Santa Fe vs América de Cali Prediction, Betting Tips & Odds | 12 May 2026

Primera A Betting Preview: Santa Fe vs América de Cali

Santa Fe go head-to-head with América de Cali, with kick-off set for 21:30 on Tuesday 12 May.

If you agree with our verdict that Santa Fe can defeat América de Cali, then there’s the chance to get betting odds of +114 that this happens. We think that this price sticks out on the Full-Time Result market.

Most Recent H2H Clash Ended 1-1

Santa Fe visited América de Cali on Saturday night, with the game ending in a 1-1 draw. Adrian Ramos found the net for América, with Hugo Rodallega on the scoresheet for Santa Fe.

The past 10 clashes on the H2H have resulted in four draws, and three wins apiece for each team.

Categoria Primera A		G	W	D	L	GF	GA	GD	GD	P
4	América de Cali	19	10	3	6	25	15	10	25:15	33
7	Santa Fe	19	7	8	4	29	22	7	29:22	29

View Full Table

Santa Fe vs América de Cali Prediction & Betting Tips

Join us as we dissect the top Santa Fe vs América de Cali betting picks — from the main match prediction and scoreline forecast to standout player props and a value-focused bet builder.

Match Prediction

Our opinion is that Santa Fe will prove too strong for their opponents and we’ll therefore take the +114 for this Primera A game. This bet really stands out when it comes to securing value.

The latest injuries and suspensions can affect the overall outcome and we use this information as well as the form guide. The same applies to the stats so that we can get the best understanding of how things might pan out.

Key Santa Fe vs América de Cali league stats:

• Santa Fe have won 3 of their last 5 games at home.
• Santa Fe have won 2 consecutive games at home.
• América have lost 6 of their last 10 games on the road.
• América have lost 12 of their last 20 games on the road.

The odds at the best football bookies suggest our pick has a 46.7% chance of winning. Based on our tipsters research, we calculate the actual probability to be 50-55%. This is why we regard this as a value bet.

For those bettors who want to boost their odds for Santa Fe to secure a victory, why not combine this pick with some of the other available options in a Bet Builder.

Give your betting journey a head start. Explore the latest welcome offers and free bets in our easy-to-follow guide.

Our Match Prediction

Santa Fe To Win @ +114 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (May 11, 03:57). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santa Fe 2 - 1 América

We’ve got a correct score prediction which involves Santa Fe winning 2-1. Odds of +600 look appealing and we should get a run for our money here.

Player Prop Picks

Top Pick: Omar Fernandez To Score +200

Omar Fernandez (Santa Fe) can be wagered to be on the scoresheet at +200. We believe that there is merit in backing him for an Anytime Goalscorer prop wager which means we need him to be on the scoresheet.

Latest Omar Fernandez Player Prop Odds

Goalscorer

Anytime

+210

First

+450

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santa Fe vs América de Cali Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The favourites are 47% likely to win according to the latest betting odds, with Santa Fe being priced at +114 to come away with a victory in this Primera A encounter. For those wanting to oppose the market leader, you can get +225 about América de Cali.

If you want to side with Santa Fe winning against América, then the -0.25 on the Asian Handicap is one potential option. You can land -122 and also have the insurance of half stake returns in the event of a draw.

The Total Goals odds suggest that Under 2.5 is the likelier outcome in this contest. For those wanting to bet on Both Teams to Score, you won’t find much between Yes and No.

For those visiting the best betting sites, you are guaranteed a fantastic service for all the Primera A games. The hundreds of football markets always ensure lots of choice.

Full-Time Result

1

+114

X

+220

2

+225

Half-Time Result

1

+175

X

+107

2

+275

Double Chance

1X

-357

12

-345

X2

-167

Draw No Bet

1

-185

2

+128

Asian Handicap

1 Hcp -0.25

-122

2 Hcp +0.25

-118

Total Goals

Under 2.5

-159

Over 2.5

+110

Both Teams to Score

Yes

-116

No

-122

Favourite Hugo Rodallega is available at +300 to be the First Goalscorer. Similar odds apply if you’re interested in him to score the last goal.

Hugo Rodallega (Santa Fe)

First

+140

Anytime

+300

Omar Fernandez (Santa Fe)

First

+210

Anytime

+450

Franco Fagúndez (Santa Fe)

First

+250

Anytime

+550

Jorge Ramos (Santa Fe)

First

+265

Anytime

+575

Jorge Daniel Valencia (América)

First

+275

Anytime

+600

Nahuel Bustos (Santa Fe)

First

+295

Anytime

+600

Yeison Guzmán (América)

First

+310

Anytime

+650

Adrián Ramos (América)

First

+350

Anytime

+750

Jáder Obrian (Santa Fe)

First

+360

Anytime

+800

Darwin Machís (América)

First

+400

Anytime

+850

Luis Angel Palacios (Santa Fe)

First

+400

Anytime

+850

Edwin Mosquera (Santa Fe)

First

+410

Anytime

+850

Alexis Zapata (Santa Fe)

First

+410

Anytime

+850

Joel Romero (América)

First

+430

Anytime

+900

Tomás Ángel (América)

First

+440

Anytime

+900

Yojan Garcés (América)

First

+460

Anytime

+1050

Maximiliano Lovera (Santa Fe)

First

+480

Anytime

+1000

Jan Lucumí (América)

First

+510

Anytime

+1100

Tilman Palacios (América)

First

+525

Anytime

+1100

Dylan Borrero (América)

First

+525

Anytime

+1150

Christian Mafla (Santa Fe)

First

+600

Anytime

+1200

Yilmar Andres Velasquez (Santa Fe)

First

+600

Anytime

+1200

Carlos Sierra (América)

First

+650

Anytime

+1500

Rafael Carrascal (América)

First

+700

Anytime

+1600

Josen Escobar (América)

First

+750

Anytime

+1600

Mateo Castillo (América)

First

+800

Anytime

+1700

Ewil Murillo (Santa Fe)

First

+850

Anytime

+1800

Kilian Toscano (Santa Fe)

First

+850

Anytime

+1800

Iván Scarpeta (Santa Fe)

First

+850

Anytime

+1900

Victor Moreno (Santa Fe)

First

+900

Anytime

+2000

Santa Fe vs América de Cali Lineups & Team News

Be smart with your bets — check the Santa Fe vs América team news beforehand. We’ll provide the latest confirmed Primera A lineups along with injury updates.

Santa Fe Team Page América de Cali Team Page

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