Santa Fe vs Deportivo Cali Prediction, Betting Tips & Odds | 22 Sep 2026

Santa Fe vs Deportivo Cali Predictions

Main Match Prediction

Santa Fe To Win @ +102

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It could be beneficial to back Santa Fe when they clash with Deportivo Cali. There’s loads of value in the +102 that Los Cardenales get the job done and we’re therefore going to play the Full-Time Result market.

Continue below for our full Santa Fe vs Deportivo Cali betting breakdown, where you can read the complete analysis of our main match prediction, as well as our correct score prediction, player prop picks and bet builder tips.

Santa Fe vs Deportivo Cali Preview

Santa Fe take on Deportivo Cali at El Campín, with kick-off set for 21:00 on Tuesday 22 September.

Santa Fe have collected 16 points from nine Clausura matches and arrive on the back of consecutive victories. Their latest outing produced a 4-1 win away to Alianza Petrolera, with Nahuel Bustos scoring twice and Alexis Zapata and Hugo Rodallega also getting on the scoresheet.

Deportivo Cali sit one point behind with 15 points from nine Clausura games, having also won back-to-back matches. Their most recent success was a 3-0 home victory against Cúcuta, with Eduard Bello scoring twice before Steven Rodriguez added the third.

H2H: Last Head-to-Head Encounter Ended in a 1-1 Draw

Santa Fe haven’t lost to Cali in their past nine games, with their last clash ending 1-1. The previous 10 H2H games have featured six Santa Fe wins, three draws and one Cali victory.

Categoria Primera A		G	W	D	L	GF	GA	GD	GD	P
3	Deportivo Cali	17	9	6	2	26	10	16	26:10	33
6	Santa Fe	17	8	4	5	23	18	5	23:18	28

View Full Table

Main Match Prediction

We really like Santa Fe at odds of +102 to win this Primera A game, with this bet making lots of appeal. There’s a nice potential return and we think a victory could be on the cards.

Key stats supporting our main match prediction (league matches):

• Santa Fe have won 6 of their last 10 games at home.
• Santa Fe have won 3 of their last 5 games.
• Santa Fe have won 2 consecutive games.
• Cali have lost 11 of their last 20 games on the road.
• Santa Fe have won 6 of their last 10 games against Cali.

The latest injuries and suspensions can affect the overall outcome and we use this information as well as the form guide. The same applies to the stats so that we can get the best understanding of how things might pan out.

If you go by the best football betting sites, our pick has a 49.5% chance of delivering a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 55-60%. It is therefore regarded as a value bet.

If you’re anticipating that both teams will find the net, why not check out the Santa Fe to win + BTTS Yes option which is available at bigger odds on the Result & Both Teams to Score market.

Looking for the best betting offers? Our expert guide includes a wide range of welcome bonuses and free bets just for you.

Santa Fe To Win @ +102 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 21, 03:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santa Fe 1 - 0 Cali

Let’s take a chance on the +420 available that Santa Fe secure a 1-0 victory. There’s a nice potential return waiting if we’re able to predict the correct score.

Player Prop Picks

Top Pick: Omar Fernandez To Score +230

Omar Fernandez (Santa Fe) can be wagered at +230 to be on the scoresheet. It’s worth a play that he is Anytime Goalscorer as there’s lots of value for these betting odds.

Latest Omar Fernandez Player Prop Odds

Goalscorer

Anytime

+230

First

+450

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santa Fe vs Deportivo Cali Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The bookies have Santa Fe as -122 favourites for this Primera A clash, with the Full-Time Result betting odds implying that they are 55% likely to win. Deportivo Cali are trading at a bigger price than their opponents and the outsiders can be backed at +325.

The Asian Handicap -0.5 provides the chance to bet on Santa Fe to effectively win. If you want to oppose them, there’s the alternative to back Cali +0.5 at -115 and that gets the draw onside.

A low-scoring contest will be predicted by several which is reflected in the fact that Under 2.5 Goals has the shortest odds. Both Teams to Score No is available at -137 for anyone expecting at least one side to draw a blank.

The top betting sites always do a great job when it comes to Primera A games. They provide football bettors with hundreds of markets and you can cherry-pick the most attractive options.

Full-Time Result

1

-122

X

+230

2

+325

Half-Time Result

1

+143

X

+108

2

+360

Double Chance

1X

-556

12

-370

X2

-122

Draw No Bet

1

-294

2

+190

Asian Handicap

1 Hcp -0.5

-125

2 Hcp +0.5

-115

Total Goals

Under 2.5

-167

Over 2.5

+116

Both Teams to Score

Yes

-105

No

-137

Hugo Rodallega is the market leader to be First Goalscorer at +260 while there’s also the chance to back him to find the net at +120.

Hugo Rodallega (Santa Fe)

First

+260

Anytime

+120

Omar Fernandez (Santa Fe)

First

+450

Anytime

+230

Steven Rodriguez (Cali)

First

+500

Anytime

+255

Franco Fagúndez (Santa Fe)

First

+550

Anytime

+260

Nahuel Bustos (Santa Fe)

First

+600

Anytime

+310

Andres Amaya (Santa Fe)

First

+650

Anytime

+325

Avilés Hurtado (Cali)

First

+700

Anytime

+340

Jáder Obrian (Santa Fe)

First

+750

Anytime

+350

Juan Dinenno (Cali)

First

+800

Anytime

+375

Emerson Rodriguez (Santa Fe)

First

+800

Anytime

+390

Alexis Zapata (Santa Fe)

First

+850

Anytime

+400

Johan Martínez (Cali)

First

+850

Anytime

+410

Carlos Bacca (Cali)

First

+850

Anytime

+430

Luis Angel Palacios (Santa Fe)

First

+900

Anytime

+450

Nicolás Benedetti (Cali)

First

+1050

Anytime

+500

Maximiliano Lovera (Santa Fe)

First

+1000

Anytime

+510

Eduard Bello (Cali)

First

+1200

Anytime

+600

Christian Mafla (Santa Fe)

First

+1200

Anytime

+600

Leandro Angulo (Santa Fe)

First

+1200

Anytime

+650

Yilmar Andres Velasquez (Santa Fe)

First

+1300

Anytime

+650

Emanuel Reynoso (Cali)

First

+1400

Anytime

+700

Jose Caldera (Cali)

First

+1500

Anytime

+750

Ewil Murillo (Santa Fe)

First

+1600

Anytime

+800

Iván Scarpeta (Santa Fe)

First

+1700

Anytime

+850

Kevin Balanta (Santa Fe)

First

+1700

Anytime

+900

Mateo Puerta (Santa Fe)

First

+1800

Anytime

+900

Kalazan Suarez (Cali)

First

+1800

Anytime

+950

Juan Sebastian Quintero (Santa Fe)

First

+1900

Anytime

+950

Emanuel Olivera (Santa Fe)

First

+2000

Anytime

+1000

Kilian Toscano (Santa Fe)

First

+1900

Anytime

+1100

Santa Fe vs Deportivo Cali Lineups & Team News

Always review the Santa Fe vs Cali team news before locking in your bets. We’ll bring you the confirmed Primera A lineups along with up-to-date injury news.

Santa Fe Team Page Deportivo Cali Team Page

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