Lions vs Chiefs Prediction, Picks & Odds | 12 Oct 2025

NFL Betting Preview: Lions vs Chiefs

The Detroit Lions clash with the Kansas City Chiefs in this NFL Week 6 matchup at GEHA Field at Arrowhead Stadium, with kickoff scheduled for 20:20 on Sunday, October 12. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We are happy to get with the Lions against the spread. -110 is available that they are able to cover +2.5 against the Chiefs and that looks very reasonable.

Detroit Lions have won four on the spin, triumphing 37-24 in their previous game. This was on the road against Cincinnati Bengals at Paycor Stadium. The Lions totaled 365 yards, with 247 through the air and 118 on the ground. The offense converted for 23 first downs along with 5 touchdowns.

Kansas City Chiefs were beaten last game and this was on the road at GEHA Field at Arrowhead Stadium. Jacksonville Jaguars claimed a 31-28 win. The Chiefs recorded 476 yards, split between 318 passing and 158 rushing yards. The offense generated 26 first downs and produced 4 touchdowns.

Head-to-Head Statistics

The Lions triumphed 21-20 when they last played the Chiefs. This head-to-head was played at GEHA Field at Arrowhead Stadium.

Quarterbacks

Jared Goff

241.5 Passing Yards

Over -112

Under -112

Patrick Mahomes

262.5 Passing Yards

Over -112

Under -112

Lions vs Chiefs Prediction & Picks

Discover the top Lions vs Chiefs betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.

Game Prediction

We wouldn’t be surprised to see the Lions triumph in this NFL battle. In terms of landing extra value, it makes sense to take +2.5 on the spread at -110.

Tracking injury updates is a big part of our analysis and team news plays a major role in shaping our NFL predictions. We combine this with recent form and the most important stats to get a complete picture.

Key Lions vs Chiefs stats:

• The +2.5 line has been covered by Lions in 4 consecutive games.
• The +2.5 line has been covered by Lions in 9 of their last 10 games on the road.
• The +2.5 line has been covered by Lions in 17 of their last 20 games.
• The -2.5 line hasn’t been covered by Chiefs in 3 of their last 5 games this season.

Lions +2.5 Probability

The best sportsbooks are estimating that there is a 52.4% likelihood of this pick winning. Taking all factors into consideration, our analysts think there’s a stronger chance of success and have a probability interval between 55-60%. The wager can be recommended for this precise reason.

It’s possible to move the line for your spread pick and this allows bettors to get increasingly bigger odds. Squeeze more juice from your selection by taking an alternative view.

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Our Game Prediction

Lions +2.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 11, 02:26). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Jameson Williams Anytime TD +210

You can place a bet on Jameson Williams (Lions) to score a TD at +210. We’ll have a play on this Anytime Touchdown Scorer bet, which could hopefully result in him taking it to the house.

Latest Jameson Williams Player Prop Odds

Touchdown

Anytime

+210

First

+1500

Receiving Yards

Over 45.5

-112

Under 45.5

-112

Rushing Yards

Over 1.5

+122

Under 1.5

-154

---

Jared Goff Over 239.5 Passing Yards -114

The odds for Jared Goff (Lions) to record more than 239.5 passing yards are -114. We can back him in the QB Passing Yards market and hope the Over hits.

Latest Jared Goff Player Prop Odds

Touchdown

Anytime

+1800

First

+10000

Passing Yards

Over 241.5

-112

Under 241.5

-112

Rushing Yards

Over 0.5

-127

Under 0.5

-102

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Lions 31 - 28 Chiefs

There might not be too much between these teams, with our correct score prediction being a 31-28 win for the Lions. There are enormous odds available when it comes to this pick.

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Lions vs Chiefs Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks’ betting odds have Kansas City Chiefs as -154 favorites for this game, implying that they are 61% likely to win. For those wanting to oppose the market leader, you can get +130 about Detroit Lions.

There is a spread of 3 and total points has a line of 48.5. A Total bet is always available and can often provide value selections. If you fancy Under 48.5, then the odds are -110.

If you're betting on the matchups, it's worth checking out the best NFL sportsbooks, where you'll find a massive range of game lines and team props. You can place your bets before kickoff or while the action is underway.

