Santa Fe vs River Plate Prediction, Betting Tips, Lineups & Odds | 19 Aug 2026

Santa Fe vs River Plate Predictions

Main Match Prediction

Santa Fe Asian Hcp +0.25 @ -122

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Santa Fe look a good bet to defeat River Plate and we can back the home team at -122 with a +0.25 goal start on the Asian Handicap. This means splitting the stake equally between 0 and +0.5 in the quest for a return.

Read our complete Santa Fe vs River Plate betting preview for the full analysis behind our main match prediction, as well as our correct score prediction, player prop picks and bet builder tips.

Santa Fe vs River Plate Preview

Colombian Categoría Primera A team Santa Fe host Argentine Primera División outfit River Plate in the first leg of their Copa Sudamericana Round of 16 tie at Estadio El Campín, with kick-off set for 20:30 on Wednesday 19 August.

The game was initially scheduled for last week but was postponed following a major earthquake in Colombia.

Santa Fe, currently seventh in the Primera A, won their last game 2-0. This was a home triumph against Boyacá Chicó, with Hugo Rodallega and a Juan Palma own goal winning the game for Los Cardenales.

River Plate, who sit fourth in the Primera División, secured a 2-0 home victory over Argentinos Juniors on Sunday. Los Millonarios recorded 41% possession and had three shots on goal, with Gonzalo Montiel and Angel Correa on the scoresheet.

In their final Copa Libertadores group-stage games, Santa Fe claimed a 3-0 away victory over Venezuelan Primera División side Caracas, while River recorded a 3-0 home win against Bolivian Primera División outfit Blooming.

Copa Sudamericana		G	W	D	L	GF	GA	GD	GD	P
1	River Plate	6	4	2	0	9	3	6	9:3	14

Confirmed Lineups

Santa Fe confirmed lineup (4-2-3-1): Weimar Asprilla (GK), Helibelton Palacios, Emanuel Olivera, Kevin Balanta, Christian Mafla, Daniel Torres, Kilian Toscano, Jader Obrian, Nahuel Lautaro Bustos, Alexis Zapata, Hugo Rodallega.

River Plate confirmed lineup (4-2-3-1): Santiago Beltran (GK), Lucas Martinez Quarta, Nicolas Otamendi, Lautaro Rivero, Facundo Gonzalez, Anibal Moreno, Fausto Vera, Tobias Andrada, Angel Correa, Tomas Galvan, Rafael Santos Borre.

Main Match Prediction

We’re backing Santa Fe at -122 in this Copa Sudamericana game with a +0.25 goal start. We think that the home team will have the edge and we can therefore feel confident of a return with this bet.

Key stats supporting our main match prediction (domestic league and Copa Sudamericana matches):

• The +0.25 line has been covered by Santa Fe in 7 consecutive games at home.
• The +0.25 line has been covered by Santa Fe in 9 of their last 10 games.
• The +0.25 line has been covered by Santa Fe in 17 of their last 20 games.
• The -0.25 line hasn’t been covered by River in 4 of their last 5 games.
• The -0.25 line hasn’t been covered by River in 6 of their last 10 games.
• The -0.25 line hasn’t been covered by River in 2 consecutive games on the road.

Team news plays a valuable role and our football experts are always monitoring the players who have an injury concern. We’ve also got a handle on the form guide, with plenty of Copa Sudamericana data provided which puts you in the picture in terms of stats.

The best betting apps make it a 54.9% chance that our pick is settled as a winner. However, we have this number closer to 60% based on our in-depth research. This bet can therefore be backed with confidence.

It’s great to place a Winning Margin wager if you want an alternative to Asian Handicap. Choose whether a team will achieve a close victory or something bigger.

Your next bet could start with a welcome bonus. Explore our expert guide to the newest sign-up and betting offers.

Santa Fe Asian Hcp +0.25 @ -122 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Aug 18, 02:57). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santa Fe 1 - 0 River

Santa Fe are available at +575 to secure a 1-0 victory. Many bettors enjoy a correct score wager and there are some nice potential returns to be had.

