Chiefs vs Chargers Prediction, Picks & Odds | 05 Sep 2025

NFL Betting Preview: Chiefs vs Chargers

The AFC champions and Super Bowl runners-up Kansas City Chiefs lock horns with the Los Angeles Chargers in this NFL Week 1 matchup at SoFi Stadium, with kickoff scheduled for 20:00 on Friday, September 5. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

The market might have underrated the Chargers and -105 makes lots of appeal considering the underdogs are +3 on the spread. Back them to cover the line against the Chiefs.

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Kansas City Chiefs lost their last game, a 40–22 defeat to the Philadelphia Eagles in Super Bowl LIX at Caesars Superdome. It marked the franchise’s third consecutive Super Bowl appearance.

The Chiefs generated 275 total yards of offense, with 226 coming through the air and 49 on the ground. They picked up 12 first downs and scored three touchdowns, all via the passing game.

Los Angeles Chargers suffered a defeat in their last game. A 32-12 scoreline occurred on the road at NRG Stadium against Houston Texans. The Chargers recorded 261 yards, split between 211 passing and 50 rushing yards. The offense produced 15 first downs and scored one touchdown.

Head-to-Head Statistics

The Chiefs won the most recent matchup between these teams. A 19-17 victory was registered against the Chargers at GEHA Field at Arrowhead Stadium. In the past 10 H2H meetings, the Chiefs have won eight.

Quarterbacks

Patrick Mahomes

253.5 Passing Yards

Over -114

Under -114

Justin Herbert

233.5 Passing Yards

Over -114

Under -114

Chiefs vs Chargers Prediction & Picks

Get the edge with our best Chiefs vs Chargers tips: a key match prediction, correct score recommendation, top player prop bets and a ready-made bet builder.

Game Prediction

We’re confident that the Chargers can push for a victory in this NFL matchup and the +3 about the underdogs on the spread makes appeal. Take -105 that they cover the line.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Chiefs vs Chargers stats:

• The +3 line has been covered by Chargers in 15 of their last 20 games at home.
• The +3 line has been covered by Chargers in 7 of their last 10 games.
• The -3 line hasn’t been covered by Chiefs in 2 consecutive games on the road.
• The +3 line has been covered by Chargers in 7 of their last 10 games against Chiefs.

Chargers +3 Probability

The top NFL sportsbooks make it a 51.3% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. This is why we regard this as a value bet.

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your point spread pick. It all comes down to how confident you feel.

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Our Game Prediction

Chargers +3 @ -105 Bet Now

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Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Player Prop Picks

Top Pick: Justin Herbert Over 231.5 Passing Yards -114

Justin Herbert (Chargers) can be backed at -114 to go beyond 231.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can place this bet with confidence.

Latest Justin Herbert Player Prop Odds

Touchdown

Anytime

+490

First

+2500

Passing Yards

Over 233.5

-114

Under 233.5

-114

Rushing Yards

Over 16.5

-114

Under 16.5

-114

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Travis Kelce Anytime TD +155

You can back Travis Kelce (Chiefs) at odds of +155 to score a TD. Based on all the evidence, we're happy to back him to punch it in on the Anytime Touchdown Scorer market.

Latest Travis Kelce Player Prop Odds

Touchdown

Anytime

+160

First

+900

Receiving Yards

Over 50.5

-114

Under 50.5

-114

Correct Score Prediction

Chiefs 23 - 27 Chargers

We’ll throw a dart when it comes to the Chargers claiming a 27-23 victory. This correct score prediction is available at monster odds and could be an entertaining wager to place.

Chiefs vs Chargers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

With a 63% chance of securing victory, Kansas City Chiefs are favorites for this game and the sportsbooks have them at betting odds of -172. For those wanting to oppose the market leader, you can get +144 about Los Angeles Chargers.

The spread currently stands at 3 and the total points line is 47.5. NFL fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 47.5 at -115.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Moneyline

Chiefs

-172

Chargers

+144

Point Spread

Chiefs -3

-118

Chargers +3

-104

Total Points

Under 47.5

-115

Over 47.5

-105

There is +110 available that Xavier Worthy scores a TD at any stage. He is available at +650 to record the first touchdown which makes him favorite.

