Lions vs Bills Prediction, Picks & Odds | 17 Sep 2026

NFL Betting Preview: Lions vs Bills

The Detroit Lions square off against the Buffalo Bills in this Week 2 matchup at Highmark Stadium, with kickoff scheduled for 20:15 on Thursday, September 17.

54.5 points looks too big a number on the total line and we are happy to play the -115 about Under when the Bills and the Lions square off.

Detroit Lions opened the season with a 31-30 home win against New Orleans Saints at Ford Field in Week 1. The Lions totaled 369 yards, including 204 passing and 165 rushing yards. They picked up 26 first downs and scored three touchdowns.

Buffalo Bills also started the season with a win, beating Houston Texans 36-31 on the road at NRG Stadium. The Bills totaled 409 yards, including 323 passing and 86 rushing yards, with their offense picking up 20 first downs and four touchdowns.

Head-to-Head Statistics

The Bills triumphed 48-42 when they last played the Lions. This head-to-head was played at Ford Field.

Quarterbacks

Jared Goff

257.5 Passing Yards

Over -114

Under -114

Josh Allen

250.5 Passing Yards

Over -114

Under -114

Lions vs Bills Prediction & Picks

Get set for Lions vs Bills with our full betting breakdown, complete with an expert match prediction, a likely final score, top player prop picks and a value-driven bet builder.

Game Prediction

We’re not convinced these NFL opponents are cumulatively going to produce enough points in relation to the total line. Therefore, we’re aiming to go Under 54.5 at -115.

We keep a close eye on team news and our expert NFL handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Lions vs Bills stats:

• The 54.5 line hasn’t been covered in 12 of the last 20 Lions games on the road.
• The 54.5 line hasn’t been covered in 3 of the last 5 Lions games.
• The 54.5 line hasn’t been covered in the last 2 Lions games on the road.
• The 54.5 line hasn’t been covered in 7 of the last 10 Bills games at home.
• The 54.5 line hasn’t been covered in 14 of the last 20 Bills games.
• The 54.5 line hasn’t been covered in the last 2 Bills games at home.

Under 54.5 Probability

The best betting apps make it a 53.5% chance that our pick is settled as a winner. In our opinion, there’s actually a probability of success closer to 60%. It is therefore regarded as a value bet.

The bigger odds can be found if you combine your Under bet on the Totals with other picks in a Bet Builder. This is popular way of betting on multiple outcomes in a single game.

Make the most of your next wager by unlocking the best betting offers along with the latest sign-up bonuses and promotions.

Our Game Prediction

Under 54.5 Points @ -115 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 16, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Josh Allen Anytime TD -135

The odds for Josh Allen (Bills) to score a TD are -135. He looks like a value bet to punch it in and we recommend backing this Anytime Touchdown Scorer pick.

Latest Josh Allen Player Prop Odds

Touchdown

Anytime

-141

First

+650

Passing Yards

Over 250.5

-114

Under 250.5

-114

Rushing Yards

Over 31.5

-114

Under 31.5

-114

---

Amon-Ra St. Brown Under 79.5 Receiving Yards -114

The odds for Amon-Ra St. Brown (Bills) to record fewer than 79.5 receiving yards are -114. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the Player Receiving Yards line.

Latest Amon-Ra St. Brown Player Prop Odds

Touchdown

Anytime

+105

First

+1000

Receiving Yards

Over 79.5

-114

Under 79.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Lions 21 - 31 Bills

Let’s roll the dice and try the Bills to enjoy a 31-21 winning scoreline here. There are massive odds for this potential outcome and it’s a fun type of wager to enjoy.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Lions vs Bills Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Buffalo has the shortest price to win this game, with the sportsbooks giving the Bills a 70% probability due to their -238 Moneyline betting odds. If you’re looking for an alternative angle, Detroit is trading at +198.

The current spread is 5.5 and total points is 54.5. Having a wager on the Totals is one of the most popular NFL bets. If you fancy Under 54.5, then the odds are -105.

