Stanford vs Louisville Prediction, Picks & Odds | 31 Oct 2026

Stanford vs Louisville Predictions

Best Bet

Louisville -22.5 @ -110

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There’s everything to like about the -22.5 line that Louisville have to cover against Stanford. Take the -110 and feel confident that they get the job done.

Our Stanford vs Louisville betting guide features our Best Bet, Same Game Parlay and Correct Score Prediction. Scroll down to see the full breakdown and reasoning behind the card.

Stanford vs Louisville Preview

Stanford face Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 15:15 on Saturday, October 31.

Stanford Cardinal have lost three straight road games. In their previous appearance, they recorded a 31-28 home win over NC State Wolfpack at Stanford Stadium.

Louisville Cardinals won last time out by a 34-26 scoreline. On the road against Syracuse Orange at JMA Wireless Dome, they made it back-to-back wins.

H2H: Stanford Came Out on Top in Last H2H Clash

The scoreline was 38-35 in favor of Stanford when they last played Louisville, with the matchup taking place at Stanford Stadium.

Best Bet

We’re sweet on Louisville who are -22.5 on the spread. The favorites should enjoy a big win in this college football showdown and cover the line at -110.

Key stats supporting our main match prediction:

• The +22.5 line hasn’t been covered by Stanford in 4 of their last 5 games on the road.
• The +22.5 line hasn’t been covered by Stanford in 7 of their last 10 games on the road.
• The +22.5 line hasn’t been covered by Stanford in 3 consecutive games on the road.

The CFB handicappers at Sportsgambler.com always keep close tabs on team news as it develops. We also rely on recent form and key stats to help shape our picks and guide the final call.

Louisville -22.5 Probability

According to the latest betting odds, our pick has a 52.4% chance of winning. Taking all factors into consideration, our analysts think there’s a stronger chance of success and estimate the probability to be closer to 60%. This college wager can therefore be backed with confidence.

If you want to back Louisville without taking them on the point spread, there’s the alternative to go for a Winning Margin wager instead. There are lots of different options here.

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Louisville -22.5 @ -110 Bet Now

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Correct Score Prediction

Stanford 14 - 41 Louisville

There is a speculative bet that can be enjoyed on the Cards when it comes to the correct score lines. Taking them to win 41-14 should provide some entertainment.

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Stanford vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With an estimated 96% chance of winning, the sportsbooks are taking no chances with their -2500 betting odds about Louisville triumphing in this college game. Stanford are the underdogs at +1100 and they’re regarded as least likely to win.

22.5 is the spread and 59.5 is the total points line. A wager on the Totals allows football bettors to use the latest data to good effect. If you fancy Under 59.5, then the odds are -106.

The top sportsbooks offer a huge selection of team props and game lines when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Stanford

+1100

Louisville

-2500

Point Spread

Stanford +22.5

-110

Louisville -22.5

-110

Total Points

Under 59.5

-106

Over 59.5

-114

Louisville Have Six Wins From Past Ten Home Game

Louisville own a 6-4 mark in their past 10 home games, averaging 34.90 points scored and 21.90 points allowed.

Stanford have stumbled to ten consecutive losses away from home. They have zero win and ten losses in the last 10 games away from home, putting up 12.30 points on average and giving up 37.80.

Last 10 Games		W-L	P	PF	PA	O59.5	U59.5
Louisville Home Stats		6-4	56.80	34.90	21.90	4	6
Stanford Away Stats		0-10	50.10	12.30	37.80	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O59.5 = Games Over 59.5 Points
• U59.5 = Games Under 59.5 Points

Latest regular season and playoff games stats.

Stanford Cardinal Stats

Louisville Cardinals Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 0 wins and 10 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +22.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +22.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -22.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -22.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 55.30 pts in the previous 10 games
• Game Totals on the Road: An average of 50.10 pts in the previous 10 games on the road
• Over 59.5: Covered in 5 of the previous 10 games
• Over 59.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.00 pts and allowed 34.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 12.30 pts and allowed 37.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 59.70 pts in the previous 10 games
• Game Totals at Home: An average of 56.80 pts in the previous 10 home games
• Over 59.5: Covered in 5 of the previous 10 games
• Over 59.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 34.50 pts and allowed 25.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 34.90 pts and allowed 21.90 pts in the last 10 home games

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