Colts vs Chiefs Prediction, Picks & Odds | 20 Sep 2026

NFL Betting Preview: Colts vs Chiefs

The Indianapolis Colts face the Kansas City Chiefs at GEHA Field at Arrowhead Stadium, with kickoff scheduled for 20:20 on Sunday, September 20.

Under 46.5 could be on the money for this Chiefs vs Colts clash. Our prediction is based on a low-scoring game and the odds of -110 looks like a value bet.

Sunday Night Football puts Patrick Mahomes back on the national stage as Kansas City continues a season built around renewed championship expectations. Indianapolis faces a demanding road test against a Chiefs offense now featuring Kenneth Walker III, while Jonathan Taylor gives the Colts a proven centerpiece capable of testing Kansas City’s defense.

Indianapolis Colts opened their campaign with a 41-23 home defeat against Baltimore Ravens at Lucas Oil Stadium. Indianapolis finished with 251 total yards, including 149 net passing yards and 102 on the ground, while recording 17 first downs and scoring three touchdowns.

Jonathan Taylor provided the biggest offensive contribution, rushing for 98 yards and two touchdowns on 16 carries. Daniel Jones completed 19 of 31 passes for 163 yards and a touchdown but was intercepted once, with Tyler Warren catching the Colts' only passing score.

Kansas City Chiefs launched their season with a 31-10 home win against Denver Broncos at GEHA Field at Arrowhead Stadium. Kansas City generated 392 total yards, including 172 net passing yards and 220 rushing yards, while recording 19 first downs and scoring four touchdowns.

Kenneth Walker III delivered a huge performance on his Chiefs debut, rushing for a career-high 173 yards and a touchdown on 22 carries while adding 18 receiving yards and another score. Patrick Mahomes returned to action by throwing for 184 yards and two touchdowns and rushing for 23 yards and a score.

Head-to-Head Statistics

The last head-to-head saw the Chiefs claim a 23-20 (OT) win over the Colts at GEHA Field at Arrowhead Stadium. Both teams have two wins on the board when we look at the 4-game H2H record.

Quarterbacks

Daniel Jones

218.5 Passing Yards

Over -114

Under -114

Patrick Mahomes

221.5 Passing Yards

Over -114

Under -114

Colts vs Chiefs Prediction & Picks

Approach Colts vs Chiefs fully prepared with our expert match prediction, likely score outcome, standout player prop picks and a hand-picked bet builder.

Game Prediction

The Unders looks the way to go for this NFL matchup. The line looks too high at 46.5 and odds of -110 could favor bettors who go below that total.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Colts vs Chiefs stats:

• The 46.5 line hasn’t been covered in the last 7 Chiefs games at home.
• The 46.5 line hasn’t been covered in 8 of the last 10 Chiefs games.
• The 46.5 line hasn’t been covered in 14 of the last 20 Chiefs games at home.
• The 46.5 line hasn’t been covered in the last 4 games between these teams.

Under 46.5 Probability

The top NFL sportsbooks make it a 52.4% chance that our pick is settled as a winner. However, our cappers have this figure between 55-60% based on their in-depth research. This is why we can recommend this bet.

The bigger odds can be found if you combine your Under bet on the Totals with other picks in a Bet Builder. This is popular way of betting on multiple outcomes in a single game.

Check out the most rewarding betting offers in our in-depth guide before your next wager. The best bonuses and free bets await.

Our Game Prediction

Under 46.5 Points @ -110 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 19, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Patrick Mahomes Under 221.5 Passing Yards -114

Patrick Mahomes (Chiefs) can be backed at -114 to end with fewer than 221.5 passing yards. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.

Latest Patrick Mahomes Player Prop Odds

Touchdown

Anytime

+330

First

+1700

Passing Yards

Over 221.5

-114

Under 221.5

-114

Rushing Yards

Over 17.5

-114

Under 17.5

-114

---

Travis Kelce Anytime TD +180

Travis Kelce (Chiefs) can be backed at +180 to hit the end zone. We think this is the pick of the player props, with generous odds available when it comes to backing him to score a touchdown at any time.

