Santos vs San Lorenzo Prediction, Betting Tips, Lineups & Odds | 20 May 2026

Copa Sudamericana Betting Preview: Santos vs San Lorenzo

Brazilian Série A team Santos host Argentine Primera División side San Lorenzo, with kick-off set for 18:00 on Wednesday 20 May.

The best strategy could be to back Under 2.5 on the Total Goals market at a price of -147. This looks like a standout wager, with Santos and San Lorenzo set to contest a low-scoring contest.

Santos were defeated last time out and that was in Série A. They were beaten at home to Coritiba by a 3-0 scoreline. Cuca's team dominated possession with 64% of the ball and had three shots on target.

San Lorenzo lost their previous game. On the road, they suffered a Primera División penalty shootout defeat (2-2 AET) against River Plate. El Ciclón recorded just 27% possession and had four shots on goal, with Rodrigo Auzmendi and Fabricio Lopez both on target.

In the last Copa Sudamericana round, Santos drew 1-1 away to Recoleta, while there was a 0-0 San Lorenzo draw away to Deportivo Cuenca.

Head-to-Head Statistics

There was a 1-1 draw when the sides last met, with Santos travelling to San Lorenzo.

Copa Sudamericana		G	W	D	L	GF	GA	GD	GD	P
1	San Lorenzo	4	1	3	0	4	2	2	4:2	6
4	Santos	4	0	3	1	3	4	-1	3:4	3

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Santos vs San Lorenzo Prediction & Betting Tips

Get the full betting picture for Santos vs San Lorenzo, including our expert match prediction, likely scoreline, must-watch player props and a tailored bet builder ready to use.

Match Prediction

We could be set for a low-scoring Copa Sudamericana encounter. We will therefore bet on Under 2.5 which can be backed at an eye-catching price of -147, with defences set to be on top for the most part.

In order to come up with the best football predictions, we like to know the Copa Sudamericana team news and study the latest form. There are also plenty of numbers to crunch from the available stats.

Key Santos vs San Lorenzo Copa Sudamericana & league stats:

• The 2.5 line hasn’t been covered in 4 of the last 5 Santos games.
• The 2.5 line hasn’t been covered in 7 of the last 10 Santos games.
• The 2.5 line hasn’t been covered in the last 11 San Lorenzo games on the road.
• The 2.5 line hasn’t been covered in 18 of the last 20 San Lorenzo games.

According to the latest odds, our pick has a 59.5% chance of winning. However, our tipsters in-depth research has found that the actual probability is between 65-70%. The bet can be recommended for this precise reason.

If you’re in search of a larger price and anticipate things being tight, then it might be worth looking at Under 1.5 Goals, with less than two goals needing to be scored overall.

Ready to boost your bet? Explore a huge selection of welcome bonuses in our regularly updated betting offers guide.

Our Match Prediction

Under 2.5 Goals @ -147 Watch Live Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (May 19, 00:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santos 1 - 1 San Lorenzo

We’ve found an attractive bet at odds of +475 and it involves the game ending in a 1-1 scoreline. We like a wager on correct score as there’s the chance to bank a bigger return.

Player Prop Picks

Top Pick: Rodrigo Auzmendi to Score +480

Rodrigo Auzmendi (San Lorenzo) has racked up three goals in his past five away matches. We’re happy to take the +480 for this Anytime Goalscorer bet as there’s value in the odds that he finds the net at least once.

Latest Rodrigo Auzmendi Player Prop Odds

Goalscorer

Anytime

+480

First

+1100

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santos vs San Lorenzo Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Santos betting odds are -141 which means that they’re favourites to land victory in this Copa Sudamericana encounter. It’s also suggested by the bookies that this team have a 58% chance of winning. If you want to back the outsider, San Lorenzo are available at +400.

Betting Santos -0.75 on the Asian Handicap at -109 means splitting stake between -0.5 and -1.0. Therefore, a one-goal win over San Lorenzo means a win and a push, with a 2+ goal victory meaning a full payout.

The Total Goals price implies that Under 2.5 is the most likely result in this contest. If you think this points to a low-scoring or one-sided affair, then BTTS No could be an option at -133.

If you’re betting on Copa Sudamericana matches, we recommend heading to the top football betting sites and scanning through the hundreds of markets. There’s a chance to bet pre-match and In-Play.

Full-Time Result

1

-141

X

+255

2

+400

Half-Time Result

1

+133

X

+110

2

+410

Double Chance

1X

-625

12

-370

X2

+102

Draw No Bet

1

-385

2

+235

Asian Handicap

1 Hcp -0.75

-109

2 Hcp +0.75

-122

Total Goals

Under 2.5

-147

Over 2.5

+108

Both Teams to Score

Yes

-103

No

-133

There is +170 available that Neymar finds the net at any stage. He is available at +390 to register the first goal which makes him favourite.

