Manchester City vs Southampton Prediction, Betting Tips, Lineups & Odds | 25 Apr 2026

FA Cup Semi-Final Betting Preview: Manchester City vs Southampton

Premier League leaders Manchester City host Championship club Southampton in this FA Cup semi-final at Wembley, with kick-off set for 12:15 on Saturday 25 April.

We’re leaning towards Southampton +2 on the Asian Handicap at -118, with Manchester City not expected to run away with it. Our stake is refunded if the Saints lose by exactly two goals.

Both teams come into this semi-final in top form, with City unbeaten in 16 games and Southampton in 20.

City won their last game 1-0, beating Burnley away at Turf Moor to go top of the Premier League, ahead of Arsenal on goals scored. Pep Guardiola's team recorded nine shots on target and boasted 65% possession, with Erling Haaland netting the winner early in the first half.

Southampton, in the play-off places in the Championship, played out a 2-2 draw at home to Bristol City at St Mary’s in their previous Championship match. The South Coast outfit had four shots on goal and enjoyed 54% possession, with Cyle Larin and Ross Stewart on the scoresheet.

In the FA Cup quarter-finals, City were at home to Liverpool and won 4-0, while Southampton hosted Arsenal and landed a 2-1 victory.

Head-to-Head Statistics

City haven’t lost to Southampton in their past nine games, with the last clash ending in a 0-0 Premier League draw at St. Mary's. The previous 10 H2H matches have ended up with six City wins, one Southampton victory and three draws.

Premier League		G	W	D	L	GF	GA	GD	GD	P
2	Man City	38	23	9	6	77	35	42	77:35	78

Championship		G	W	D	L	GF	GA	GD	GD	P
4	Southampton	46	22	14	10	82	56	26	82:56	80

8 wins and 2 draws, averaging 2.1 goals from 18.5 attempts and 6.4 shots on goal. City have had 64.4% possession and 8.0 corners per match. On average, the opposition have scored 0.6 goals from 9.6 attempts and 3.3 shots on goal, while earning 3.5 corners.

Erling Haaland is the top scorer with 5 goals, while Nico O'Reilly and Antoine Semenyo each have 3. Rayan Cherki has the most assists with 4, while goalkeepers Gianluigi Donnarumma and James Trafford have recorded 5 clean sheets between them.

Southampton have won 8 and drawn 2, with an average of 2.2 goals from 11.8 attempts and 5.2 shots on goal. There’s been an average of 53.7% possession, 5.9 corners awarded and 4.6 corners against them, while they’ve conceded 0.8 goals from 11.5 attempts and 4.3 shots on goal.

Cyle Larin is top of the team’s scoring charts with 5, while Ross Stewart and Shea Charles both have 3. Look no further than Tom Fellows for the top assist maker (3) in the last 10 games.

Confirmed Lineups

Manchester City confirmed lineup (4-2-3-1): James Trafford (GK), Matheus Nunes, John Stones, Nathan Ake, Rayan Ait Nouri, Nico Gonzalez, Mateo Kovacic, Rayan Cherki, Tijjani Reijnders, Phil Foden, Omar Marmoush.

Southampton confirmed lineup (3-2-4-1): Daniel Peretz (GK), James Bree, Taylor Harwood-Bellis, Nathan Wood, Tom Fellows, Welington, Finn Azaz, Cameron Bragg, Caspar Jander, Leo Scienza, Ross Stewart.

Manchester City vs Southampton Prediction & Betting Tips

The Manchester City vs Southampton betting tips feature sharp analysis across major markets, including a key match prediction, player prop bets, correct score guidance and a ready-made bet builder.

Match Prediction

Betting on Southampton +2 at -118 could be a sensible play when it comes to this FA Cup semi-final. We expect the Championship side to keep the scoreline relatively close which makes this a value pick.

The first step involves analysing the form and also getting an idea of the injury situation before making any football picks. Then it’s a case of consulting the latest FA Cup stats and seeing if they can inform our opinion.

Key Manchester City vs Southampton FA Cup & league stats:

• The +2 line has been covered by Southampton in 20 consecutive games.
• The -2 line hasn’t been covered by City in 8 of their last 10 games.
• The -2 line hasn’t been covered by City in 16 of their last 20 games.
• The -2 line hasn’t been covered by City in 2 consecutive games.
• The -2 line hasn’t been covered by City in 2 consecutive games against Southampton.

The betting apps are estimating that there is a 54.1% likelihood of this pick landing a return. Based on our experts research, we calculate the actual probability to be closer to 60%. This is why we can recommend this wager.