Latest Travis Kelce Player Prop Odds

Touchdown

Anytime

+185

First

+1100

Receiving Yards

Over 41.5

-114

Under 41.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Colts 17 - 27 Chiefs

The Chiefs might get the upper hand and it might be worth backing them to achieve a specific correct score. Try an outcome of 27-17 for a big possible return from your stake.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Colts vs Chiefs Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a 75% chance of securing victory, Kansas City Chiefs are favorites for this game and the sportsbooks have them at betting odds of -294. At +235, Indianapolis Colts are regarded as having a lower probability of winning.

There is a spread of 6.5 and total points has a line of 45.5. There is no denying the popularity of betting on the Totals. Those that want to back Under 45.5 can find odds of -105 available.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Moneyline

Colts

+235

Chiefs

-294

Point Spread

Colts +6.5

-120

Chiefs -6.5

-102

Total Points

Under 45.5

-105

Over 45.5

-115

Kenneth Walker III is the market leader to be First TD Scorer at +360. Alternatively, there’s the chance to back him to register a touchdown at any stage at -208.

Touchdown

Kenneth Walker III (Chiefs)

First TD

+360

Anytime TD

-208

Jonathan Taylor (Colts)

First TD

+450

Anytime TD

-145

Rashee Rice (Chiefs)

First TD

+850

Anytime TD

+140

Travis Kelce (Chiefs)

First TD

+1100

Anytime TD

+185

Xavier Worthy (Chiefs)

First TD

+1300

Anytime TD

+240

Alec Pierce (Colts)

First TD

+1500

Anytime TD

+270

Tyler Warren (Colts)

First TD

+1600

Anytime TD

+250

Patrick Mahomes (Chiefs)

First TD

+1700

Anytime TD

+330

Josh Downs (Colts)

First TD

+2000

Anytime TD

+390

Keenan Allen (Colts)

First TD

+2200

Anytime TD

+400

Emmett Johnson (Chiefs)

First TD

+2500

Anytime TD

+500

Daniel Jones (Colts)

First TD

+2700

Anytime TD

+550

Tyquan Thornton (Chiefs)

First TD

+2700

Anytime TD

+550

Noah Gray (Chiefs)

First TD

+3000

Anytime TD

+700

Jared Wiley (Chiefs)

First TD

+4000

Anytime TD

+1000

Mo Alie-Cox (Colts)

First TD

+4500

Anytime TD

+950

DJ Giddens (Colts)

First TD

+5500

Anytime TD

+1100

Ashton Dulin (Colts)

First TD

+6000

Anytime TD

+1200

Seth McGowan (Colts)

First TD

+6000

Anytime TD

+1200

Jake Briningstool (Chiefs)

First TD

+6000

Anytime TD

+1500

Laquon Treadwell (Colts)

First TD

+8000

Anytime TD

+1600

Cyrus Allen (Chiefs)

First TD

+8000

Anytime TD

+2200

Jalen Royals (Chiefs)

First TD

+8000

Anytime TD

+2200

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+2200

Brashard Smith (Chiefs)

First TD

+10000

Anytime TD

+2200

Drew Ogletree (Colts)

First TD

+10000

Anytime TD

+3000

Deion Burks (Colts)

First TD

+10000

Anytime TD

+5000

Ben VanSumeren (Chiefs)

First TD

+10000

Anytime TD

+6000

Anthony Gould (Colts)

First TD

+10000

Anytime TD

+3000

Receiving Yards

Rashee Rice (Chiefs)

Over 48.5

-114

Under 48.5

-114

Alec Pierce (Colts)

Over 44.5

-114

Under 44.5

-114

Tyler Warren (Colts)

Over 42.5

-114

Under 42.5

-114

Travis Kelce (Chiefs)

Over 41.5

-114

Under 41.5

-114

Josh Downs (Colts)

Over 39.5

-114

Under 39.5

-114

Xavier Worthy (Chiefs)

Over 37.5

-114

Under 37.5

-114

Keenan Allen (Colts)

Over 29.5

-114

Under 29.5

-114

Kenneth Walker III (Chiefs)

Over 20.5

-114

Under 20.5

-114

Jonathan Taylor (Colts)

Over 16.5

-114

Under 16.5

-114

Tyquan Thornton (Chiefs)

Over 15.5

-114

Under 15.5

-114

Noah Gray (Chiefs)

Over 11.5

-114

Under 11.5

-114

Emmett Johnson (Chiefs)

