West Virginia vs Iowa State Prediction, Picks & Odds | 03 Oct 2026
West Virginia vs Iowa State Predictions
We’re bullish about Iowa State on the spread at -2.5. They should be able to win by a comfortable margin in their clash against West Virginia and you can get odds of -122.
We highlight the top West Virginia vs Iowa State picks with our Best Bet, Same Game Parlay and Correct Score Prediction. Dive into each section for the full analysis of each play.
West Virginia vs Iowa State Preview
West Virginia goes up against Iowa State in this Week 5 matchup at Jack Trice Stadium, with kickoff scheduled for 12:00 on Saturday, October 3.
Big 12 positioning is already important as West Virginia and Iowa State meet during the Cyclones’ 113th Homecoming celebration. Both teams dropped their conference openers, putting added pressure on this matchup as the Mountaineers and Cyclones look to secure their first Big 12 victory of the season.
The West Virginia Mountaineers are 3-1 this season after suffering their first defeat in a 41-24 home loss to the Oklahoma State Cowboys. Running back Cam Cook rushed for 193 yards, while quarterback Michael Hawkins Jr. ran for three touchdowns. West Virginia finished with 467 total yards but was outscored 28-10 in the second half.
The Iowa State Cyclones are 2-2 after suffering a 31-17 home defeat to No. 15 Utah in their Big 12 opener. Quarterback Jaylen Raynor threw for 205 yards and a touchdown while adding a rushing score. Iowa State rallied from a 24-3 halftime deficit to pull within seven in the fourth quarter before Utah sealed the victory.
H2H: 4 Iowa State Wins in Last 5 H2H Matchups
Iowa State has won the last two meetings against West Virginia, most recently taking a 28-16 victory at Mountaineer Field after a 31-14 win at Jack Trice Stadium. The Cyclones have had the upper hand in recent years, winning five of the past six matchups.
Quarterbacks
Michael Hawkins Jr.
Jaylen Raynor
Best Bet
Bet on Iowa State against the spread, with an attractive line of -2.5 that the favorites get the job done. There are odds of -122 that are currently on offer for this college football matchup.
Key stats supporting our main match prediction:
Tracking injury updates is a big part of our CFB analysis and team news plays a major role in shaping our picks. We combine this with recent form and the most important stats to get a complete picture.
Iowa State -2.5 Probability
According to the top sportsbooks, our pick has a 54.9% chance of delivering a return. Based on our in-depth research, we calculate the actual probability to be closer to 60%. This college wager can therefore be backed with confidence.
If you want to back Iowa State without taking them on the point spread, there’s the alternative to go for a Winning Margin wager instead. There are lots of different options here.
Don’t place a bet without checking our guide full of top-tier betting offers, from free bets to welcome bonus incentives.
Same Game Parlay Pick
Our same game parlay pick is Iowa State -2.5 on the spread, Over 52.5 and the first score to be a Touchdown.
Should you want to back different outcomes for the same game, then a football same game parlay will suit your needs. The betting sites create this personalised wagering tool where you can make different picks and combine the odds together.
Correct Score Prediction
27
-
34
Iowa State
If you want to take a chance on a correct score, then the Cyclones to achieve a 34-27 win could be along the right lines. There are huge odds for this particular outcome.
West Virginia vs Iowa State Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
Iowa State have the shortest price to win this college game, with the sportsbooks giving them a 61% probability due to their -156 Moneyline betting odds. The market suggests that West Virginia are least likely to win at +130.
2.5 is the spread and 52.5 is the total points line. Having a bet on the Totals is one of the most popular football wagers. Those expecting a low total can back Under 52.5 at -104.
If you’re planning to place a college football wager, visit the best betting apps and check out the huge selection of available team props and game lines. Find the odds and betting lines which are the most attractive.
Receiving Yards
Rushing Yards
Passing Yards
Iowa State Have Taken Seven Wins From Last Ten Home Outings
Iowa State has a 7-3 record in their last 10 home games, averaging 33.30 points scored and 18.20 points allowed.
West Virginia has a 4-6 record in their last 10 games away from home, putting up 24.00 points on average and giving up 33.00.
Iowa State earned a 31-14 win over West Virginia the last time they played at Jack Trice Stadium.
| Last 10 Games | W-L | P | PF | PA | O52.5 | U52.5 | |
|---|---|---|---|---|---|---|---|
 Iowa State Home Stats |
7-3 | 51.50 | 33.30 | 18.20 | 4 | 6 | |
 West Virginia Away Stats |
4-6 | 57.00 | 24.00 | 33.00 | 7 | 3 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O52.5 = Games Over 52.5 Points
- U52.5 = Games Under 52.5 Points
Latest regular season and playoff games stats.
West Virginia Stats
Iowa State Cyclones Stats
- 5 wins and 5 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
- +2.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road
- -2.5 Betting Line: Have covered the spread in 5 of the last 10 games
- -2.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 57.00 pts in the previous 10 games
- Game Totals on the Road: An average of 57.00 pts in the previous 10 games on the road
- Over 52.5: Covered in 6 of the previous 10 games
- Over 52.5 on the Road: Covered in 7 of the previous 10 games on the road
- Team Totals: Have scored an average of 27.20 pts and allowed 29.80 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 24.00 pts and allowed 33.00 pts in the last 10 games on the road
- Game Totals: An average of 46.10 pts in the previous 10 games
- Game Totals at Home: An average of 51.50 pts in the previous 10 home games
- Over 52.5: Covered in 2 of the previous 10 games
- Over 52.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 26.40 pts and allowed 19.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 33.30 pts and allowed 18.20 pts in the last 10 home games
| Big 12 | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
BYU
|
4 | 0 | 149 | 57 | 92 | 2-0 | 2-0 | 4W |
Texas Tech
|
5 | 0 | 174 | 81 | 93 | 3-0 | 2-0 | 5W |
Baylor
|
4 | 1 | 174 | 71 | 103 | 3-0 | 1-1 | 4W |
Utah
|
4 | 0 | 173 | 41 | 132 | 3-0 | 1-0 | 4W |
Oklahoma State
|
3 | 1 | 149 | 79 | 70 | 2-0 | 1-1 | 3W |
Arizona
|
4 | 1 | 162 | 83 | 79 | 3-0 | 1-1 | 3W |
Cincinnati
|
4 | 1 | 169 | 116 | 53 | 4-0 | 0-1 | 1L |
Houston
|
4 | 1 | 205 | 99 | 106 | 3-0 | 1-1 | 2W |
|
Iowa State
|
3 | 2 | 168 | 106 | 62 | 3-1 | 0-1 | 1W |
UCF
|
3 | 2 | 162 | 88 | 74 | 3-0 | 0-2 | 1L |
Arizona State
|
2 | 2 | 133 | 127 | 6 | 1-1 | 1-1 | 1L |
Kansas State
|
3 | 1 | 162 | 61 | 101 | 3-0 | 0-1 | 1L |
|
West Virginia
|
3 | 2 | 187 | 144 | 43 | 2-1 | 1-1 | 2L |
Kansas
|
2 | 2 | 144 | 68 | 76 | 2-2 | 0-0 | 1W |
Colorado
|
2 | 3 | 93 | 127 | -34 | 1-1 | 1-2 | 3L |
TCU
|
2 | 3 | 127 | 67 | 60 | 2-2 | 0-1 | 2L |
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