Player Prop Picks

Top Pick: Omar Fernandez Over 0.5 Shots On Target -111

Omar Fernandez (Santa Fe) can be wagered to finish with a minimum of one shot on goal at -111. Shots on Target bettors should definitely consider him at the available odds and we’ll have a play.

Latest Omar Fernandez Player Prop Odds

Goalscorer

Anytime

+300

First

--100

Shots On Target

Over 0.5

-106

Under 0.5

-

---

Hugo Rodallega To Score +210

Hugo Rodallega (Santa Fe) can be backed to be on the scoresheet at +210. The Anytime Goalscorer odds look really appealing considering all angles and we’ll take a chance on him.

Latest Hugo Rodallega Player Prop Odds

Goalscorer

Anytime

+220

First

--100

Shots On Target

Over 0.5

-213

Under 0.5

-

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santa Fe vs River Plate Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With the bookmakers affording them a 43% chance of winning, River Plate might be a popular accumulator selection. Their betting odds are +130 when it comes to this Copa Sudamericana encounter. If you want to back the outsider, Santa Fe are available at +245.

You can back River at -189 on the Draw No Bet market, with money back if the game is a draw. Santa Fe are +125 and this could be an attractive option for those who want some insurance.

If you think there will be two goals or less during the ninety minutes, then Under 2.5 Goals is a potential option. If you’re expecting at least one team to draw a blank, then the No option on the Both Teams to Score market is available at -137.

The best betting sites push the boat out to ensure that football bettors can select from hundreds of markets. You can access them for every Copa Sudamericana match before making a decision.

Full-Time Result

1

+245

X

+185

2

+130

Half-Time Result

1

+290

X

-112

2

+190

Double Chance

1X

-172

12

-250

X2

-345

Draw No Bet

1

+125

2

-189

Asian Handicap

1 Hcp +0.25

-120

2 Hcp -0.25

-110

Total Goals

Under 2.5

-200

Over 2.5

+145

Both Teams to Score

Yes

-100

No

-137

Hugo Rodallega (Santa Fe)

First

-

Anytime

+220

Ángel Correa (River)

First

-

Anytime

+250

Omar Fernandez (Santa Fe)

First

-

Anytime

+300

Rafael Borré (River)

First

-

Anytime

+330

Mauro Arambarri (River)

First

-

Anytime

+350

Franco Fagúndez (Santa Fe)

First

-

Anytime

+380

Nahuel Bustos (Santa Fe)

First

-

Anytime

+450

Thiago Almada (River)

First

-

Anytime

+480

Tomás Galván (River)

First

-

Anytime

+480

Jáder Obrian (Santa Fe)

First

-

Anytime

+550

Alexis Zapata (Santa Fe)

First

-

Anytime

+550

Luis Angel Palacios (Santa Fe)

First

-

Anytime

+575

Fausto Vera (River)

First

-

Anytime

+600

Maximiliano Lovera (Santa Fe)

First

-

Anytime

+650

Gonzalo Montiel (River)

First

-

Anytime

+650

Yilmar Andres Velasquez (Santa Fe)

First

-

Anytime

+800

Christian Mafla (Santa Fe)

First

-

Anytime

+850

Iván Scarpeta (Santa Fe)

First

-

Anytime

+1100

Aníbal Moreno (River)

First

-

Anytime

+1150

Juan Carlos Portillo (River)

First

-

Anytime

+1150

Kevin Balanta (Santa Fe)

First

-

Anytime

+1150

Nicolás Otamendi (River)

First

-

Anytime

+1150

Tobias Palacio (River)

First

-

Anytime

+1150

Marcos Acuña (River)

First

-

Anytime

+1200

Francisco Ortega (River)

First

-

Anytime

+1200

Lucas Martínez (River)

First

-

Anytime

+1200

Kilian Toscano (Santa Fe)

First

-

Anytime

+1300

Daniel Torres (Santa Fe)

First

-

Anytime

+1300

Helibelton Palacios (Santa Fe)

First

-

Anytime

+1400

Emanuel Olivera (Santa Fe)

First

-

Anytime

+1400

Hugo Rodallega (Santa Fe)

Over 0.5

-213

Under 0.5

-

Ángel Correa (River)

Over 0.5

-182

Under 0.5

-

Rafael Borré (River)