Whether you're placing bets before kickoff or during the game, the best NFL sportsbooks delivers a massive range of game lines and team props. The betting sites give you endless ways to get involved with plenty of exciting alternatives.

Moneyline

Lions

+198

Bills

-238

Point Spread

Lions +5.5

-115

Bills -5.5

-105

Total Points

Under 54.5

-105

Over 54.5

-115

There is -278 available that Jahmyr Gibbs scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +410.

Touchdown

Jahmyr Gibbs (Lions)

First TD

+410

Anytime TD

-278

James Cook (Bills)

First TD

+500

Anytime TD

-169

Josh Allen (Bills)

First TD

+650

Anytime TD

-141

Amon-Ra St. Brown (Lions)

First TD

+1000

Anytime TD

+105

DJ Moore (Bills)

First TD

+1200

Anytime TD

+150

Dalton Kincaid (Bills)

First TD

+1200

Anytime TD

+170

Jameson Williams (Lions)

First TD

+1500

Anytime TD

+190

Khalil Shakir (Bills)

First TD

+1600

Anytime TD

+220

Sam LaPorta (Lions)

First TD

+1700

Anytime TD

+220

Ty Johnson (Bills)

First TD

+2200

Anytime TD

+320

Keon Coleman (Bills)

First TD

+2500

Anytime TD

+420

Isaac TeSlaa (Lions)

First TD

+3000

Anytime TD

+500

Dawson Knox (Bills)

First TD

+3000

Anytime TD

+500

Joshua Palmer (Bills)

First TD

+3000

Anytime TD

+550

Ray Davis (Bills)

First TD

+4000

Anytime TD

+650

Jackson Hawes (Bills)

First TD

+4000

Anytime TD

+700

Brock Wright (Lions)

First TD

+5500

Anytime TD

+1000

Sione Vaki (Lions)

First TD

+5500

Anytime TD

+800

Franklin Gore Jr. (Bills)

First TD

+7000

Anytime TD

+1100

Greg Dortch (Bills)

First TD

+8000

Anytime TD

+1300

Jared Goff (Lions)

First TD

+10000

Anytime TD

+2200

Jacob Saylors (Lions)

First TD

+10000

Anytime TD

+2200

Tyler Conklin (Lions)

First TD

+10000

Anytime TD

+1800

Keleki Latu (Bills)

First TD

+10000

Anytime TD

+2200

Tom Kennedy (Lions)

First TD

+10000

Anytime TD

+2000

Tay Martin (Lions)

First TD

+10000

Anytime TD

+6500

Jackson Meeks (Lions)

First TD

+10000

Anytime TD

+6500

Skyler Bell (Bills)

First TD

+10000

Anytime TD

+2500

Receiving Yards

Amon-Ra St. Brown (Lions)

Over 79.5

-114

Under 79.5

-114

DJ Moore (Bills)

Over 63.5

-114

Under 63.5

-114

Jameson Williams (Lions)

Over 57.5

-114

Under 57.5

-114

Dalton Kincaid (Bills)

Over 52.5

-114

Under 52.5

-114

Sam LaPorta (Lions)

Over 46.5

-114

Under 46.5

-114

Khalil Shakir (Bills)

Over 43.5

-114

Under 43.5

-114

Jahmyr Gibbs (Lions)

Over 30.5

-114

Under 30.5

-114

James Cook (Bills)

Over 18.5

-114

Under 18.5

-114

Isaac TeSlaa (Lions)

Over 17.5

-114

Under 17.5

-114

Keon Coleman (Bills)

Over 14.5

-114

Under 14.5

-114

Dawson Knox (Bills)

Over 12.5

-114

Under 12.5

-114

Joshua Palmer (Bills)

Over 10.5

-114

Under 10.5

-114

Brock Wright (Lions)

Over 6.5

-114

Under 6.5

-114

Rushing Yards

Jahmyr Gibbs (Lions)

Over 87.5

-114

Under 87.5

-114

James Cook (Bills)

