Giants vs Rams Prediction, Picks & Odds | 21 Sep 2026

NFL Betting Preview: Giants vs Rams

The New York Giants go up against the Los Angeles Rams at SoFi Stadium, with kickoff scheduled for 20:15 on Monday, September 21.

The Rams and the Giants should be able to accumulate enough points for our pick to win. We’re predicting Over 47.5 and odds of -115 are available for this outcome.

Monday Night Football gets a major storyline as Aaron Donald returns from retirement for a star-loaded Rams team trying to live up to enormous expectations. The Giants bring their own intrigue under new coach John Harbaugh, while Jaxson Dart gets another prime-time stage against a Los Angeles defense built for a championship push.

New York Giants kicked off the John Harbaugh era with a 28-20 home win against Dallas Cowboys at MetLife Stadium. New York generated 394 total yards, including 229 net passing yards and 165 on the ground, while recording 29 first downs and scoring four touchdowns.

Jaxson Dart completed 23 of 29 passes for 230 yards and three touchdowns without an interception, while adding 54 rushing yards. Isaiah Likely caught eight passes for 78 yards and two touchdowns, while Cam Skattebo rushed for 81 yards and a score as the Giants opened with an NFC East victory.

Los Angeles Rams began their campaign with a 27-7 defeat against San Francisco 49ers at the Melbourne Cricket Ground in the NFL's first regular-season game in Australia. Los Angeles finished with 290 total yards, including 168 net passing yards and 122 rushing yards, while recording 15 first downs and scoring one touchdown.

Matthew Stafford completed 15 of 25 passes for 155 yards with no touchdowns and one interception as the Rams struggled to generate points. Puka Nacua provided their biggest receiving threat with five catches for 74 yards, while Kyren Williams scored Los Angeles' only touchdown on a five-yard run.

Head-to-Head Statistics

The Rams won the last matchup between the pair. Enjoying a 26-25 triumph when facing the Giants at MetLife Stadium. In the previous 3 H2H meetings, the Rams have won every time.

Quarterbacks

Jaxson Dart

213.5 Passing Yards

Over -114

Under -114

Matthew Stafford

238.5 Passing Yards

Over -114

Under -114

Giants vs Rams Prediction & Picks

From our key match prediction to correct score pick, top player prop insights and a builder tailored for value — our Giants vs Rams betting tips covers it all.

Game Prediction

Let’s go for Over 47.5 when these NFL teams lock horns. We think the line is too generous and we’re expecting the final total to be higher at -115.

The NFL handicappers at Sportsgambler.com regularly track injury updates and pair that with current form. We also tap into a deep stats database to highlight the key numbers that help shape our predictions.

Key Giants vs Rams stats:

• The 47.5 line has been covered in 3 of the last 5 Giants games.
• The 47.5 line has been covered in 6 of the last 10 Giants games.
• The 47.5 line has been covered in the last 2 Giants games.
• The 47.5 line has been covered in 8 of the last 10 Rams games.
• The 47.5 line has been covered in 12 of the last 20 Rams games.
• The 47.5 line has been covered in the last 2 games between these teams.

Over 47.5 Probability

According to the latest betting odds, our pick has a 53.5% chance of winning. However, our cappers research has found that the actual probability is closer to 60%. It is therefore regarded as a value bet.

There are ways to boost the odds on an Over pick and some bettors go down the Bet Builder route. It’s effectively a same game parlay where you throw in other selections.

Give yourself a head start. Explore the latest free bet promotions and bonus offers in our comprehensive guide.

Our Game Prediction

Over 47.5 Points @ -115 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 20, 02:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Matthew Stafford Over 242.5 Passing Yards -114

Matthew Stafford (Rams) is available at -114 to reach over 242.5 passing yards. With confidence, we can back him to cover the generous QB Passing Yards line, as all the signs point to him reaching the expected total.

Latest Matthew Stafford Player Prop Odds

Touchdown

Anytime

+2200

First

+10000

Passing Yards

Over 238.5

-114

Under 238.5

-114

Rushing Yards

Over 0.5

+172

Under 0.5

-227

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Isaiah Likely Over 43.5 Receiving Yards -114

You can back Isaiah Likely (Giants) at -114 to reach over 43.5 receiving yards. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.

