Missouri vs Mississippi State Prediction, Picks & Odds | 26 Sep 2026

College Football Betting Preview: Missouri vs Mississippi State

Missouri go up against Mississippi State at Davis Wade Stadium, with kickoff scheduled for 19:45 on Saturday, September 26.

We’re making Missouri against the spread our prediction when they face Mississippi State. The betting line is favorably set at +6.5 and you can secure -114 that this happens.

Missouri Tigers made it three consecutive wins after a 27-17 home success over Troy Trojans at Faurot Field.

Mississippi State Bulldogs won last time out by a 41-34 scoreline. On the road against South Carolina Gamecocks at Williams-Brice Stadium, they made it three wins on the spin.

Head-to-Head Statistics

Missouri have beaten Mississippi State in the last two matchups. They won 39-20 at Davis Wade Stadium and triumphed 49-27 at Faurot Field. It’s been two Missouri wins in the past 3 games between these teams.

Quarterbacks

Austin Simmons

236.5 Passing Yards

Over -114

Under -114

Kamario Taylor

254.5 Passing Yards

Over -114

Under -114

Missouri vs Mississippi State Prediction & Picks

This expert Missouri vs Mississippi State betting breakdown features our match prediction, a correct score tip, player prop suggestions and a carefully constructed bet builder to guide your wagers.

Game Prediction

There’s a great opportunity to back Missouri against the spread here. The underdogs should be able to produce a solid performance in this college football battle, with +6.5 making lots appeal at -114.

Injuries can influence the outcome and our CFB handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the matchup might unfold.

Key Missouri vs Mississippi State stats:

• The +6.5 line has been covered by Missouri in 5 consecutive games.
• The +6.5 line has been covered by Missouri in 17 of their last 20 games.
• The +6.5 line has been covered by Missouri in 7 of their last 10 games.
• The -6.5 line hasn’t been covered by Mississippi State in 4 of their last 5 games at home.
• The -6.5 line hasn’t been covered by Mississippi State in 7 of their last 10 games.
• The -6.5 line hasn’t been covered by Mississippi State in 2 consecutive games against Missouri.

Mizzou +6.5 Probability

According to the top sportsbooks, there’s a 53.2% likelihood of our pick landing a return. Our analysts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It’s the reason why we are recommending this college bet.

The Winning Margin lines allow you to bet on Mizzou to secure a victory by a certain number of points. It’s a different wager and a viable alternative to the point spread.

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Our Game Prediction

Missouri +6.5 @ -114 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 25, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kamario Taylor Under 254.5 Passing Yards -114

The odds for Kamario Taylor (Mississippi State) to have less than 254.5 passing yards stand at -114. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Kamario Taylor Player Prop Odds

Passing Yards

Over 254.5

-114

Under 254.5

-114

Rushing Yards

Over 48.5

-114

Under 48.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Missouri 24 - 27 MS State

There are massive odds available when it comes to the Bulldogs claiming a 27-24 victory. A close battle is anticipated between two evenly-matched teams.

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Missouri vs Mississippi State Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have Mississippi State at -222 when it comes to the Moneyline betting, implying the market leaders are 69% likely to win this college game according to the latest odds. If you’re looking for an alternative angle, Missouri are trading at +180.

The spread currently stands at 6.5 and the total points line is 58.5. A Total bet relates to the number of points that will be scored overall. Those expecting a low total can back Under 58.5 at -104.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

Missouri

+180

MS State

-222

Point Spread

Missouri +6.5

-114

MS State -6.5

-106

Total Points

Under 58.5

-104

Over 58.5

-118

Receiving Yards

Anthony Evans III (MS State)

Over 77.5

-114

Under 77.5

-114

Donovan Olugbode (Missouri)

Over 72.5

-114

Under 72.5

-114

Cayden Lee (Missouri)

Over 59.5

-114

Under 59.5

-114

Zion Ragins (MS State)

Over 41.5

-114

Under 41.5

-114

Sanfrisco Magee (MS State)

Over 37.5

-114

Under 37.5

-114

Marquis Johnson (MS State)

Over 34.5

-114

Under 34.5

-114

Sam West (MS State)

Over 11.5

-114

Under 11.5

-114

Fluff Bothwell (MS State)

Over 5.5

-114

Under 5.5

-114

Rushing Yards

Jamal Roberts (Missouri)

Over 97.5

-114

Under 97.5

-114

Fluff Bothwell (MS State)

Over 85.5

-114

Under 85.5

-114

Kamario Taylor (MS State)

Over 48.5

-114

Under 48.5

-114

Austin Simmons (Missouri)

Over 4.5

-114

Under 4.5

-114

Passing Yards

Kamario Taylor (MS State)

Over 254.5

-114

Under 254.5

-114

Austin Simmons (Missouri)

Over 236.5

-114

Under 236.5

-114

Mississippi State Have Collected Five Wins in Past Ten Home Games

Mississippi State own a 5-5 mark in their past 10 home games, scoring 36.40 points per contest and conceding 26.70.

Missouri have gone 5-5 across their last 10 games away from home, averaging 23.20 points on offense and surrendering 22.10 on defense.

The last time the teams met at Davis Wade Stadium, Missouri defeated Mississippi State 39-20.

Last 10 Games		W-L	P	PF	PA	O58.5	U58.5
Mississippi State Home Stats		5-5	63.10	36.40	26.70	7	3
Missouri Away Stats		5-5	45.30	23.20	22.10	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O58.5 = Games Over 58.5 Points
• U58.5 = Games Under 58.5 Points

Latest regular season and playoff games stats.

Missouri Tigers Stats

Mississippi State Bulldogs Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 46.00 pts in the previous 10 games
• Game Totals on the Road: An average of 45.30 pts in the previous 10 games on the road
• Over 58.5: Covered in 3 of the previous 10 games
• Over 58.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 26.20 pts and allowed 19.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.20 pts and allowed 22.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 66.80 pts in the previous 10 games
• Game Totals at Home: An average of 63.80 pts in the previous 10 home games
• Over 58.5: Covered in 7 of the previous 10 games
• Over 58.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 33.40 pts and allowed 33.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 34.80 pts and allowed 29.00 pts in the last 10 home games

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