Over 0.5

-127

Under 0.5

-

Omar Fernandez (Santa Fe)

Over 0.5

-106

Under 0.5

-

Mauro Arambarri (River)

Over 0.5

-104

Under 0.5

-

Franco Fagúndez (Santa Fe)

Over 0.5

+105

Under 0.5

-

Tomás Galván (River)

Over 0.5

+130

Under 0.5

-

Nahuel Bustos (Santa Fe)

Over 0.5

+145

Under 0.5

-

Thiago Almada (River)

Over 0.5

+145

Under 0.5

-

Jáder Obrian (Santa Fe)

Over 0.5

+170

Under 0.5

-

Fausto Vera (River)

Over 0.5

+170

Under 0.5

-

Alexis Zapata (Santa Fe)

Over 0.5

+180

Under 0.5

-

Luis Angel Palacios (Santa Fe)

Over 0.5

+185

Under 0.5

-

Maximiliano Lovera (Santa Fe)

Over 0.5

+200

Under 0.5

-

Gonzalo Montiel (River)

Over 0.5

+200

Under 0.5

-

Yilmar Andres Velasquez (Santa Fe)

Over 0.5

+280

Under 0.5

-

Christian Mafla (Santa Fe)

Over 0.5

+290

Under 0.5

-

Aníbal Moreno (River)

Over 0.5

+380

Under 0.5

-

Francisco Ortega (River)

Over 0.5

+390

Under 0.5

-

Iván Scarpeta (Santa Fe)

Over 0.5

+400

Under 0.5

-

Juan Carlos Portillo (River)

Over 0.5

+400

Under 0.5

-

Kevin Balanta (Santa Fe)

Over 0.5

+400

Under 0.5

-

Nicolás Otamendi (River)

Over 0.5

+400

Under 0.5

-

Tobias Palacio (River)

Over 0.5

+400

Under 0.5

-

Marcos Acuña (River)

Over 0.5

+400

Under 0.5

-

Lucas Martínez (River)

Over 0.5

+400

Under 0.5

-

Kilian Toscano (Santa Fe)

Over 0.5

+450

Under 0.5

-

Daniel Torres (Santa Fe)

Over 0.5

+450

Under 0.5

-

Emanuel Olivera (Santa Fe)

Over 0.5

+480

Under 0.5

-

Helibelton Palacios (Santa Fe)

Over 0.5

+500

Under 0.5

-

Latest Copa Sudamericana and domestic league stats. Full Time Result, Goals, Corners and Possession.

Santa Fe Stats

River Plate Stats

Full-Time Result

• 5 wins, 2 defeats and 3 draws in the previous 10 matches
• 6 wins, 1 defeat and 3 draws in the previous 10 home matches

Full-Time Result

• 4 wins, 5 defeats and 1 draw in the previous 10 matches
• 5 wins, 3 defeats and 2 draws in the previous 10 away matches

Goals

• An average of 2.30 goals scored and 1.20 conceded in the previous 10 matches
• An average of 2.20 goals scored and 0.70 conceded in the previous 10 home matches
• An average of 3.50 goals per game in the previous 10 matches
• An average of 2.90 goals per game in the previous 10 home matches
• BTTS Yes in 5 of the previous 10 matches
• BTTS Yes in 5 of the previous 10 home matches
• Over 2.5 Goals in 5 of the previous 10 matches
• Over 2.5 Goals in 5 of the previous 10 home matches

Goals

• An average of 1.10 goals scored and 0.80 conceded in the previous 10 matches
• An average of 1.10 goals scored and 0.70 conceded in the previous 10 away matches
• An average of 1.90 goals per game in the previous 10 matches
• An average of 1.80 goals per game in the previous 10 away matches
• BTTS Yes in 2 of the previous 10 matches
• BTTS Yes in 4 of the previous 10 away matches
• Over 2.5 Goals in 2 of the previous 10 matches
• Over 2.5 Goals in 2 of the previous 10 away matches

Santa Fe vs River Plate Lineups & Team News

Make sure you're up to date on the Santa Fe vs River team news before betting. We’ll keep you posted with predicted and confirmed lineups for the Copa Sudamericana and all current injury news.

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