Northwestern vs Indiana Prediction, Picks & Odds | 25 Sep 2026
College Football Betting Preview: Northwestern vs Indiana
Northwestern go up against Indiana at Memorial Stadium, with kickoff scheduled for 20:00 on Friday, September 25.
We’re confident that Indiana can enjoy a big win when playing Northwestern, leading us to go against the spread at -20.5. This line makes plenty of appeal and there are odds of -122 available.
Northwestern Wildcats have won their previous two games. The latest was a 41-7 home triumph at Ryan Field against Colorado Buffaloes.
Indiana Hoosiers were winners for the third straight time in their last game. Landing a 38-0 home victory against Western Kentucky Hilltoppers at Memorial Stadium.
Head-to-Head Statistics
Indiana won the last matchup between the pair. Enjoying a 41-24 triumph when facing Northwestern at Northwestern Medicine Field at Martin Stadium.
Quarterbacks
Aidan Chiles
Josh Hoover
Northwestern vs Indiana Prediction & Picks
Discover our expert Northwestern vs Indiana betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.
Game Prediction
We have decided to go for Indiana against the spread in order to get the best value. They should be able to cover the -20.5 line at odds of -122 for this college football showdown.
Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.
Key Northwestern vs Indiana stats:
Indiana -20.5 Probability
According to the best betting apps, our pick has a 54.9% chance of winning. However, our analysts have this number closer to 60% based on their in-depth research. It is the reason why we are recommending this college wager.
There are many betting alternatives to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.
Get extra value on your next wager with our list of betting offers—featuring welcome bonuses, free bets, and promotions.
Player Prop Picks
Nick Marsh (Indiana) can be backed at -115 to score a TD. We think this is the pick of the player props, with generous odds available when it comes to backing him to score a touchdown at any time.
You can place a bet on Griffin Wilde (Northwestern) at -114 to go beyond 58.5 receiving yards. We're confident in him covering the Player Receiving Yards line and hitting our Over bet.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Indiana to cover the -20.5 spread, Under 49.5 on the total and a touchdown to be scored by Nick Marsh (Indiana).
A same game parlay allows bettors to place a multiple wager on the same football game. You can go through the available betting lines and cherry-pick the outcomes that you think will happen. The odds for each selection are then combined together.
Correct Score Prediction
10
-
35
Indiana
If you want to take a chance on a correct score, then the Hoosiers to achieve a 35-10 win could be along the right lines. There are huge odds for this particular outcome.
Northwestern vs Indiana Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
You might not get rich backing Indiana at -2500. However, the sportsbooks’ betting odds imply a 96% chance of winning this college game. If you’re looking for an alternative angle, Northwestern are trading at +1060.
The current spread is 20.5 and the total points line is 49.5. Football fans love the chance to get an alternative angle by going for a Total wager. Those that want to back Under 49.5 can find odds of -110 available.
If you’re wagering on college football, we recommend heading to the best betting sites and scanning through the huge selection of team props and game lines. There’s the opportunity to bet pre-game and in-game.
Charlie Becker is the market leader to be First TD Scorer at +340. Alternatively, there’s the opportunity to back him to register a touchdown at any stage at -189.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Indiana Looking to Extend Strong Home Form
Indiana have gone 10-0 across their last 10 home games, putting up 48.90 points on average and giving up 7.50.
Northwestern have stumbled to three straight defeats on the road. They have a 3-7 record in their last 10 road games, scoring 16.40 points per contest and conceding 27.40.
Indiana earned a 34-3 win against Northwestern in the teams’ last meeting at Memorial Stadium.
| Last 10 Games | W-L | P | PF | PA | O49.5 | U49.5 | |
|---|---|---|---|---|---|---|---|
 Indiana Home Stats |
10-0 | 56.40 | 48.90 | 7.50 | 7 | 3 | |
 Northwestern Away Stats |
3-7 | 43.80 | 16.40 | 27.40 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O49.5 = Games Over 49.5 Points
- U49.5 = Games Under 49.5 Points
Latest regular season and playoff games stats.
Northwestern Wildcats Stats
Indiana Hoosiers Stats
- 6 wins and 4 defeats in the last 10 games
- 3 wins and 7 defeats in the last 10 games on the road
- 10 wins and 0 defeats in the last 10 games
- 10 wins and 0 defeats in the last 10 home games
- +20.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +20.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -20.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -20.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 45.90 pts in the previous 10 games
- Game Totals on the Road: An average of 43.80 pts in the previous 10 games on the road
- Over 49.5: Covered in 3 of the previous 10 games
- Over 49.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 26.10 pts and allowed 19.80 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 16.40 pts and allowed 27.40 pts in the last 10 games on the road
- Game Totals: An average of 49.90 pts in the previous 10 games
- Game Totals at Home: An average of 55.20 pts in the previous 10 home games
- Over 49.5: Covered in 5 of the previous 10 games
- Over 49.5 at Home: Covered in 6 of the previous 10 home games
- Team Totals: Have scored an average of 39.30 pts and allowed 10.60 pts in the last 10 games
- Team Totals at Home: Have scored an average of 45.40 pts and allowed 9.80 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
UCLA
|
3 | 0 | 125 | 72 | 53 | 2-0 | 1-0 | 3W |
USC
|
4 | 0 | 172 | 91 | 81 | 3-0 | 1-0 | 4W |
|
Indiana
|
3 | 0 | 145 | 16 | 129 | 3-0 | 0-0 | 3W |
Maryland
|
2 | 1 | 126 | 49 | 77 | 1-1 | 1-0 | 1L |
Wisconsin
|
2 | 1 | 103 | 60 | 43 | 2-0 | 0-1 | 2W |
Oregon
|
2 | 1 | 149 | 66 | 83 | 2-0 | 0-1 | 1W |
Ohio State
|
2 | 1 | 138 | 30 | 108 | 2-0 | 0-1 | 1W |
Minnesota
|
2 | 1 | 113 | 52 | 61 | 2-1 | 0-0 | 1W |
Michigan State
|
2 | 1 | 75 | 54 | 21 | 2-0 | 0-1 | 1L |
Illinois
|
2 | 1 | 117 | 64 | 53 | 2-1 | 0-0 | 1W |
Iowa
|
3 | 0 | 111 | 13 | 98 | 3-0 | 0-0 | 3W |
Washington
|
3 | 0 | 88 | 40 | 48 | 3-0 | 0-0 | 3W |
Penn State
|
3 | 0 | 127 | 22 | 105 | 2-0 | 1-0 | 3W |
|
Northwestern
|
2 | 0 | 75 | 25 | 50 | 2-0 | 0-0 | 2W |
Nebraska
|
3 | 0 | 139 | 35 | 104 | 3-0 | 0-0 | 3W |
Michigan
|
3 | 0 | 82 | 39 | 43 | 3-0 | 0-0 | 3W |
Purdue
|
1 | 2 | 118 | 109 | 9 | 1-1 | 0-1 | 2L |
Rutgers
|
0 | 3 | 77 | 107 | -30 | 0-2 | 0-1 | 3L |
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