Moneyline

Lions

+130

Chiefs

-154

Point Spread

Lions +3

-115

Chiefs -3

-105

Total Points

Under 48.5

-110

Over 48.5

-110

Jahmyr Gibbs is priced at +550 when it comes to First TD Scorer. He’s the favorite and also available at odds of -149 to score a touchdown at anytime.

Touchdown

Jahmyr Gibbs (Lions)

First TD

+550

Anytime TD

-149

David Montgomery (Lions)

First TD

+750

Anytime TD

+105

Amon-Ra St. Brown (Lions)

First TD

+850

Anytime TD

+110

Xavier Worthy (Chiefs)

First TD

+1000

Anytime TD

+145

Travis Kelce (Chiefs)

First TD

+1000

Anytime TD

+150

Kareem Hunt (Chiefs)

First TD

+1100

Anytime TD

+150

Isiah Pacheco (Chiefs)

First TD

+1400

Anytime TD

+220

Jameson Williams (Lions)

First TD

+1500

Anytime TD

+210

Sam LaPorta (Lions)

First TD

+1500

Anytime TD

+230

Patrick Mahomes (Chiefs)

First TD

+1600

Anytime TD

+290

Marquise Brown (Chiefs)

First TD

+1700

Anytime TD

+280

JuJu Smith-Schuster (Chiefs)

First TD

+1900

Anytime TD

+300

Tyquan Thornton (Chiefs)

First TD

+2000

Anytime TD

+310

Brashard Smith (Chiefs)

First TD

+2700

Anytime TD

+490

Noah Gray (Chiefs)

First TD

+3500

Anytime TD

+650

Isaac TeSlaa (Lions)

First TD

+5000

Anytime TD

+950

Kalif Raymond (Lions)

First TD

+8000

Anytime TD

+900

Sione Vaki (Lions)

First TD

+10000

Anytime TD

+2700

Brock Wright (Lions)

First TD

+10000

Anytime TD

+1200

Jared Goff (Lions)

First TD

+10000

Anytime TD

+1800

Jason Brownlee (Chiefs)

First TD

+10000

Anytime TD

+3300

Jalen Royals (Chiefs)

First TD

+10000

Anytime TD

+2700

Robert Tonyan (Chiefs)

First TD

+10000

Anytime TD

+2700

Dominic Lovett (Lions)

First TD

+10000

Anytime TD

+3000

Jared Wiley (Chiefs)

First TD

+10000

Anytime TD

+2200

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+3500

Ross Dwelley (Lions)

First TD

+10000

Anytime TD

+3500

Jacob Saylors (Lions)

First TD

+10000

Anytime TD

+4000

Craig Reynolds (Lions)

First TD

+10000

Anytime TD

+2700

Receiving Yards

Amon-Ra St. Brown (Lions)

Over 74.5

-112

Under 74.5

-112

Xavier Worthy (Chiefs)

Over 62.5

-112

Under 62.5

-112

Jameson Williams (Lions)

Over 45.5

-112

Under 45.5

-112

Sam LaPorta (Lions)

Over 44.5

-112

Under 44.5

-112

Travis Kelce (Chiefs)

Over 42.5

-112

Under 42.5

-112

Marquise Brown (Chiefs)

Over 39.5

-112

Under 39.5

-112

Jahmyr Gibbs (Lions)

Over 28.5

-112

Under 28.5

-112

Tyquan Thornton (Chiefs)

Over 27.5

-112

Under 27.5

-112

JuJu Smith-Schuster (Chiefs)

Over 23.5

-112

Under 23.5

-112

Noah Gray (Chiefs)

Over 11.5

-112

Under 11.5

-112

Brashard Smith (Chiefs)

Over 11.5

-112

Under 11.5

-112

Isiah Pacheco (Chiefs)

Over 9.5

-112

Under 9.5

-112

Isaac TeSlaa (Lions)

Over 9.5

-112

Under 9.5

-112

David Montgomery (Lions)

Over 7.5

-112

Under 7.5

-112

Rushing Yards

Jahmyr Gibbs (Lions)

Over 65.5

-112

Under 65.5

-112

David Montgomery (Lions)

Over 41.5

-112

Under 41.5

-112

Kareem Hunt (Chiefs)