Over 7.5

-114

Under 7.5

-114

Rushing Yards

Kenneth Walker III (Chiefs)

Over 82.5

-114

Under 82.5

-114

Jonathan Taylor (Colts)

Over 79.5

-114

Under 79.5

-114

Patrick Mahomes (Chiefs)

Over 17.5

-114

Under 17.5

-114

Emmett Johnson (Chiefs)

Over 17.5

-114

Under 17.5

-114

Daniel Jones (Colts)

Over 8.5

-114

Under 8.5

-114

Passing Yards

Patrick Mahomes (Chiefs)

Over 221.5

-114

Under 221.5

-114

Daniel Jones (Colts)

Over 218.5

-114

Under 218.5

-114

It’s good to consider all wagering options when it comes to NFL and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Chiefs Standing on Six Wins From Last Ten Home Matches

The Chiefs are 6-4 in their last 10 home games, posting 23.30 points per contest while yielding 15.00.

The Colts have been beaten five straight times on the road. They have a 2-8 record in their last 10 games away from home, putting up 25.00 points on average and giving up 28.90.

In their most recent matchup at GEHA Field at Arrowhead Stadium, the Chiefs got the better of the Colts 23-20. Looking at the last 3 head-to-heads at GEHA Field at Arrowhead Stadium, the Chiefs have tallied two victories, with the Colts winning once.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Chiefs Home Stats		6-4	38.30	23.30	15.00	2	8
Colts Away Stats		2-8	53.90	25.00	28.90	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Kansas City Chiefs Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 51.80 pts in the previous 10 games
• Game Totals on the Road: An average of 53.90 pts in the previous 10 games on the road
• Over 46.5: Covered in 6 of the previous 10 games
• Over 46.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.90 pts and allowed 29.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.00 pts and allowed 28.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 38.60 pts in the previous 10 games
• Game Totals at Home: An average of 38.30 pts in the previous 10 home games
• Over 46.5: Covered in 2 of the previous 10 games
• Over 46.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 17.90 pts and allowed 20.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 23.30 pts and allowed 15.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 304.40 Yds. Allowed 369.20 Yds
• Rushing Yards: Gained 102.90 Yds. Allowed 118.90 Yds
• Passing Yards: Gained 201.50 Yds. Allowed 250.30 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 18.30. Allowed 22.30
• Total Turnovers: Committed 2.10. Committed by opponents 1.00
• Total Penalties: Committed 5.80. Committed by opponents 6.50
• Penalty Yards: Lost 48.40 Yds. Gained 57.50 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 281.70 Yds. Allowed 308.00 Yds
• Rushing Yards: Gained 102.00 Yds. Allowed 105.80 Yds
• Passing Yards: Gained 179.70 Yds. Allowed 202.20 Yds
• Total Touchdowns: Scored 1.60 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 0.50 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 16.70. Allowed 16.90
• Total Turnovers: Committed 1.20. Committed by opponents 0.70
• Total Penalties: Committed 7.00. Committed by opponents 7.10
• Penalty Yards: Lost 52.80 Yds. Gained 55.80 Yds

Last 10 Games on the Road

• Total Yards: Gained 333.20 Yds. Allowed 349.30 Yds
• Rushing Yards: Gained 100.80 Yds. Allowed 86.70 Yds
• Passing Yards: Gained 232.40 Yds. Allowed 262.60 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 19.50. Allowed 20.30
• Total Turnovers: Committed 2.40. Committed by opponents 1.10
• Total Penalties: Committed 6.00. Committed by opponents 6.90
• Penalty Yards: Lost 51.90 Yds. Gained 59.60 Yds

Last 10 Home Games

• Total Yards: Gained 343.50 Yds. Allowed 252.50 Yds
• Rushing Yards: Gained 127.60 Yds. Allowed 91.00 Yds
• Passing Yards: Gained 215.90 Yds. Allowed 161.50 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 1.50 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 21.70. Allowed 14.20
• Total Turnovers: Committed 1.10. Committed by opponents 0.90
• Total Penalties: Committed 5.50. Committed by opponents 6.30
• Penalty Yards: Lost 42.90 Yds. Gained 53.60 Yds

Where to Bet on American Football Games

Top American Football Pages