In the quest to secure larger odds, there’s the possibility of moving the line. There are plenty of choices when it comes to doing this, so you can choose the option that suits you.

Make your bet go further. Browse our updated guide packed with the best free bets, sign-up offers and betting bonuses.

Our Match Prediction

Southampton Asian Hcp +2 @ -118 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Apr 23, 18:28). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Man City 2 - 1 Southampton

The Citizens can be backed to win 2-1 when it comes to the correct score. We’ll go for the +750 that this happens and hopefully we’ll get a good run for our money.

Player Prop Picks

Top Pick: Nico O'Reilly Over 1.5 Shots -147

Nico O'Reilly (City) has managed an average of 1.6 shots in his past five matches. Out of the prop bets currently on offer, we’re opting for the -147 when it comes to this Player Shots wager.

Latest Nico O'Reilly Player Prop Odds

Goalscorer

Anytime

+290

First

+900

Shots

Over 1.5

-213

Under 1.5

-

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Jérémy Doku To Score +330

Jérémy Doku (City) can be backed to find the net at +330. He looks like a value bet to find the net and we recommend backing this Anytime Goalscorer pick.

Latest Jérémy Doku Player Prop Odds

Goalscorer

Anytime

+340

First

+1100

Shots

Over 1.5

-130

Under 1.5

-

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Manchester City vs Southampton Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The latest Full-Time Result odds give Manchester City a 81% chance of triumphing which means that they’re overwhelming -435 favourites to win this FA Cup semi-final. If you want to back the outsider, Southampton are available at +1000.

Should you want to back City to lead at the break, then there is -172 available on the Half-Time Result market. Opponents Southampton have been chalked up at +650 and the draw is +200.

The Over 2.5 option is currently favourite on the Total Goals betting market. Both Teams to Score is a two-way market and, in terms of price, there’s not much to split Yes and No.

The recommended football betting sites will provide a first-class service and that includes getting hundreds of markets. Scan through them for any FA Cup match and take your pick.

Full-Time Result

1

-435

X

+540

2

+1000

Half-Time Result

1

-172

X

+200

2

+650

Double Chance

1X

-3333

12

-909

X2

+300

Draw No Bet

1

-2000

2

+700

Asian Handicap

1 Hcp -1.75

-125

2 Hcp +1.75

-100

Total Goals

Under 2.5

+188

Over 2.5

-250

Both Teams to Score

Yes

-119

No

-116

Erling Haaland is the market leader at +205 to be First Goalscorer but if you think he will score the last goal, then a similar price can be found.

Erling Haaland (City)

First

-200

Anytime

+205

Antoine Semenyo (City)

First

+130

Anytime

+400

Omar Marmoush (City)

First

+130

Anytime

+400

Phil Foden (City)

First

+160

Anytime

+550

Rayan Cherki (City)

First

+230

Anytime

+700

Tijjani Reijnders (City)

First

+250

Anytime

+800

Sávio de Oliveira (City)

First

+260

Anytime

+800

Nico O'Reilly (City)

First

+290

Anytime

+900

Jérémy Doku (City)

First

+340

Anytime

+1100

Leo Scienza (Southampton)

First

+400

Anytime

+1200

Cyle Larin (Southampton)

First

+450

Anytime

+1400

Bernardo Silva (City)

First

+450

Anytime

+1400

Ross Cameron Stewart (Southampton)

First

+480

Anytime

+1500

Finn Azaz (Southampton)

First

+480

Anytime

+1500

Cameron Archer (Southampton)

First

+500

Anytime

+1600

Nico Gonzalez (City)

First

+550

Anytime

+1700

Ruben Dias (City)

First

+650

Anytime

+1900

Rodri (City)

First

+650

Anytime

+2000

Josko Gvardiol (City)

First

+650

Anytime

+2200

Abdukodir Khusanov (City)

First

+700

Anytime

+2000

Rico Lewis (City)

First

+700

Anytime

+2200

John Stones (City)

First

+700

Anytime

+2200

Nathan Aké (City)

First

+700

Anytime

+2200

Rayan Aït Nouri (City)

First

+700

Anytime

+2200

Marc Guéhi (City)

First

+700

Anytime

+2200

Matheus Nunes (City)

First

+700

Anytime

+2200

Max Alleyne (City)

First

+700

Anytime

+2200

Erling Haaland (City)

Over 5.5

+117

Under 5.5

-

Omar Marmoush (City)

Over 3.5

+102

Under 3.5

-

Antoine Semenyo (City)

Over 3.5

-100

Under 3.5

-

Phil Foden (City)

Over 2.5

-127

Under 2.5

-

Rayan Cherki (City)

Over 2.5

+120

Under 2.5

-

Cyle Larin (Southampton)