Over 29.5

-112

Under 29.5

-112

Isiah Pacheco (Chiefs)

Over 29.5

-112

Under 29.5

-112

Patrick Mahomes (Chiefs)

Over 26.5

-112

Under 26.5

-112

Xavier Worthy (Chiefs)

Over 4.5

-110

Under 4.5

-116

Jameson Williams (Lions)

Over 1.5

+122

Under 1.5

-154

Jared Goff (Lions)

Over 0.5

-127

Under 0.5

-102

Passing Yards

Patrick Mahomes (Chiefs)

Over 262.5

-112

Under 262.5

-112

Jared Goff (Lions)

Over 241.5

-112

Under 241.5

-112

It’s good to consider all wagering options when it comes to NFL and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Chiefs Count Nine Wins in Previous Ten at Home

The Chiefs are 9-1 in their last 10 home games, putting up 24.60 points on average and giving up 18.70.

The Lions are 9-1 in their last 10 games on the road, putting up 31.40 points on average and giving up 21.30.

The Lions earned a 24-23 win over the Chiefs the last time they played at GEHA Field at Arrowhead Stadium.

Last 10 Games		W-L	P	PF	PA	O52.5	U52.5
Chiefs Home Stats		9-1	43.30	24.60	18.70	3	7
Lions Away Stats		9-1	52.70	31.40	21.30	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O52.5 = Games Over 52.5 Points
• U52.5 = Games Under 52.5 Points

Latest regular season and playoff games stats.

Detroit Lions Stats

Kansas City Chiefs Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 61.70 pts in the previous 10 games
• Game Totals on the Road: An average of 52.70 pts in the previous 10 games on the road
• Over 52.5: Covered in 6 of the previous 10 games
• Over 52.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 35.20 pts and allowed 26.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 31.40 pts and allowed 21.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.90 pts in the previous 10 games
• Game Totals at Home: An average of 43.30 pts in the previous 10 home games
• Over 52.5: Covered in 4 of the previous 10 games
• Over 52.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 23.10 pts and allowed 23.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.60 pts and allowed 18.70 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 417.50 Yds. Allowed 365.30 Yds
• Rushing Yards: Gained 139.90 Yds. Allowed 109.40 Yds
• Passing Yards: Gained 277.60 Yds. Allowed 255.90 Yds
• Total Touchdowns: Scored 4.50 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 1.70 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 2.60 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 23.80. Allowed 20.80
• Total Turnovers: Committed 1.10. Committed by opponents 1.30
• Total Penalties: Committed 6.30. Committed by opponents 5.80
• Penalty Yards: Lost 45.90 Yds. Gained 37.80 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 314.70 Yds. Allowed 346.80 Yds
• Rushing Yards: Gained 93.00 Yds. Allowed 140.80 Yds
• Passing Yards: Gained 221.70 Yds. Allowed 206.00 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 18.60. Allowed 20.90
• Total Turnovers: Committed 0.60. Committed by opponents 0.90
• Total Penalties: Committed 7.00. Committed by opponents 6.00
• Penalty Yards: Lost 58.00 Yds. Gained 44.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 383.00 Yds. Allowed 332.40 Yds
• Rushing Yards: Gained 138.00 Yds. Allowed 86.40 Yds
• Passing Yards: Gained 245.00 Yds. Allowed 246.00 Yds
• Total Touchdowns: Scored 3.90 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.60 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 2.00 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 22.10. Allowed 18.30
• Total Turnovers: Committed 0.80. Committed by opponents 1.70
• Total Penalties: Committed 6.60. Committed by opponents 6.40
• Penalty Yards: Lost 54.50 Yds. Gained 44.10 Yds

Last 10 Home Games

• Total Yards: Gained 340.20 Yds. Allowed 308.30 Yds
• Rushing Yards: Gained 102.70 Yds. Allowed 109.70 Yds
• Passing Yards: Gained 237.50 Yds. Allowed 198.60 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 22.10. Allowed 18.10
• Total Turnovers: Committed 0.40. Committed by opponents 0.60
• Total Penalties: Committed 4.90. Committed by opponents 6.50
• Penalty Yards: Lost 38.80 Yds. Gained 58.50 Yds

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