Nebraska vs Michigan State Prediction, Picks & Odds | 26 Sep 2026

College Football Betting Preview: Nebraska vs Michigan State

Nebraska go up against Michigan State at Spartan Stadium, with kickoff scheduled for 17:00 on Saturday, September 26.

We’ve lined up a prediction which requires Michigan State to keep close to Nebraska. We think that the line of +5.5 can be covered and you can secure -106.

Nebraska Cornhuskers have won their previous three games. The latest was a 34-7 home triumph at Memorial Stadium against North Dakota Fighting Hawks.

Michigan State Spartans have enjoyed two home wins in a row. They were defeated in their last game when losing 27-10 on the road against Notre Dame Fighting Irish.

Head-to-Head Statistics

Nebraska beat Michigan State when the teams last met. It was a 38-27 scoreline at Memorial Stadium. In the past 3 games between the teams, Michigan State have won two.

Quarterbacks

Anthony Colandrea

208.5 Passing Yards

Over -114

Under -114

Alessio Milivojevic

189.5 Passing Yards

Over -114

Under -114

Nebraska vs Michigan State Prediction & Picks

Unlock a complete betting breakdown for Nebraska vs Michigan State, featuring our expert match prediction, expected final score, standout player prop picks and a ready-to-play bet builder.

Game Prediction

There’s the chance to back Michigan State to cover the +5.5 line in this college football matchup. Betting the underdogs on the spread seems the logical play and there is -106 now available.

Our CFB picks always start with checking the latest team news and understanding how it might impact the game. From there, we dive into the most valuable stats to uncover the insights that matter most.

Key Nebraska vs Michigan State stats:

• The +5.5 line has been covered by Michigan State in 4 of their last 5 games.
• The +5.5 line has been covered by Michigan State in 6 of their last 10 games at home.
• The +5.5 line has been covered by Michigan State in 3 consecutive games at home.
• The -5.5 line hasn’t been covered by Nebraska in 9 of their last 10 games on the road.
• The -5.5 line hasn’t been covered by Nebraska in 16 of their last 20 games on the road.
• The -5.5 line hasn’t been covered by Nebraska in 2 consecutive games on the road.
• The +5.5 line has been covered by Michigan State in 2 of their last 3 games against Nebraska.

Michigan State +5.5 Probability

If you go by the best sportsbooks, our pick has a 51.5% prospect of winning. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. That means we are regarding it as a value wager.

Selling points can be a fantastic option and allows bettors to enjoy a bigger return on the same selection. For a more conservative spread pick, you can alternatively buy points.

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Our Game Prediction

Michigan State +5.5 @ -106 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 24, 23:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Alessio Milivojevic Over 189.5 Passing Yards -114

Alessio Milivojevic (Michigan State) can be backed at -114 to reach over 189.5 passing yards. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.

Latest Alessio Milivojevic Player Prop Odds

Passing Yards

Over 189.5

-114

Under 189.5

-114

---

Anthony Colandrea Over 23.5 Rushing Yards -118

Anthony Colandrea (Michigan State) is priced at -118 to go over 23.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest Anthony Colandrea Player Prop Odds

Passing Yards

Over 208.5

-114

Under 208.5

-114

Rushing Yards

Over 23.5

-118

Under 23.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Nebraska 27 - 30 Michigan State

There are massive odds available when it comes to the Spartans claiming a 30-27 victory. A close battle is anticipated between two evenly-matched teams.

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Nebraska vs Michigan State Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have Nebraska at -208 when it comes to the Moneyline betting, implying the market leaders are 68% likely to win this college game according to the latest odds. Michigan State are the underdogs at +172 and they’re regarded as least likely to win.

There is a spread of 5.5 and total points has a line of 48.5. There is no denying the popularity of wagering on the Totals. Those that want to back Under 48.5 can find odds of -108 available.

You’ll find a great variety of team props and game lines for most college football showdowns. The best betting apps provide a strong mix of pre-game and in-game options to suit your betting style.

Moneyline

Nebraska

-208

MSU

+172

Point Spread

Nebraska -5.5

-114

MSU +5.5

-106

Total Points

Under 48.5

-108

Over 48.5

-112

Receiving Yards

Jacory Barney Jr. (Nebraska)

Over 55.5

-114

Under 55.5

-114

Kwazi Gilmer (Nebraska)

Over 46.5

-114

Under 46.5

-114

Chrishon McCray (MSU)

Over 34.5

-114

Under 34.5

-114

Jayden Savoury (MSU)

Over 26.5

-114

Under 26.5

-114

Rushing Yards

Cam Edwards (MSU)

Over 69.5

-114

Under 69.5

-114

Jamal Rule (Nebraska)

Over 64.5

-114

Under 64.5

-114

Mekhi Nelson (Nebraska)

Over 36.5

-114

Under 36.5

-114

Anthony Colandrea (Nebraska)

Over 23.5

-118

Under 23.5

-112

Passing Yards

Anthony Colandrea (Nebraska)

Over 208.5

-114

Under 208.5

-114

Alessio Milivojevic (MSU)

Over 189.5

-114

Under 189.5

-114

Michigan State Hold Six Wins From Last Ten at Home

Michigan State are 6-4 in their last 10 home games, averaging 25.20 points on offense and surrendering 25.20 on defense.

Nebraska have three wins and seven losses in the last 10 road games, scoring 17.40 points per matchup and conceding 29.20.

Michigan State defeated Nebraska 20-17 when the teams last met at Spartan Stadium.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Michigan State Home Stats		6-4	50.40	25.20	25.20	6	4
Nebraska Away Stats		3-7	46.60	17.40	29.20	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Latest regular season and playoff games stats.

Nebraska Cornhuskers Stats

Michigan State Spartans Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -5.5 Betting Line on the Road: Have covered the spread in 1 of the last 10 games on the road

Point Spread

• +5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +5.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 50.90 pts in the previous 10 games
• Game Totals on the Road: An average of 46.60 pts in the previous 10 games on the road
• Over 48.5: Covered in 6 of the previous 10 games
• Over 48.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 26.60 pts and allowed 24.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.40 pts and allowed 29.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.60 pts in the previous 10 games
• Game Totals at Home: An average of 52.90 pts in the previous 10 home games
• Over 48.5: Covered in 5 of the previous 10 games
• Over 48.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 20.60 pts and allowed 26.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.60 pts and allowed 26.30 pts in the last 10 home games

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