Fresno State vs USC Prediction, Picks & Odds | 04 Sep 2026
College Football Betting Preview: Fresno State vs USC
Fresno State go up against USC at LA Memorial Coliseum, with kickoff scheduled for 21:00 on Friday, September 4.
Fresno State can give a good account of themselves against USC. They can prevent a big loss and there is -110 available that the underdogs cover the +21.5 spread.
Fresno State Bulldogs previous game saw them claim a 18-3 win over Miami-Ohio Redhawks at Arizona Stadium.
USC Trojans last game saw them claim a 42-26 home win over San Jose State Spartans at LA Memorial Coliseum.
Head-to-Head Statistics
It was a 45-17 win for USC at LA Memorial Coliseum when they last played Fresno State.
Quarterbacks
Jayden Mandal
Jayden Maiava
Fresno State vs USC Prediction & Picks
Get the full betting picture for Fresno State vs USC, including our expert match prediction, likely scoreline, must-watch player props and a tailored bet builder ready to use.
Game Prediction
Fresno State have been given a more than generous +21.5 line on the spread. We think they can avoid a big loss in this college football matchup and you can play them at -110.
The college football picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every pick.
Key Fresno State vs USC stats:
Fresno State +21.5 Probability
When you look at the latest odds, our pick has a 52.4% chance of delivering a return. Based on our cappers in-depth research, we calculate the actual probability to be closer to 60%. The wager can be recommended for this precise reason.
If you want a good alternative to betting Fresno State on the spread, then the Winning Margin lines could be up your street. Choose from a range of options.
Don’t place a bet without checking our guide full of top-tier betting offers, from free bets to welcome bonus incentives.
Player Prop Picks
The odds for Jayden Maiava (USC) to record fewer than 257.5 passing yards stand at -114. The line looks too high and we’re confident he’ll fall short of the QB Passing Yards total.
Mark Bowman (Fresno State) can be backed at -114 to end with fewer than 31.5 receiving yards. We’re confident he’ll fall short of the Player Receiving Yards line, as the total looks too high.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve got a same game parlay with three options: Fresno State +21.5, Under 51.5 points and Jayden Maiava (USC) to go Under 257.5 passing yards.
The same game parlay option is fantastic for football bettors wanting a personalised multi-leg wager on the same game. It’s especially good if you have a strong opinion on the likely outcomes and the odds for each selection are combined.
Correct Score Prediction
17
-
31
USC
There are some huge returns lying in wait if you can get the correct score right. With this in mind, we’ll have a play on the Trojans to enjoy a 31-17 winning scoreline.
Fresno State vs USC Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
At betting odds of -3333 with the sportsbooks, USC are regarded as 97% likely to win this college game. Fresno State are regarded as a long shot to win and you can currently back them at +1200.
21.5 is the spread and 51.5 is the total points line. Football bettors regularly enjoy the opportunity to wager on the Totals. Those that want to back Under 51.5 can find odds of -110 available.
There’s no shortage of betting opportunities when it comes to college football. The best betting apps offer a wide variety of team props and game lines for each game, so be sure to explore both the pre-game and in-game markets before making your pick.
Receiving Yards
Rushing Yards
Passing Yards
USC Building a Fortress at Home
USC have strung together eight consecutive wins at LA Memorial Coliseum. They have a 9-1 record in their last 10 home games, averaging 40.60 points on offense and surrendering 22.00 on defense.
Fresno State have gone 5-5 across their last 10 games away from home, averaging 23.70 points on offense and surrendering 28.50 on defense.
The last time the teams met at LA Memorial Coliseum, USC defeated Fresno State 45-17.
| Last 10 Games | W-L | P | PF | PA | O51.5 | U51.5 | |
|---|---|---|---|---|---|---|---|
 USC Home Stats |
9-1 | 62.60 | 40.60 | 22.00 | 6 | 4 | |
 Fresno State Away Stats |
5-5 | 52.20 | 23.70 | 28.50 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O51.5 = Games Over 51.5 Points
- U51.5 = Games Under 51.5 Points
Latest regular season and playoff games stats.
Fresno State Bulldogs Stats
USC Stats
- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- +21.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +21.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -21.5 Betting Line: Have not covered the spread in any of the last 10 games
- -21.5 Betting Line at Home: Have covered the spread in 2 of the last 10 home games
- Game Totals: An average of 42.20 pts in the previous 10 games
- Game Totals on the Road: An average of 52.20 pts in the previous 10 games on the road
- Over 51.5: Covered in 3 of the previous 10 games
- Over 51.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 25.00 pts and allowed 17.20 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 23.70 pts and allowed 28.50 pts in the last 10 games on the road
- Game Totals: An average of 54.10 pts in the previous 10 games
- Game Totals at Home: An average of 64.40 pts in the previous 10 home games
- Over 51.5: Covered in 6 of the previous 10 games
- Over 51.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 29.70 pts and allowed 24.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 41.30 pts and allowed 23.10 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
USC
|
1 | 0 | 42 | 26 | 16 | 1-0 | 0-0 | 1W |
Ohio State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Washington
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
UCLA
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Rutgers
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Purdue
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Penn State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Oregon
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Northwestern
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Illinois
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Nebraska
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Minnesota
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Michigan
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Michigan State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Maryland
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Iowa
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Indiana
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Wisconsin
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
| Pacific-12 | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Boise State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Colorado State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
|
Fresno State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Oregon State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
San Diego State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Utah State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Washington State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
Texas State
|
0 | 0 | 0 | 0 | 0 | 0-0 | 0-0 | - |
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