Latest Isaiah Likely Player Prop Odds

Touchdown

Anytime

+290

First

+1800

Receiving Yards

Over 44.5

-114

Under 44.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Giants 24 - 28 Rams

For a fun wager, consider backing the Rams to claim a 28-24 victory. Although it’s a speculative bet, we are expecting things to be close between the two teams.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Giants vs Rams Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this game, the sportsbooks’ Moneyline betting odds mean Los Angeles Rams are -303 favorites to win and that means a 75% chance of landing a victory. New York Giants are trading at bigger odds than their opponents and they can be backed at +245.

The spread is currently 6.5, with the total points line at 47.5. A Total wager relates to the number of points that will be scored overall. If you’re going for Over 47.5, then the odds are -105.

You can find hundreds of team props and game lines for every National Football League matchup, with the top sportsbooks creating lots of different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Giants

+245

Rams

-303

Point Spread

Giants +6.5

-105

Rams -6.5

-115

Total Points

Under 47.5

-115

Over 47.5

-105

Kyren Williams can be backed to score a TD at any stage at -175. There is the opportunity to back the market leader to grab the first touchdown at +400.

Touchdown

Kyren Williams (Rams)

First TD

+400

Anytime TD

-175

Davante Adams (Rams)

First TD

+600

Anytime TD

-120

Puka Nacua (Rams)

First TD

+700

Anytime TD

-105

Cam Skattebo (Giants)

First TD

+700

Anytime TD

+115

Blake Corum (Rams)

First TD

+1200

Anytime TD

+200

Terrance Ferguson (Rams)

First TD

+1300

Anytime TD

+250

Malik Nabers (Giants)

First TD

+1300

Anytime TD

+200

Colby Parkinson (Rams)

First TD

+1400

Anytime TD

+250

Jaxson Dart (Giants)

First TD

+1600

Anytime TD

+280

Jordan Whittington (Rams)

First TD

+1700

Anytime TD

+340

Isaiah Likely (Giants)

First TD

+1800

Anytime TD

+290

Tyler Higbee (Rams)

First TD

+2200

Anytime TD

+490

Malachi Fields (Giants)

First TD

+2700

Anytime TD

+500

Konata Mumpfield (Rams)

First TD

+2700

Anytime TD

+550

Devin Singletary (Giants)

First TD

+3500

Anytime TD

+600

Xavier Smith (Rams)

First TD

+3500

Anytime TD

+800

Tutu Atwell (Rams)

First TD

+4000

Anytime TD

+900

Theo Johnson (Giants)

First TD

+4000

Anytime TD

+850

Darnell Mooney (Giants)

First TD

+4500

Anytime TD

+900

Najee Harris (Giants)

First TD

+5000

Anytime TD

+1000

Davis Allen (Rams)

First TD

+5500

Anytime TD

+1300

Max Klare (Rams)

First TD

+6000

Anytime TD

+1800

CJ Daniels (Rams)

First TD

+6000

Anytime TD

+1800

Tyrone Tracy Jr. (Giants)

First TD

+6500

Anytime TD

+1400

Odell Beckham Jr. (Giants)

First TD

+7500

Anytime TD

+1700

Ronnie Rivers (Rams)

First TD

+8000

Anytime TD

+2000

Matthew Stafford (Rams)

First TD

+10000

Anytime TD

+2200

Thomas Fidone (Giants)

First TD

+10000

Anytime TD

+2700

Chris Manhertz (Giants)

First TD

+10000

Anytime TD

+3300

Patrick Ricard (Giants)

First TD

+10000

Anytime TD

+4000

Braxton Berrios (Giants)

First TD

+10000

Anytime TD

+2200

Receiving Yards

Puka Nacua (Rams)

Over 84.5

-114

Under 84.5

-114

Davante Adams (Rams)

Over 62.5

-114

Under 62.5

-114

Malik Nabers (Giants)

Over 60.5

-114

Under 60.5

-114

Isaiah Likely (Giants)

Over 44.5

-114

Under 44.5

-114

Terrance Ferguson (Rams)

Over 33.5

-114

Under 33.5

-114

Colby Parkinson (Rams)

Over 30.5

-114

Under 30.5

-114

Malachi Fields (Giants)

Over 26.5

-114

Under 26.5

-114

Darnell Mooney (Giants)

Over 19.5

-114

Under 19.5

-114

Konata Mumpfield (Rams)

Over 18.5

-114

Under 18.5

-114

Xavier Smith (Rams)

Over 17.5

-114

Under 17.5

-114

Kyren Williams (Rams)

Over 16.5

-114

Under 16.5

-114

Tyler Higbee (Rams)

Over 11.5

-114

Under 11.5

-114

Cam Skattebo (Giants)

