Seahawks vs Cardinals Prediction, Picks & Odds | 20 Sep 2026

NFL Betting Preview: Seahawks vs Cardinals

The Seattle Seahawks square off against the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:25 on Sunday, September 20.

We’re really excited to see the Seahawks at -4.5 on the spread and think it’s a great number for the favorites to cover against the Cardinals at odds of -102.

The defending Super Bowl champion Seahawks open NFC West play against an Arizona team looking to establish itself as a serious factor in the division. Seattle will turn to Drew Lock with Sam Darnold ruled out, creating an added layer of uncertainty in a road matchup where divisional familiarity should keep the intensity high.

Seattle Seahawks launched their Super Bowl title defense with a 13-10 home win against New England Patriots at Lumen Field. Seattle produced 285 total yards, including 188 net passing yards and 97 on the ground, while recording 13 first downs and scoring one touchdown.

Drew Lock stepped in after Sam Darnold suffered a hip injury on the opening drive and completed 16 of 22 passes for 187 yards and a touchdown. Jaxon Smith-Njigba caught eight passes for 122 yards, including a 45-yard fourth-quarter touchdown, while Seattle's defense intercepted Drake Maye three times in the final period.

Arizona Cardinals opened the Mike LaFleur era with a 26-14 road win against Los Angeles Chargers at SoFi Stadium. Arizona generated 393 total yards, including 277 net passing yards and 116 rushing yards, while recording 23 first downs and scoring two touchdowns.

Jacoby Brissett completed 27 of 37 passes for 277 yards and a touchdown without an interception, finishing with a 103.1 passer rating. Trey McBride caught nine passes for 95 yards and the fourth-quarter touchdown that gave Arizona a two-score lead, while rookie Jeremiyah Love scored on a five-yard run.

Head-to-Head Statistics

It was the Hawks who came out on top when they last played the Cardinals. At Lumen Field, a 44-22 win was recorded. The past 10 clashes between these teams have seen nine Hawks wins.

Quarterbacks

Drew Lock

207.5 Passing Yards

Over -114

Under -114

Jacoby Brissett

216.5 Passing Yards

Over -114

Under -114

Seahawks vs Cardinals Prediction & Picks

Gear up for Seahawks vs Cardinals with our comprehensive betting guide, featuring an expert match prediction, scoreline advice, top player props and a hand-picked bet builder.

Game Prediction

The Seahawks can cover the -4.5 betting line in this NFL matchup. We’re confident of a strong showing and a spread bet could be the best play at odds of -102.

We use the latest team news and injury updates to help shape the best possible NFL picks. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Seahawks vs Cardinals stats:

• The -4.5 line has been covered by Seahawks in 5 consecutive games on the road.
• The -4.5 line has been covered by Seahawks in 8 of their last 10 games on the road.
• The -4.5 line has been covered by Seahawks in 13 of their last 20 games.
• The +4.5 line hasn’t been covered by Cardinals in 4 of their last 5 games.
• The +4.5 line hasn’t been covered by Cardinals in 7 of their last 10 games.
• The +4.5 line hasn’t been covered by Cardinals in 2 consecutive games at home.
• The +4.5 line hasn’t been covered by Cardinals in 7 of their last 10 games against Seahawks.

Hawks -4.5 Probability

If you go by the best betting sites, our pick has a 50.5% chance of winning. However, our analysts research has found that the actual probability is closer to 60%. This is why we can recommend this bet.

Looking for more juice from your point spread wager? By moving the line, you are able to get bigger odds although you will need to take a riskier bet.

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Our Game Prediction

Seahawks -4.5 @ -102 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 18, 22:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Drew Lock Over 207.5 Passing Yards -114

Drew Lock (Hawks) is available at -114 to rack up over 207.5 passing yards. We’re happy to take him to cover the QB Passing Yards line and bettors can place this wager with confidence.

Latest Drew Lock Player Prop Odds

Touchdown

Anytime

+480

First

+1900

Passing Yards

Over 207.5

-114

Under 207.5

-114

Rushing Yards

Over 7.5

-114

Under 7.5

-114

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Trey McBride Over 60.5 Receiving Yards -114

You can back Trey McBride (Hawks) at -114 to record more than 60.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.

Latest Trey McBride Player Prop Odds

Touchdown

Anytime

+200

First

+1000

Receiving Yards

Over 60.5

-114

Under 60.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Seahawks 28 - 17 Cardinals

There's a speculative wager that can be enjoyed on the Hawks when it comes to the correct score lines. Taking them to triumph 28-17 should provide some entertainment.

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Seahawks vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Seattle Seahawks have the shortest price to win this game, with the sportsbooks giving them a 68% probability due to their -208 Moneyline betting odds. For those wanting to back Arizona Cardinals, you will find +176 about the underdogs.

4.5 is the spread and 41.5 is the total points line. The advantage of the Totals is that you only have to choose from one of two options. The Over 41.5 selection is available to back at -102.