Touchdown

Xavier Worthy (Chiefs)

First TD

+650

Anytime TD

+110

Omarion Hampton (Chargers)

First TD

+750

Anytime TD

+145

Isiah Pacheco (Chiefs)

First TD

+800

Anytime TD

+165

Rashee Rice (Chiefs)

First TD

+850

Anytime TD

+160

Travis Kelce (Chiefs)

First TD

+900

Anytime TD

+160

Ladd McConkey (Chargers)

First TD

+1000

Anytime TD

+170

Marquise Brown (Chiefs)

First TD

+1200

Anytime TD

+220

Najee Harris (Chargers)

First TD

+1400

Anytime TD

+240

Keenan Allen (Chargers)

First TD

+1600

Anytime TD

+290

Kareem Hunt (Chiefs)

First TD

+1700

Anytime TD

+280

Quentin Johnston (Chargers)

First TD

+1900

Anytime TD

+350

JuJu Smith-Schuster (Chiefs)

First TD

+2200

Anytime TD

+470

Noah Gray (Chiefs)

First TD

+2200

Anytime TD

+430

Patrick Mahomes (Chiefs)

First TD

+2200

Anytime TD

+440

Justin Herbert (Chargers)

First TD

+2500

Anytime TD

+490

Will Dissly (Chargers)

First TD

+2700

Anytime TD

+600

Tyler Conklin (Chargers)

First TD

+3000

Anytime TD

+600

Kansas City Chiefs Defense (Chiefs)

First TD

+3000

Anytime TD

+650

Kimani Vidal (Chargers)

First TD

+3500

Anytime TD

+750

Los Angeles Chargers Defense (Chargers)

First TD

+4000

Anytime TD

+850

Tyquan Thornton (Chiefs)

First TD

+4500

Anytime TD

+600

Tre Harris (Chargers)

First TD

+6000

Anytime TD

+850

KeAndre Lambert-Smith (Chargers)

First TD

+8000

Anytime TD

+1100

Hassan Haskins (Chargers)

First TD

+8000

Anytime TD

+1400

Brashard Smith (Chiefs)

First TD

+8000

Anytime TD

+1200

Derius Davis (Chargers)

First TD

+10000

Anytime TD

+1800

Jared Wiley (Chiefs)

First TD

+10000

Anytime TD

+1500

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+2700

Oronde Gadsden II (Chargers)

First TD

+10000

Anytime TD

+2000

Robert Tonyan (Chiefs)

First TD

+10000

Anytime TD

+2000

Scott Matlock (Chargers)

First TD

+10000

Anytime TD

+2700

Receiving Yards

Ladd McConkey (Chargers)

Over 68.5

-114

Under 68.5

-114

Rashee Rice (Chiefs)

Over 61.5

-114

Under 61.5

-114

Xavier Worthy (Chiefs)

Over 60.5

-114

Under 60.5

-114

Travis Kelce (Chiefs)

Over 50.5

-114

Under 50.5

-114

Keenan Allen (Chargers)

Over 39.5

-114

Under 39.5

-114

Marquise Brown (Chiefs)

Over 36.5

-114

Under 36.5

-114

Quentin Johnston (Chargers)

Over 27.5

-114

Under 27.5

-114

Noah Gray (Chiefs)

Over 19.5

-114

Under 19.5

-114

JuJu Smith-Schuster (Chiefs)

Over 19.5

-114

Under 19.5

-114

Will Dissly (Chargers)

Over 15.5

-114

Under 15.5

-114

Tyler Conklin (Chargers)

Over 15.5

-114

Under 15.5

-114

Omarion Hampton (Chargers)

Over 12.5

-114

Under 12.5

-114

Isiah Pacheco (Chiefs)

Over 9.5

-115

Under 9.5

-111

Rushing Yards

Omarion Hampton (Chargers)

Over 46.5

-114

Under 46.5

-114

Isiah Pacheco (Chiefs)

Over 45.5

-114

Under 45.5

-114

Najee Harris (Chargers)