Over 11.5

-114

Under 11.5

-114

Theo Johnson (Giants)

Over 9.5

-114

Under 9.5

-114

Devin Singletary (Giants)

Over 7.5

-114

Under 7.5

-114

Odell Beckham Jr. (Giants)

Over 5.5

+114

Under 5.5

-147

Blake Corum (Rams)

Over 3.5

-102

Under 3.5

-125

Rushing Yards

Kyren Williams (Rams)

Over 63.5

-114

Under 63.5

-114

Cam Skattebo (Giants)

Over 51.5

-114

Under 51.5

-114

Blake Corum (Rams)

Over 47.5

-114

Under 47.5

-114

Jaxson Dart (Giants)

Over 33.5

-114

Under 33.5

-114

Devin Singletary (Giants)

Over 11.5

-114

Under 11.5

-114

Matthew Stafford (Rams)

Over 0.5

+172

Under 0.5

-227

Passing Yards

Matthew Stafford (Rams)

Over 238.5

-114

Under 238.5

-114

Jaxson Dart (Giants)

Over 213.5

-114

Under 213.5

-114

Instead of focusing on the overall outcome, some bettors prefer to look at the NFL micro betting lines. As the name suggests, it means placing short-term wagers and this might include the Next Play or Next Drive Result.

Rams Racking Up the Home Wins

The Rams have chalked up five straight victories at SoFi Stadium. They have a 8-2 record in their last 10 home games, putting up 26.90 points on average and giving up 18.40.

The Giants own a 1-9 mark in their past 10 games away from home, averaging 21.80 points on offense and surrendering 27.90 on defense.

The Rams earned a 17-9 win over the Giants the last time they played at SoFi Stadium.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Rams Home Stats		8-2	45.30	26.90	18.40	4	6
Giants Away Stats		1-9	49.70	21.80	27.90	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

New York Giants Stats

Los Angeles Rams Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +7.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +7.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -7.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -7.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 48.00 pts in the previous 10 games
• Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
• Over 47.5: Covered in 6 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.60 pts and allowed 24.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.80 pts and allowed 27.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 57.30 pts in the previous 10 games
• Game Totals at Home: An average of 44.60 pts in the previous 10 home games
• Over 47.5: Covered in 8 of the previous 10 games
• Over 47.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 30.00 pts and allowed 27.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.50 pts and allowed 18.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 346.10 Yds. Allowed 329.70 Yds
• Rushing Yards: Gained 141.60 Yds. Allowed 134.80 Yds
• Passing Yards: Gained 204.50 Yds. Allowed 194.90 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 21.10. Allowed 20.00
• Total Turnovers: Committed 0.90. Committed by opponents 1.10
• Total Penalties: Committed 7.40. Committed by opponents 7.10
• Penalty Yards: Lost 62.90 Yds. Gained 60.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 428.70 Yds. Allowed 367.00 Yds
• Rushing Yards: Gained 140.50 Yds. Allowed 124.60 Yds
• Passing Yards: Gained 288.20 Yds. Allowed 242.40 Yds
• Total Touchdowns: Scored 3.60 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 23.30. Allowed 20.00
• Total Turnovers: Committed 1.10. Committed by opponents 1.20
• Total Penalties: Committed 4.20. Committed by opponents 5.10
• Penalty Yards: Lost 31.30 Yds. Gained 39.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 347.30 Yds. Allowed 389.00 Yds
• Rushing Yards: Gained 113.80 Yds. Allowed 150.20 Yds
• Passing Yards: Gained 233.50 Yds. Allowed 238.80 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 19.30. Allowed 22.50
• Total Turnovers: Committed 1.10. Committed by opponents 0.40
• Total Penalties: Committed 7.80. Committed by opponents 6.90
• Penalty Yards: Lost 63.60 Yds. Gained 57.20 Yds

Last 10 Home Games

• Total Yards: Gained 373.00 Yds. Allowed 319.70 Yds
• Rushing Yards: Gained 112.60 Yds. Allowed 101.70 Yds
• Passing Yards: Gained 260.40 Yds. Allowed 218.00 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 1.70 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.30 TD
• Passing Touchdowns: Scored 2.40 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 21.70. Allowed 19.30
• Total Turnovers: Committed 0.80. Committed by opponents 1.80
• Total Penalties: Committed 5.20. Committed by opponents 5.70
• Penalty Yards: Lost 43.20 Yds. Gained 41.30 Yds

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