Neymar (Santos)

First

+170

Anytime

+390

Moisés Vieira da Veiga (Santos)

First

+175

Anytime

+430

Gabigol (Santos)

First

+205

Anytime

+475

Ronielson Rony (Santos)

First

+260

Anytime

+600

Alexis Cuello (San Lorenzo)

First

+290

Anytime

+700

Luciano Vietto (San Lorenzo)

First

+310

Anytime

+750

Álvaro Barreal (Santos)

First

+350

Anytime

+800

Lautaro Díaz (Santos)

First

+350

Anytime

+800

Thaciano Mickael Silva (Santos)

First

+420

Anytime

+1000

Christian Oliva (Santos)

First

+430

Anytime

+1050

Miguel Terceros (Santos)

First

+450

Anytime

+1000

Matías Hernández (San Lorenzo)

First

+475

Anytime

+1200

Benjamín Rollheiser (Santos)

First

+480

Anytime

+1150

Rodrigo Auzmendi (San Lorenzo)

First

+480

Anytime

+1100

Gabriel Menino (Santos)

First

+600

Anytime

+1400

Gabriel Bontempo (Santos)

First

+600

Anytime

+1400

Diego Herazo (San Lorenzo)

First

+600

Anytime

+1500

Matías Reali (San Lorenzo)

First

+650

Anytime

+1500

Vinicius Rodrigues Lira (Santos)

First

+650

Anytime

+1600

Nahuel Barrios (San Lorenzo)

First

+650

Anytime

+1600

Francisco Perruzzi (San Lorenzo)

First

+850

Anytime

+2000

Marcelo Torrez (Santos)

First

+850

Anytime

+2200

Mayke Rocha Oliveira (Santos)

First

+900

Anytime

+2200

José Ivaldo Silva (Santos)

First

+900

Anytime

+2200

Luan Peres Petroni (Santos)

First

+900

Anytime

+2200

Latest Copa Sudamericana and domestic league stats. Full Time Result, Goals, Corners and Possession.

Santos Stats

San Lorenzo Stats

Full-Time Result

• 2 wins, 3 defeats and 5 draws in the previous 10 matches
• 4 wins, 3 defeats and 3 draws in the previous 10 home matches

Full-Time Result

• 3 wins, 2 defeats and 5 draws in the previous 10 matches
• 1 win, 2 defeats and 7 draws in the previous 10 away matches

Goals

• An average of 1.10 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.30 goals scored and 1.20 conceded in the previous 10 home matches
• An average of 2.40 goals per game in the previous 10 matches
• An average of 2.50 goals per game in the previous 10 home matches
• BTTS Yes in 6 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 home matches
• Over 2.5 Goals in 3 of the previous 10 matches
• Over 2.5 Goals in 4 of the previous 10 home matches

Goals

• An average of 1.20 goals scored and 1.00 conceded in the previous 10 matches
• An average of 0.90 goals scored and 1.00 conceded in the previous 10 away matches
• An average of 2.20 goals per game in the previous 10 matches
• An average of 1.90 goals per game in the previous 10 away matches
• BTTS Yes in 4 of the previous 10 matches
• BTTS Yes in 4 of the previous 10 away matches
• Over 2.5 Goals in 1 of the previous 10 matches
• Over 2.5 Goals in 0 of the previous 10 away matches

Corners

• An average of 4.67 corners awarded and 5.17 corners conceded in the last 6 matches
• An average of 5.22 corners awarded and 4.44 corners against in the last 9 home matches
• An average of 9.83 corners awarded in the last 6 matches
• An average of 9.67 corners awarded in the last 9 home matches
• Had the most corners in 2 and least corners in 3 of the last 6 matches
• Had the most corners in 5 and least corners in 3 of the last 9 home matches

Corners

• An average of 3.67 corners awarded and 4.17 corners conceded in the last 6 matches
• An average of 2.75 corners awarded and 4.88 corners against in the last 8 away matches
• An average of 7.83 corners awarded in the last 6 matches
• An average of 7.63 corners awarded in the last 8 away matches
• Had the most corners in 3 and least corners in 3 of the last 6 matches
• Had the most corners in 3 and least corners in 5 of the last 8 away matches

Possession

• An average of 48.83% possession in the last 6 matches
• An average of 52.00% possession in the last 9 home matches
• Most possession in 2 of the last 6 matches
• Most possession in 5 of the last 9 home matches

Possession

• An average of 46.50% possession in the last 6 matches
• An average of 45.00% possession in the last 8 away matches
• Most possession in 3 of the last 6 matches
• Most possession in 2 of the last 8 away matches

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Santos vs San Lorenzo Lineups & Team News

Stay ahead of the game by checking the Santos vs San Lorenzo team news before betting. We’ll have the predicted and confirmed Copa Sudamericana lineups for you plus all the latest on player injuries.

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