Over 24.5

-114

Under 24.5

-114

Kareem Hunt (Chiefs)

Over 22.5

-114

Under 22.5

-114

Patrick Mahomes (Chiefs)

Over 17.5

-114

Under 17.5

-114

Justin Herbert (Chargers)

Over 16.5

-114

Under 16.5

-114

Xavier Worthy (Chiefs)

Over 4.5

-102

Under 4.5

-125

Passing Yards

Patrick Mahomes (Chiefs)

Over 253.5

-114

Under 253.5

-114

Justin Herbert (Chargers)

Over 233.5

-114

Under 233.5

-114

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Chiefs Have Won Last Five Head-to-Head Meetings at SoFi Stadium

The Chargers have a 5-5 record in their last 10 home games, averaging 22.70 points on offense and surrendering 21.30 on defense.

The Chiefs have a 7-3 record in their last 10 games on the road, averaging 21.70 points scored and 21.70 points allowed.

The Chiefs earned a 17-10 win over the Chargers the last time they played at SoFi Stadium. From 5 head-to-head games at SoFi Stadium, the Chiefs have been victorious in all.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Chargers Home Stats		5-5	44.00	22.70	21.30	4	6
Chiefs Away Stats		7-3	43.40	21.70	21.70	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Kansas City Chiefs Stats

Los Angeles Chargers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -3 Betting Line: Have covered the spread in 6 of the last 10 games
• -3 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• +3 Betting Line: Have covered the spread in 7 of the last 10 games
• +3 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 44.00 pts in the previous 10 games
• Game Totals on the Road: An average of 43.40 pts in the previous 10 games on the road
• Over 46.5: Covered in 3 of the previous 10 games
• Over 46.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.20 pts and allowed 21.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.70 pts and allowed 21.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.70 pts in the previous 10 games
• Game Totals at Home: An average of 44.00 pts in the previous 10 home games
• Over 46.5: Covered in 6 of the previous 10 games
• Over 46.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 25.50 pts and allowed 23.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.70 pts and allowed 21.30 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 304.60 Yds. Allowed 353.10 Yds
• Rushing Yards: Gained 91.00 Yds. Allowed 130.90 Yds
• Passing Yards: Gained 213.60 Yds. Allowed 222.20 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 18.70. Allowed 21.00
• Total Turnovers: Committed 0.40. Committed by opponents 1.20
• Total Penalties: Committed 5.90. Committed by opponents 6.80
• Penalty Yards: Lost 50.90 Yds. Gained 54.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 325.20 Yds. Allowed 351.30 Yds
• Rushing Yards: Gained 101.60 Yds. Allowed 130.20 Yds
• Passing Yards: Gained 223.60 Yds. Allowed 221.10 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.30. Allowed 19.90
• Total Turnovers: Committed 0.90. Committed by opponents 1.10
• Total Penalties: Committed 5.50. Committed by opponents 6.90
• Penalty Yards: Lost 39.70 Yds. Gained 65.20 Yds

Last 10 Games on the Road

• Total Yards: Gained 306.00 Yds. Allowed 322.70 Yds
• Rushing Yards: Gained 101.50 Yds. Allowed 109.40 Yds
• Passing Yards: Gained 204.50 Yds. Allowed 213.30 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 18.40. Allowed 19.90
• Total Turnovers: Committed 1.10. Committed by opponents 1.50
• Total Penalties: Committed 6.20. Committed by opponents 6.10
• Penalty Yards: Lost 56.20 Yds. Gained 41.40 Yds

Last 10 Home Games

• Total Yards: Gained 315.90 Yds. Allowed 358.50 Yds
• Rushing Yards: Gained 110.10 Yds. Allowed 130.40 Yds
• Passing Yards: Gained 205.80 Yds. Allowed 228.10 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 18.50. Allowed 18.10
• Total Turnovers: Committed 0.50. Committed by opponents 1.10
• Total Penalties: Committed 5.30. Committed by opponents 6.50
• Penalty Yards: Lost 37.90 Yds. Gained 61.20 Yds

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