San Lorenzo vs Santos Prediction, Betting Tips, Lineups & Odds | 28 Apr 2026

Copa Sudamericana Betting Preview: San Lorenzo vs Santos

Argentine Primera División team San Lorenzo host Brazilian Série A side Santos, with kick-off set for 18:00 on Tuesday 28 April.

We will split our stake on the Asian Handicap between 0 and +0.5 when wagering Santos +0.25 at -118 against San Lorenzo. We need a victory for a full payout although the draw means a return is on the cards.

San Lorenzo won last time out by a 1-0 scoreline. It was away from home against Platense in the Primera División. El Ciclón managed six shots on target and had 44% possession, with Rodrigo Auzmendi scoring the winning goal in the 27th minute.

Santos drew 2-2 in their previous game. This took place on the road against Bahia in Série A. Cuca's team had just 36% possession and totalled six shots on goal, with Benjamin Rollheiser netting twice.

In the last Copa Sudamericana round, San Lorenzo hosted Deportivo Cuenca and won 2-0, while Santos were held to a 1-1 draw at home to Recoleta.

Copa Sudamericana		G	W	D	L	GF	GA	GD	GD	P
2	Santos	6	1	4	1	8	6	2	8:6	7
3	San Lorenzo	6	1	4	1	6	5	1	6:5	7

View Full Table

Confirmed Lineups

San Lorenzo confirmed lineup (3-4-2-1): Orlando Gill (GK), Ezequiel Herrera, Jhohan Romana, Lautaro Montenegro, Nicolas Tripichio, Facundo Gulli, Manuel Insaurralde, Mathias De Ritis, Alexis Cuello, Matias Reali, Rodrigo Auzmendi.

Santos confirmed lineup (4-2-3-1): Gabriel Brazao (GK), Mayke, Lucas Verissimo, Luan Peres, Gonzalo Escobar, Willian Arao, Christian Oliva, Gabriel Bontempo, Benjamin Rollheiser, Neymar, Gabriel Barbosa.

San Lorenzo vs Santos Prediction & Betting Tips

Step into San Lorenzo vs Santos with confidence as we bring you our expert match prediction, projected scoreline, best player prop picks and a custom-built bet builder.

Match Prediction

If you echo our view that Santos can swerve defeat in this Copa Sudamericana encounter, then you can take them with a +0.25 goal start at -118. There are strong reasons to back the visitors.

Team news is very useful and our football tipsters are keen to identify the players who are doubtful with injury. You’ll also find us studying the form guide, with lots of Copa Sudamericana data available which provides a clear picture from the stats.

Key San Lorenzo vs Santos Copa Sudamericana & league stats:

• The +0.25 line has been covered by Santos in 14 of their last 20 games.
• The +0.25 line has been covered by Santos in 6 of their last 10 games.
• The -0.25 line hasn’t been covered by San Lorenzo in 7 of their last 10 games.
• The -0.25 line hasn’t been covered by San Lorenzo in 14 of their last 20 games.

The latest odds imply that our pick has a 54.1% prospect of winning. However, our tipsters have this number closer to 60% based on their in-depth research. It’s the reason why we are recommending this bet.

The bookmakers give you the chance to buy or sell goals, meaning that you can select from a variety of lines. Buying means shorter prices, with selling sending the odds upwards.

Ready to wager? First, explore top-tier betting promo codes, free bets, and welcome bonuses with our expert bonus guide.

Our Match Prediction

Santos Asian Hcp +0.25 @ -118 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Apr 27, 00:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

San Lorenzo 0 - 1 Santos

We’re going for Santos at +525 to secure a 1-0 win. It’s exciting to bet on the correct score and this wager will hopefully be able to land a nice return.

Player Prop Picks

Top Pick: Neymar to Score +270

Neymar (Santos) has registered two goals in his past six games. He looks like an attractive wager to be on the scoresheet and you’re able to back this Anytime Goalscorer selection at odds of +270.

Latest Neymar Player Prop Odds

Goalscorer

Anytime

+250

First

+500

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

San Lorenzo vs Santos Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

San Lorenzo are +163 with the bookies to get the better of Santos, with the latter having betting odds of +235. If you want to back the draw to be landed in this Copa Sudamericana encounter, this can be wagered at +160.

There’s sometimes a case for betting on the Draw No Bet market, with San Lorenzo available at -154 for those who want insurance on their bet. The same applies to opponents Santos at +108.

If you think there will be two goals or less during the ninety minutes, then Under 2.5 Goals is a potential option. An alternative approach is playing the BTTS market and going for the -159 about Both Teams to Score No.

Hundreds of markets are now a guarantee for each of the Copa Sudamericana matches, with the recommended football betting sites making sure that customers have quality options.