Over 1.5

+114

Under 1.5

-

Cameron Archer (Southampton)

Over 1.5

+150

Under 1.5

-

Ross Cameron Stewart (Southampton)

Over 1.5

+130

Under 1.5

-

Finn Azaz (Southampton)

Over 1.5

+135

Under 1.5

-

Leo Scienza (Southampton)

Over 1.5

-102

Under 1.5

-

Nico O'Reilly (City)

Over 1.5

-213

Under 1.5

-

Sávio de Oliveira (City)

Over 1.5

-147

Under 1.5

-

Tijjani Reijnders (City)

Over 1.5

-152

Under 1.5

-

Jérémy Doku (City)

Over 1.5

-130

Under 1.5

-

John Stones (City)

Over 0.5

+110

Under 0.5

-

Matheus Nunes (City)

Over 0.5

+118

Under 0.5

-

Marc Guéhi (City)

Over 0.5

-108

Under 0.5

-

Rayan Aït Nouri (City)

Over 0.5

+102

Under 0.5

-

Nathan Aké (City)

Over 0.5

+114

Under 0.5

-

Josko Gvardiol (City)

Over 0.5

+102

Under 0.5

-

Rico Lewis (City)

Over 0.5

+114

Under 0.5

-

Abdukodir Khusanov (City)

Over 0.5

+114

Under 0.5

-

Rodri (City)

Over 0.5

-133

Under 0.5

-

Ruben Dias (City)

Over 0.5

+104

Under 0.5

-

Nico Gonzalez (City)

Over 0.5

-250

Under 0.5

-

Bernardo Silva (City)

Over 0.5

-244

Under 0.5

-

Max Alleyne (City)

Over 0.5

+110

Under 0.5

-

Latest FA Cup and domestic league stats. Full Time Result, Goals, Corners and Possession.

Manchester City Stats

Southampton Stats

Full-Time Result

• 8 wins and 2 draws in the previous 10 matches
• 7 wins and 3 draws in the previous 10 home matches

Full-Time Result

• 8 wins and 2 draws in the previous 10 matches
• 8 wins and 2 draws in the previous 10 away matches

Goals

• An average of 2.10 goals scored and 0.60 conceded in the previous 10 matches
• An average of 2.90 goals scored and 0.70 conceded in the previous 10 home matches
• An average of 2.70 goals per game in the previous 10 matches
• An average of 3.60 goals per game in the previous 10 home matches
• BTTS Yes in 5 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 home matches
• Over 2.5 Goals in 6 of the previous 10 matches
• Over 2.5 Goals in 6 of the previous 10 home matches

Goals

• An average of 2.20 goals scored and 0.80 conceded in the previous 10 matches
• An average of 2.40 goals scored and 1.10 conceded in the previous 10 away matches
• An average of 3.00 goals per game in the previous 10 matches
• An average of 3.50 goals per game in the previous 10 away matches
• BTTS Yes in 7 of the previous 10 matches
• BTTS Yes in 8 of the previous 10 away matches
• Over 2.5 Goals in 7 of the previous 10 matches
• Over 2.5 Goals in 6 of the previous 10 away matches

Corners

• An average of 8.00 corners awarded and 3.50 corners conceded in the last 10 matches
• An average of 5.78 corners awarded and 3.67 corners against in the last 9 home matches
• An average of 11.50 corners awarded in the last 10 matches
• An average of 9.44 corners awarded in the last 9 home matches
• Had the most corners in 8 and least corners in 1 of the last 10 matches
• Had the most corners in 6 and least corners in 1 of the last 9 home matches

Corners

• An average of 5.90 corners awarded and 4.60 corners conceded in the last 10 matches
• An average of 5.78 corners awarded and 5.56 corners against in the last 9 away matches
• An average of 10.50 corners awarded in the last 10 matches
• An average of 11.33 corners awarded in the last 9 away matches
• Had the most corners in 6 and least corners in 3 of the last 10 matches
• Had the most corners in 5 and least corners in 4 of the last 9 away matches

Possession

• An average of 64.40% possession in the last 10 matches
• An average of 61.22% possession in the last 9 home matches
• Most possession in 9 of the last 10 matches
• Most possession in 8 of the last 9 home matches

Possession

• An average of 53.70% possession in the last 10 matches
• An average of 50.89% possession in the last 9 away matches
• Most possession in 6 of the last 10 matches
• Most possession in 4 of the last 9 away matches

Manchester City vs Southampton Lineups & Team News

Before making your bets, take a look at the City vs Southampton team news. Expect the predicted and confirmed FA Cup lineups along with timely injury updates.

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