Ohio State vs USC Prediction, Picks & Odds | 31 Oct 2026
Ohio State vs USC Predictions
Get with Ohio State with a -6.5 spread. We’re backing the favorites at -122 to enjoy a solid victory when they go head-to-head with USC.
Get our primary Ohio State vs USC betting predictions, built around our Best Bet, Player Props, Same Game Parlay and Correct Score Pick. Explore each section for the full analysis behind the plays.
Ohio State vs USC Preview
Ohio State go up against USC at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday, October 31.
Ohio State Buckeyes have won their previous five games. A 19-15 triumph recently occurred on the road at Memorial Stadium when playing Indiana Hoosiers.
USC Trojans were defeated in their last game. On the road, they suffered a 24-7 reverse against Wisconsin Badgers at Camp Randall Stadium.
Best Bet
Ohio State at -6.5 could be the best wager to have on the spread. -122 is available and our pick would mean a solid victory for the favorites in this college football matchup.
Key stats supporting our main match prediction:
We’re always on top of team news and when combined with recent form, it helps us uncover the best value. Our college football handicappers also take a data-led approach, using key stats to back every pick.
Ohio State -6.5 Probability
The top sportsbooks imply that our pick has a 54.9% prospect of winning. Based on our cappers in-depth research, we calculate the actual probability to be closer to 60%. The wager can be recommended for this precise reason.
If you are looking for bigger odds, then you can move the line by selling points. Choose how many to sell until you are happy with the juice available.
Before placing your next bet, explore our trusted bonus guide featuring top free bets and generous sign-up offers.
Player Prop Picks
The odds for Jayden Maiava (USC) to have less than 255.5 passing yards are -114. We're confident he’ll fall short of the QB Passing Yards line, so we're backing the Under.
The odds for Bo Jackson (USC) to end with fewer than 89.5 rushing yards are -114. There’s a strong case for opting for him to fall short of the required total in the Player Rushing Yards market.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Pick
Our same game parlay pick is Ohio State -6.5 on the spread, Over 51.5 and Jayden Maiava (USC) to go Under 255.5 passing yards.
A same game parlay is a fantastic option for bettors who want to focus their wagering on a single football game. You can predict different outcomes and see their odds combined before going ahead and placing this tailored bet.
Correct Score Prediction
34
-
20
USC
Should you wish to go for a speculative bet, try the Buckeyes to triumph 34-20 on the correct score lines. This should be a fun wager which could potentially yield a huge return.
Ohio State vs USC Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The Ohio State odds have been priced up by the sportsbooks and they are -250 betting favorites to land victory in this college game which means a 71% chance of winning. USC are the underdogs at +205 and they’re regarded as least likely to win.
6.5 is the spread and 51.5 is the total points line. The Totals offers football bettors an alternative way of getting involved. If you fancy Under 51.5, then the odds are -112.
If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.
Receiving Yards
Rushing Yards
USC Own Nine Victories From Previous Ten at Home
USC own a 9-1 mark in their past 10 home games, putting up 35.10 points per contest and giving up 21.00.
Ohio State have a 9-1 record in their last 10 games away from home, putting up 28.80 points on average and giving up 13.10.
| Last 10 Games | W-L | P | PF | PA | O51.5 | U51.5 | |
|---|---|---|---|---|---|---|---|
 USC Home Stats |
9-1 | 56.10 | 35.10 | 21.00 | 5 | 5 | |
 Ohio State Away Stats |
9-1 | 41.90 | 28.80 | 13.10 | 1 | 9 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O51.5 = Games Over 51.5 Points
- U51.5 = Games Under 51.5 Points
Latest regular season and playoff games stats.
Ohio State Buckeyes Stats
USC Stats
- 7 wins and 3 defeats in the last 10 games
- 9 wins and 1 defeat in the last 10 games on the road
- -6.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -6.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road
- +6.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +6.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 46.60 pts in the previous 10 games
- Game Totals on the Road: An average of 41.90 pts in the previous 10 games on the road
- Over 51.5: Covered in 4 of the previous 10 games
- Over 51.5 on the Road: Covered in 1 of the previous 10 games on the road
- Team Totals: Have scored an average of 32.60 pts and allowed 14.00 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 28.80 pts and allowed 13.10 pts in the last 10 games on the road
- Game Totals: An average of 55.80 pts in the previous 10 games
- Game Totals at Home: An average of 56.10 pts in the previous 10 home games
- Over 51.5: Covered in 6 of the previous 10 games
- Over 51.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 31.80 pts and allowed 24.00 pts in the last 10 games
- Team Totals at Home: Have scored an average of 35.10 pts and allowed 21.00 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
UCLA
|
7 | 0 | 241 | 107 | 134 | 4-0 | 3-0 | 7W |
|
Ohio State
|
6 | 1 | 275 | 94 | 181 | 4-0 | 2-1 | 5W |
Indiana
|
7 | 1 | 269 | 96 | 173 | 4-1 | 3-0 | 1W |
Northwestern
|
6 | 1 | 243 | 116 | 127 | 5-0 | 1-1 | 4W |
Minnesota
|
5 | 2 | 186 | 141 | 45 | 4-1 | 1-1 | 1W |
Wisconsin
|
5 | 2 | 189 | 107 | 82 | 4-0 | 1-2 | 1W |
|
USC
|
6 | 2 | 262 | 200 | 62 | 4-1 | 2-1 | 1L |
Iowa
|
5 | 2 | 196 | 100 | 96 | 3-1 | 2-1 | 1L |
Nebraska
|
5 | 2 | 249 | 108 | 141 | 4-1 | 1-1 | 2L |
Illinois
|
4 | 3 | 212 | 177 | 35 | 3-2 | 1-1 | 2W |
Oregon
|
4 | 3 | 232 | 145 | 87 | 3-1 | 1-2 | 1L |
Purdue
|
3 | 4 | 219 | 226 | -7 | 2-3 | 1-1 | 1L |
Michigan
|
4 | 3 | 142 | 110 | 32 | 4-2 | 0-1 | 1L |
Washington
|
4 | 3 | 195 | 159 | 36 | 3-2 | 1-1 | 1W |
Rutgers
|
2 | 5 | 201 | 233 | -32 | 1-3 | 1-2 | 1L |
Penn State
|
3 | 4 | 201 | 132 | 69 | 2-2 | 1-2 | 4L |
Maryland
|
2 | 5 | 198 | 233 | -35 | 1-3 | 1-2 | 5L |
Michigan State
|
2 | 6 | 159 | 206 | -47 | 2-3 | 0-3 | 6L |
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