Washington vs USC Prediction, Picks & Odds | 03 Oct 2026

College Football Betting Preview: Washington vs USC

Washington square off against No. 18 USC in this Week 5 matchup at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday, October 3.

We’re not sure that USC and Washington will reach a certain points threshold. Our prediction is to take the -115 that there are Under 58.5 points.

Washington and USC meet in a prime-time Big Ten matchup featuring two of the West Coast’s biggest brands. The Trojans have little margin for error if they want to remain prominent in the conference and national pictures, while Washington has an opportunity to make a major statement away from home under the NBC spotlight.

The Washington Huskies are 3-1 this season after suffering their first defeat in a 27-24 home loss to the Minnesota Golden Gophers. Washington rallied late in the fourth quarter, with quarterback Demond Williams Jr. throwing for 239 yards and two touchdowns while adding a rushing score. Dezmen Roebuck caught seven passes for 87 yards and a touchdown.

The USC Trojans are 4-1 after suffering their first defeat in a 41-27 home loss to the Oregon Ducks. Quarterback Jayden Maiava threw for 326 yards and two touchdowns, while Kayden Dixon-Wyatt caught six passes for 114 yards and a touchdown. Oregon finished with 504 total yards as USC was outscored 28-17 in the second half.

Head-to-Head Statistics

Washington won the last meeting against USC, earning a 26-21 victory at Husky Stadium. The Huskies have won each of the past three matchups between the teams.

Washington vs USC Prediction & Picks

Our Washington vs USC betting tips provide expert coverage of all major angles, including our main match prediction, correct score recommendation and best bet builder insights.

Game Prediction

Play the Unders at -115 when these college football teams take to the field. The 58.5 points line looks plenty big enough and we’re not sure the pair will combine to get this total.

Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.

Key Washington vs USC stats:

• The 58.5 line hasn’t been covered in 4 of the last 5 Washington games.
• The 58.5 line hasn’t been covered in 3 of the last 4 Washington games this season.

Under 58.5 Probability

The top betting apps are suggesting that our pick has a 53.5% chance of delivering a return. However, we think that the probability is close to 60% taking all factors into consideration. It's why we think it’s worth placing this college wager.

Those looking for larger odds can include an Under pick with other selections when they place a Bet Builder. A bigger potential payout could be on the cards with this bet.

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Our Game Prediction

Under 58.5 Points @ -115 Bet Now

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Correct Score Prediction

Washington 24 - 28 USC

the Trojans are available at massive odds to register a 28-24 victory and they might have the edge. This should be a close matchup and there won’t be much between the teams.

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Washington vs USC Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have USC at -333 when it comes to the Moneyline betting, implying the market leaders are 77% likely to win this college game according to the latest odds. Washington are regarded as a long shot to win and you can currently back them at +260.

The spread is currently 9.5, with the total points line at 58.5. Having a bet on the Totals is one of the most popular football wagers. If you’re going for Under 58.5, this outcome can be backed at -115.

The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.

Moneyline

Washington

+260

USC

-333

Point Spread

Washington +9.5

-118

USC -9.5

-104

Total Points

Under 58.5

-115

Over 58.5

-105

Prop betting is very popular, with bettors looking to wager on quarterback and player props such as First/Last Touchdown Scorer, Passing Yards, Player Passing Attempts, Interceptions and Kicking Points. The gambling sites will provide plenty of options.

You don’t have to wait for the final outcome when it comes to college football micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

USC Hold Nine Wins in Previous Ten at Home

USC have nine wins and one loss in the last 10 games at home, putting up 38.50 points on average and giving up 20.90.

Washington own a 3-7 mark in their past 10 games away from home, averaging 22.60 points on offense and surrendering 27.10 on defense.

The last time the teams met at LA Memorial Coliseum, Washington defeated USC 52-42.

Last 10 Games		W-L	P	PF	PA	O58.5	U58.5
USC Home Stats		9-1	59.40	38.50	20.90	5	5
Washington Away Stats		3-7	49.70	22.60	27.10	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O58.5 = Games Over 58.5 Points
• U58.5 = Games Under 58.5 Points

Latest regular season and playoff games stats.

Washington Huskies Stats

USC Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 48.10 pts in the previous 10 games
• Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
• Over 58.5: Covered in 4 of the previous 10 games
• Over 58.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.30 pts and allowed 16.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.60 pts and allowed 27.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 59.80 pts in the previous 10 games
• Game Totals at Home: An average of 59.40 pts in the previous 10 home games
• Over 58.5: Covered in 5 of the previous 10 games
• Over 58.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 34.60 pts and allowed 25.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 38.50 pts and allowed 20.90 pts in the last 10 home games

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