Duranville (OL)

First

+700

Anytime

+250

Mihajlo Cvetkovic (Anderlecht)

First

+750

Anytime

+250

Ernest Nuamah (OL)

First

+700

Anytime

+260

Kail Boudache (OL)

First

+800

Anytime

+290

Lukas Ambros (Anderlecht)

First

+850

Anytime

+300

Marten Winkler (Anderlecht)

First

+950

Anytime

+340

Noah Nartey (OL)

First

+1050

Anytime

+360

Oliver Antman (Anderlecht)

First

+1050

Anytime

+390

Tristan Degreef (Anderlecht)

First

+1150

Anytime

+420

Mario Stroeykens (Anderlecht)

First

+1400

Anytime

+480

Mohamed Ouédraogo (OL)

First

+1500

Anytime

+500

Mads Bidstrup (OL)

First

+1400

Anytime

+525

Khalis Merah (OL)

First

+1600

Anytime

+550

Abner Vinicius da Silva Santos (OL)

First

+1600

Anytime

+550

Enric Llansana (Anderlecht)

First

+1500

Anytime

+600

Tyler Morton (OL)

First

+1700

Anytime

+600

Tanner Tessmann (OL)

First

+1900

Anytime

+700

Felix Bacher (OL)

First

+2000

Anytime

+750

Moussa Niakhaté (OL)

First

+2200

Anytime

+800

Rémi Stéphane Himbert (OL)

Over 0.5

-192

Under 0.5

-

Pavel Sulc (OL)

Over 0.5

-182

Under 0.5

-

Adriano Bertaccini (Anderlecht)

Over 0.5

-143

Under 0.5

-

Danylo Sikan (Anderlecht)

Over 0.5

-139

Under 0.5

-

Ernest Nuamah (OL)

Over 0.5

-139

Under 0.5

-

Corentin Tolisso (OL)

Over 0.5

-137

Under 0.5

-

Julien Duranville (OL)

Over 0.5

-128

Under 0.5

-

Mihajlo Cvetkovic (Anderlecht)

Over 0.5

-125

Under 0.5

-

Lukas Ambros (Anderlecht)

Over 0.5

-108

Under 0.5

-

Kail Boudache (OL)

Over 0.5

-104

Under 0.5

-

Marten Winkler (Anderlecht)

Over 0.5

+110

Under 0.5

-

Oliver Antman (Anderlecht)

Over 0.5

+128

Under 0.5

-

Noah Nartey (OL)

Over 0.5

+135

Under 0.5

-

Loïs Openda (OL)

Over 1.5

+145

Under 1.5

-

Tristan Degreef (Anderlecht)

Over 0.5

+145

Under 0.5

-

Mario Stroeykens (Anderlecht)

Over 0.5

+165

Under 0.5

-

Mohamed Ouédraogo (OL)

Over 0.5

+185

Under 0.5

-

Mads Bidstrup (OL)

Over 0.5

+195

Under 0.5

-

Khalis Merah (OL)

Over 0.5

+210

Under 0.5

-

Abner Vinicius da Silva Santos (OL)

Over 0.5

+220

Under 0.5

-

Enric Llansana (Anderlecht)

Over 0.5

+220

Under 0.5

-

Tyler Morton (OL)

Over 0.5

+230

Under 0.5

-

Tanner Tessmann (OL)

Over 0.5

+280

Under 0.5

-

Felix Bacher (OL)

Over 0.5

+290

Under 0.5

-

Moussa Niakhaté (OL)

Over 0.5

+330

Under 0.5

-

Latest Europa League and domestic league stats. Full Time Result, Goals, Corners and Possession.

Anderlecht Stats

Lyon Stats

Full-Time Result

• 4 wins, 3 defeats and 3 draws in the previous 10 matches
• 5 wins, 3 defeats and 2 draws in the previous 10 home matches

Full-Time Result

• 6 wins, 2 defeats and 2 draws in the previous 10 matches
• 3 wins, 3 defeats and 4 draws in the previous 10 away matches

Goals

• An average of 1.10 goals scored and 1.40 conceded in the previous 10 matches
• An average of 2.00 goals scored and 1.50 conceded in the previous 10 home matches
• An average of 2.50 goals per game in the previous 10 matches
• An average of 3.50 goals per game in the previous 10 home matches
• BTTS Yes in 5 of the previous 10 matches
• BTTS Yes in 8 of the previous 10 home matches
• Over 2.5 Goals in 5 of the previous 10 matches
• Over 2.5 Goals in 8 of the previous 10 home matches

Goals

• An average of 1.80 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.00 goals scored and 1.00 conceded in the previous 10 away matches
• An average of 3.10 goals per game in the previous 10 matches
• An average of 2.00 goals per game in the previous 10 away matches
• BTTS Yes in 6 of the previous 10 matches
• BTTS Yes in 5 of the previous 10 away matches
• Over 2.5 Goals in 6 of the previous 10 matches
• Over 2.5 Goals in 4 of the previous 10 away matches

Corners

• An average of 5.40 corners awarded and 3.90 corners conceded in the last 10 matches
• An average of 6.40 corners awarded and 4.00 corners against in the last 10 home matches
• An average of 9.30 corners awarded in the last 10 matches
• An average of 10.40 corners awarded in the last 10 home matches
• Had the most corners in 4 and least corners in 5 of the last 10 matches
• Had the most corners in 7 and least corners in 1 of the last 10 home matches

Corners

• An average of 7.20 corners awarded and 6.20 corners conceded in the last 10 matches
• An average of 4.40 corners awarded and 5.20 corners against in the last 10 away matches
• An average of 13.40 corners awarded in the last 10 matches
• An average of 9.60 corners awarded in the last 10 away matches
• Had the most corners in 5 and least corners in 4 of the last 10 matches
• Had the most corners in 3 and least corners in 6 of the last 10 away matches

Possession

• An average of 53.30% possession in the last 10 matches
• An average of 59.10% possession in the last 10 home matches
• Most possession in 7 of the last 10 matches
• Most possession in 9 of the last 10 home matches

Possession

• An average of 51.30% possession in the last 10 matches
• An average of 52.50% possession in the last 10 away matches
• Most possession in 7 of the last 10 matches
• Most possession in 5 of the last 10 away matches

Anderlecht vs Lyon Lineups & Team News

Before placing any bets on Anderlecht vs OL, check the team news first. Receive the predicted and confirmed Europa League lineups from us, plus the most recent injury updates.

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