Ohio State vs Iowa Prediction, Picks & Odds | 03 Oct 2026

College Football Betting Preview: Ohio State vs Iowa

No. 5 Ohio State faces No. 14 Iowa in this Week 5 matchup at Kinnick Stadium, with kickoff scheduled for 15:30 on Saturday, October 3.

The best bet could be Iowa at -118 on the spread. They’ve been given a +14.5 points start and the underdogs should be able to stay relatively close to Ohio State.

This is the centerpiece of Saturday’s slate, with College GameDay in Iowa City for a top-15 Big Ten showdown. Ohio State faces a demanding road assignment against an Iowa team carrying major national relevance, and the atmosphere at Kinnick Stadium should match the stakes as both programs chase position in the conference and CFP picture.

The Ohio State Buckeyes are 3-1 after a dominant 42-19 home victory over the Illinois Fighting Illini. Quarterback Julian Sayin threw for 367 yards and four touchdowns, while Jeremiah Smith delivered a career performance with 12 catches for 217 yards and four touchdowns, tying the program’s single-game record for touchdown receptions.

The Iowa Hawkeyes are 4-0 this season after extending their perfect start with a dramatic 20-19 road victory over the Michigan Wolverines. Quarterback Hank Brown threw for 227 yards and two touchdowns, including a 16-yard game-winning pass to Reece Vander Zee as time expired. Vander Zee finished with 66 receiving yards and both of Iowa’s second-half touchdowns.

Head-to-Head Statistics

Ohio State won the last meeting against Iowa, earning a 35-7 victory at Ohio Stadium.

Ohio State vs Iowa Prediction & Picks

We cover the essential Ohio State vs Iowa betting angles, featuring our main match prediction, correct score guidance and a carefully crafted bet builder.

Game Prediction

Our pick is that Iowa might not be beaten heavily in this college football matchup. They have been afforded a generous +14.5 and we recommend backing the underdogs at -118.

Recent form is always part of the equation and we combine it with team news as soon as it’s available. To deliver expert predictions, our college football handicappers also analyze the latest stats to ensure we’re working with the best information possible.

Key Ohio State vs Iowa stats:

• The +14.5 line has been covered by Iowa in 20 consecutive games.

Iowa +14.5 Probability

The top sportsbooks imply that our pick has a 54.1% prospect of winning. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. This college wager can therefore be backed with confidence.

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Our Game Prediction

Iowa +14.5 @ -118 Bet Now

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Correct Score Prediction

Ohio State 24 - 17 Iowa

There is a speculative bet that can be enjoyed on the Buckeyes when it comes to the correct score lines. Taking them to win 24-17 should provide some entertainment.

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Ohio State vs Iowa Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You might not get rich backing Ohio State at -667. However, the sportsbooks’ betting odds imply a 87% chance of winning this college game. Iowa are the underdogs at +470 and they’re regarded as least likely to win.

The current spread is 14.5 and the total points line is 45.5. A Total wager is always available and can often provide value selections. There’s the chance to back Under 45.5 at -110.

You can find a nice selection of game lines and team props for every college football game, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Ohio State

-667

Iowa

+470

Point Spread

Ohio State -14.5

-104

Iowa +14.5

-118

Total Points

Under 45.5

-110

Over 45.5

-110

There is regularly value to be found from betting the quarterback and player props with the best online gambling sites. You can find lots of ways to back for or against a specific player lining up for one of the two teams.

Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Iowa Racking Up the Home Wins

Iowa have strung together four straight victories at Kinnick Stadium. They own a 8-2 mark in their past 10 home games, putting up 30.90 points per contest and giving up 10.90.

Ohio State are 9-1 in their last 10 road games, averaging 31.00 points scored and 13.00 points allowed.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Iowa Home Stats		8-2	41.80	30.90	10.90	3	7
Ohio State Away Stats		9-1	44.00	31.00	13.00	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Latest regular season and playoff games stats.

Ohio State Buckeyes Stats

Iowa Hawkeyes Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• -14.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -14.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• +14.5 Betting Line: Have covered the spread in the last 10 games
• +14.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 47.90 pts in the previous 10 games
• Game Totals on the Road: An average of 44.00 pts in the previous 10 games on the road
• Over 45.5: Covered in 6 of the previous 10 games
• Over 45.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 35.50 pts and allowed 12.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 31.00 pts and allowed 13.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 44.20 pts in the previous 10 games
• Game Totals at Home: An average of 41.80 pts in the previous 10 home games
• Over 45.5: Covered in 4 of the previous 10 games
• Over 45.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 30.30 pts and allowed 13.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.90 pts and allowed 10.90 pts in the last 10 home games

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