Full-Time Result

1

+163

X

+160

2

+235

Half-Time Result

1

+230

X

-119

2

+295

Double Chance

1X

-333

12

-222

X2

-222

Draw No Bet

1

-154

2

+108

Asian Handicap

1 Hcp -0.25

+112

2 Hcp +0.25

-147

Total Goals

Under 2.5

-270

Over 2.5

+190

Both Teams to Score

Yes

+115

No

-159

Those interested in favourite Alexis Cuello to find the net first are able to get +400. If the Anytime Goalscorer angle makes more appeal, then this is +190.

Alexis Cuello (San Lorenzo)

First

+190

Anytime

+400

Luciano Vietto (San Lorenzo)

First

+230

Anytime

+480

Neymar (Santos)

First

+250

Anytime

+500

Gabigol (Santos)

First

+300

Anytime

+650

Rodrigo Auzmendi (San Lorenzo)

First

+350

Anytime

+750

Matías Reali (San Lorenzo)

First

+420

Anytime

+900

Ronielson Rony (Santos)

First

+420

Anytime

+900

Diego Herazo (San Lorenzo)

First

+430

Anytime

+950

Lautaro Díaz (Santos)

First

+475

Anytime

+1050

Álvaro Barreal (Santos)

First

+550

Anytime

+1200

Miguel Terceros (Santos)

First

+650

Anytime

+1400

Francisco Perruzzi (San Lorenzo)

First

+650

Anytime

+1400

Thaciano Mickael Silva (Santos)

First

+700

Anytime

+1500

Christian Oliva (Santos)

First

+700

Anytime

+1600

Benjamín Rollheiser (Santos)

First

+700

Anytime

+1600

Ezequiel Cerutti (San Lorenzo)

First

+800

Anytime

+1700

Gonzalo Abrego (San Lorenzo)

First

+800

Anytime

+1900

Mauricio Cardillo (San Lorenzo)

First

+850

Anytime

+1900

Gabriel Menino (Santos)

First

+900

Anytime

+2200

Gabriel Bontempo (Santos)

First

+950

Anytime

+2000

Ignacio Perruzzi Ambrosini (San Lorenzo)

First

+950

Anytime

+2000

Nicolás Tripichio (San Lorenzo)

First

+950

Anytime

+2200

Latest Copa Sudamericana and domestic league stats. Full Time Result, Goals, Corners and Possession.

San Lorenzo Stats

Santos Stats

Full-Time Result

• 3 wins, 1 defeat and 6 draws in the previous 10 matches
• 5 wins, 2 defeats and 3 draws in the previous 10 home matches

Full-Time Result

• 2 wins, 4 defeats and 4 draws in the previous 10 matches
• 1 win, 5 defeats and 4 draws in the previous 10 away matches

Goals

• An average of 0.90 goals scored and 0.80 conceded in the previous 10 matches
• An average of 1.30 goals scored and 1.00 conceded in the previous 10 home matches
• An average of 1.70 goals per game in the previous 10 matches
• An average of 2.30 goals per game in the previous 10 home matches
• BTTS Yes in 4 of the previous 10 matches
• BTTS Yes in 4 of the previous 10 home matches
• Over 2.5 Goals in 1 of the previous 10 matches
• Over 2.5 Goals in 2 of the previous 10 home matches

Goals

• An average of 1.10 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.40 goals scored and 1.80 conceded in the previous 10 away matches
• An average of 2.40 goals per game in the previous 10 matches
• An average of 3.20 goals per game in the previous 10 away matches
• BTTS Yes in 6 of the previous 10 matches
• BTTS Yes in 7 of the previous 10 away matches
• Over 2.5 Goals in 4 of the previous 10 matches
• Over 2.5 Goals in 7 of the previous 10 away matches

Corners

• An average of 4.25 corners awarded and 4.00 corners conceded in the last 8 matches
• An average of 4.00 corners awarded and 4.67 corners against in the last 9 home matches
• An average of 8.25 corners awarded in the last 8 matches
• An average of 8.67 corners awarded in the last 9 home matches
• Had the most corners in 5 and least corners in 3 of the last 8 matches
• Had the most corners in 4 and least corners in 5 of the last 9 home matches

Corners

• An average of 4.38 corners awarded and 5.25 corners conceded in the last 8 matches
• An average of 4.33 corners awarded and 5.44 corners against in the last 9 away matches
• An average of 9.63 corners awarded in the last 8 matches
• An average of 9.78 corners awarded in the last 9 away matches
• Had the most corners in 3 and least corners in 5 of the last 8 matches
• Had the most corners in 3 and least corners in 6 of the last 9 away matches

Possession

• An average of 49.00% possession in the last 8 matches
• An average of 52.56% possession in the last 9 home matches
• Most possession in 4 of the last 8 matches
• Most possession in 6 of the last 9 home matches

Possession

• An average of 46.38% possession in the last 8 matches
• An average of 44.11% possession in the last 9 away matches
• Most possession in 2 of the last 8 matches
• Most possession in 1 of the last 9 away matches

San Lorenzo vs Santos Lineups & Team News

Check the San Lorenzo vs Santos team news before you place your bets. Get the latest predicted and confirmed Copa Sudamericana lineups and injury news right here.

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