Wake Forest vs Louisville Prediction, Picks & Odds | 26 Sep 2026
College Football Betting Preview: Wake Forest vs Louisville
Wake Forest square off against Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 12:00 on Saturday, September 26.
We have decided to go for Louisville against the spread in order to get the best value. They should be able to cover the -13.5 line at odds of -108 when they take on Wake Forest.
Wake Forest Demon Deacons were defeated in their previous game. They were beaten at home to Miami Hurricanes by a 33-20 scoreline at Allegacy Federal Credit Union Stadium.
Louisville Cardinals won their last game 41-31, making it successive victories. This was a home win at L&N Federal Credit Union Stadium against SMU Mustangs.
Head-to-Head Statistics
Louisville triumphed 48-21 when they last played Wake Forest. This head-to-head was played at L&N Federal Credit Union Stadium. The past 4 games between the teams have seen Louisville win three times.
Quarterbacks
Gio Lopez
Lincoln Kienholz
Wake Forest vs Louisville Prediction & Picks
Gear up for Wake Forest vs Louisville with our comprehensive betting guide, featuring an expert match prediction, scoreline advice, top player props and a hand-picked bet builder.
Game Prediction
There’s everything to like about the -13.5 line that the favorites have to cover in this college football battle. Take the -108 and feel confident that Louisville get the job done.
We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant stats, this gives us a strong foundation for accurate CFB picks.
Key Wake Forest vs Louisville stats:
Louisville -13.5 Probability
Based on the odds from the top betting apps, our pick has a 51.8% chance of landing a return. In our opinion, there’s actually a probability of success closer to 60%. This college bet can therefore be backed with confidence.
If you want to land a big potential return from a small stake, then a Bet Builder could be a good way to go. Back Louisville against the spread in a combination with other picks.
Thinking of betting? Browse our detailed guide for the best current offers, including free bets and the latest bonuses.
Player Prop Picks
You can back Lincoln Kienholz (Louisville) at -114 surpass 244.5 passing yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.
Carlos Hernandez (Louisville) can be backed at -114 to surpass 76.5 receiving yards. We're confident in him covering the Player Receiving Yards line and hitting our Over bet.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Louisville to cover the -13.5 spread, Over 57.5 on the total and Lincoln Kienholz (Louisville) to have Over 244.5 passing yards.
The same game parlay option allows you to combine different outcomes within the same game. You need all your predictions to be correct although bettors love to place a tailored football bet on the event which interests them most.
Correct Score Prediction
24
-
42
Louisville
There are lots of different betting angles including the chance to bet on the Cards on the correct score lines. For example, a 42-24 win in their favor is available at huge odds.
Wake Forest vs Louisville Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The latest Moneyline betting odds give Louisville a 85% chance of winning this college game which means they’re overwhelming -588 favorites with the sportsbooks. The market suggests that Wake Forest are least likely to win at +430.
The spread is calculated to be 13.5, while total points comes in at 57.5. The beauty of the Totals is that you only have to choose from one of two options. If you fancy Under 57.5, then the odds are -110.
The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.
Receiving Yards
Rushing Yards
Passing Yards
Louisville Looking to Extend Strong Home Form
Louisville have reeled off four consecutive victories at L&N Federal Credit Union Stadium. They have seven wins and three losses in the last 10 home games, averaging 34.60 points on offense and surrendering 20.00 on defense.
Wake Forest have six wins and four losses in the last 10 games on the road, averaging 27.00 points on offense and surrendering 29.90 on defense.
The last time these teams met at L&N Federal Credit Union Stadium, Louisville came out on top 48-21 against Wake Forest.
| Last 10 Games | W-L | P | PF | PA | O57.5 | U57.5 | |
|---|---|---|---|---|---|---|---|
 Louisville Home Stats |
7-3 | 54.60 | 34.60 | 20.00 | 3 | 7 | |
 Wake Forest Away Stats |
6-4 | 56.90 | 27.00 | 29.90 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O57.5 = Games Over 57.5 Points
- U57.5 = Games Under 57.5 Points
Latest regular season and playoff games stats.
Wake Forest Stats
Louisville Cardinals Stats
- 7 wins and 3 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +13.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +13.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -13.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -13.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 53.90 pts in the previous 10 games
- Game Totals on the Road: An average of 56.90 pts in the previous 10 games on the road
- Over 57.5: Covered in 4 of the previous 10 games
- Over 57.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 28.70 pts and allowed 25.20 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 27.00 pts and allowed 29.90 pts in the last 10 games on the road
- Game Totals: An average of 55.70 pts in the previous 10 games
- Game Totals at Home: An average of 54.60 pts in the previous 10 home games
- Over 57.5: Covered in 4 of the previous 10 games
- Over 57.5 at Home: Covered in 3 of the previous 10 home games
- Team Totals: Have scored an average of 32.30 pts and allowed 23.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 34.60 pts and allowed 20.00 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
3 | 0 | 155 | 33 | 122 | 1-0 | 2-0 | 3W |
Duke
|
3 | 0 | 83 | 37 | 46 | 2-0 | 1-0 | 3W |
Pittsburgh
|
3 | 0 | 98 | 34 | 64 | 3-0 | 0-0 | 3W |
California
|
2 | 1 | 94 | 70 | 24 | 1-1 | 1-0 | 2W |
Clemson
|
2 | 1 | 60 | 78 | -18 | 2-0 | 0-1 | 2W |
|
Louisville
|
2 | 1 | 138 | 85 | 53 | 2-0 | 0-1 | 2W |
Virginia
|
2 | 1 | 120 | 49 | 71 | 2-1 | 0-0 | 1L |
SMU
|
2 | 1 | 114 | 75 | 39 | 1-0 | 1-1 | 1L |
Georgia Tech
|
1 | 2 | 81 | 70 | 11 | 1-2 | 0-0 | 1W |
Virginia Tech
|
3 | 0 | 152 | 50 | 102 | 2-0 | 1-0 | 3W |
Boston College
|
2 | 1 | 65 | 71 | -6 | 2-0 | 0-1 | 2W |
Stanford
|
1 | 2 | 50 | 107 | -57 | 1-1 | 0-1 | 2L |
NC State
|
1 | 2 | 112 | 69 | 43 | 1-0 | 0-2 | 1L |
North Carolina
|
2 | 1 | 70 | 41 | 29 | 1-0 | 1-1 | 1L |
Florida State
|
1 | 2 | 94 | 94 | 0 | 1-1 | 0-1 | 2L |
|
Wake Forest
|
2 | 1 | 96 | 85 | 11 | 1-1 | 1-0 | 1L |
Syracuse
|
1 | 2 | 97 | 51 | 46 | 1-1 | 0-1 | 2L |
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