Over 78.5

-114

Under 78.5

-114

Josh Allen (Bills)

Over 31.5

-114

Under 31.5

-114

Ray Davis (Bills)

Over 8.5

-114

Under 8.5

-114

Sione Vaki (Lions)

Over 5.5

+108

Under 5.5

-139

Jared Goff (Lions)

Over 0.5

+124

Under 0.5

-159

Passing Yards

Jared Goff (Lions)

Over 257.5

-114

Under 257.5

-114

Josh Allen (Bills)

Over 250.5

-114

Under 250.5

-114

There are always opportunities to enjoy NFL micro betting. It’s generally the case that you will find team and player props in-game and bettors can use their insight to wager on outcomes such as the Next Punt, Turnover or Score Play.

Bills Count Eight Wins in Previous Ten at Home

The Bills have gone 8-2 across their last 10 home games, posting 30.80 points per contest while yielding 23.60.

The Lions have a 5-5 record in their last 10 games away from home, posting 26.10 points per contest while yielding 26.30.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Bills Home Stats		8-2	54.40	30.80	23.60	3	7
Lions Away Stats		5-5	52.40	26.10	26.30	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Latest regular season and playoff games stats.

Detroit Lions Stats

Buffalo Bills Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +4.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +4.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -4.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -4.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 53.80 pts in the previous 10 games
• Game Totals on the Road: An average of 52.40 pts in the previous 10 games on the road
• Over 54.5: Covered in 6 of the previous 10 games
• Over 54.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.30 pts and allowed 26.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.10 pts and allowed 26.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.60 pts in the previous 10 games
• Game Totals at Home: An average of 54.40 pts in the previous 10 home games
• Over 54.5: Covered in 4 of the previous 10 games
• Over 54.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 28.20 pts and allowed 22.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.80 pts and allowed 23.60 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 390.70 Yds. Allowed 375.30 Yds
• Rushing Yards: Gained 120.50 Yds. Allowed 128.20 Yds
• Passing Yards: Gained 270.20 Yds. Allowed 247.10 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 21.80. Allowed 20.70
• Total Turnovers: Committed 1.00. Committed by opponents 1.00
• Total Penalties: Committed 6.00. Committed by opponents 5.70
• Penalty Yards: Lost 38.80 Yds. Gained 48.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 372.10 Yds. Allowed 284.50 Yds
• Rushing Yards: Gained 158.60 Yds. Allowed 113.30 Yds
• Passing Yards: Gained 213.50 Yds. Allowed 171.20 Yds
• Total Touchdowns: Scored 3.50 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 21.80. Allowed 17.90
• Total Turnovers: Committed 1.30. Committed by opponents 1.20
• Total Penalties: Committed 5.60. Committed by opponents 4.50
• Penalty Yards: Lost 47.70 Yds. Gained 44.50 Yds

Last 10 Games on the Road

• Total Yards: Gained 369.60 Yds. Allowed 324.60 Yds
• Rushing Yards: Gained 119.80 Yds. Allowed 105.80 Yds
• Passing Yards: Gained 249.80 Yds. Allowed 218.80 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 2.00 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 21.00. Allowed 19.80
• Total Turnovers: Committed 1.00. Committed by opponents 0.80
• Total Penalties: Committed 5.60. Committed by opponents 4.40
• Penalty Yards: Lost 39.30 Yds. Gained 30.20 Yds

Last 10 Home Games

• Total Yards: Gained 388.40 Yds. Allowed 308.30 Yds
• Rushing Yards: Gained 144.70 Yds. Allowed 129.80 Yds
• Passing Yards: Gained 243.70 Yds. Allowed 178.50 Yds
• Total Touchdowns: Scored 4.00 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 2.00 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 23.10. Allowed 18.60
• Total Turnovers: Committed 0.90. Committed by opponents 1.20
• Total Penalties: Committed 5.60. Committed by opponents 4.60
• Penalty Yards: Lost 44.90 Yds. Gained 43.30 Yds

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