Take a well-rounded approach when placing your bets. The top NFL betting sites are packed with team props and game lines, so focus on finding the selection that reflects your read on the matchup.

Moneyline

Seahawks

-208

Cardinals

+176

Point Spread

Seahawks -4.5

-102

Cardinals +4.5

-120

Total Points

Under 41.5

-120

Over 41.5

-102

The Anytime Touchdown betting indicates that Jadarian Price has odds of %anytime_odds%. He is available at %first_odds% to score the first TD which makes him favorite.

Touchdown

Jadarian Price (Seahawks)

First TD

+700

Anytime TD

+155

Jaxon Smith-Njigba (Seahawks)

First TD

+700

Anytime TD

+140

Jeremiyah Love (Cardinals)

First TD

+950

Anytime TD

+195

George Holani (Seahawks)

First TD

+1000

Anytime TD

+220

Trey McBride (Cardinals)

First TD

+1000

Anytime TD

+200

Tyler Allgeier (Cardinals)

First TD

+1000

Anytime TD

+210

AJ Barner (Seahawks)

First TD

+1300

Anytime TD

+320

Rashid Shaheed (Seahawks)

First TD

+1500

Anytime TD

+390

Marvin Harrison Jr. (Cardinals)

First TD

+1800

Anytime TD

+380

Cooper Kupp (Seahawks)

First TD

+1800

Anytime TD

+390

Michael Wilson (Cardinals)

First TD

+1800

Anytime TD

+390

Drew Lock (Seahawks)

First TD

+1900

Anytime TD

+480

Emanuel Wilson (Seahawks)

First TD

+2700

Anytime TD

+700

Kendrick Bourne (Cardinals)

First TD

+3000

Anytime TD

+700

Jacoby Brissett (Cardinals)

First TD

+3000

Anytime TD

+800

Tory Horton (Seahawks)

First TD

+3500

Anytime TD

+1000

Elijah Arroyo (Seahawks)

First TD

+5000

Anytime TD

+1300

Elijah Higgins (Cardinals)

First TD

+5000

Anytime TD

+1300

Hunter Long (Cardinals)

First TD

+6000

Anytime TD

+1500

Eric Saubert (Seahawks)

First TD

+7500

Anytime TD

+2200

Nick Kallerup (Seahawks)

First TD

+8000

Anytime TD

+2700

Devin Duvernay (Cardinals)

First TD

+10000

Anytime TD

+2700

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+3000

Reggie Virgil (Cardinals)

First TD

+10000

Anytime TD

+3000

Bam Knight (Cardinals)

First TD

+10000

Anytime TD

+3500

Brady Russell (Seahawks)

First TD

+10000

Anytime TD

+4000

Jalen Brooks (Cardinals)

First TD

+10000

Anytime TD

+4000

Montorie Foster Jr. (Seahawks)

First TD

+10000

Anytime TD

+5000

Receiving Yards

Jaxon Smith-Njigba (Seahawks)

Over 81.5

-114

Under 81.5

-114

Trey McBride (Cardinals)

Over 60.5

-114

Under 60.5

-114

Michael Wilson (Cardinals)

Over 37.5

-114

Under 37.5

-114

Marvin Harrison Jr. (Cardinals)

Over 37.5

-114

Under 37.5

-114

Kendrick Bourne (Cardinals)

Over 24.5

-114

Under 24.5

-114

Rashid Shaheed (Seahawks)

Over 24.5

-114

Under 24.5

-114

Cooper Kupp (Seahawks)

Over 23.5

-114

Under 23.5

-114

AJ Barner (Seahawks)

Over 22.5

-114

Under 22.5

-114

Jeremiyah Love (Cardinals)

Over 17.5

-114

Under 17.5

-114

Jadarian Price (Seahawks)

Over 7.5

-114

Under 7.5

-114

Rushing Yards

Jadarian Price (Seahawks)

Over 60.5

-114

Under 60.5

-114

Jeremiyah Love (Cardinals)

Over 36.5

-114

Under 36.5

-114

Tyler Allgeier (Cardinals)

Over 34.5

-114

Under 34.5

-114

George Holani (Seahawks)

Over 29.5

-114

Under 29.5

-114

Jacoby Brissett (Cardinals)

Over 9.5

-114

Under 9.5

-114

Drew Lock (Seahawks)

Over 7.5

-114

Under 7.5

-114

Passing Yards

Jacoby Brissett (Cardinals)

Over 216.5

-114

Under 216.5

-114

Drew Lock (Seahawks)

Over 207.5

-114

Under 207.5

-114

Micro betting provides a rollercoaster ride for NFL bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Cardinals With Seven Consecutive Home Losses

The Cardinals are on a run of seven straight losses at State Farm Stadium. They have a 3-7 record in their last 10 home games, posting 25.00 points per contest while yielding 27.40.

The Seahawks have reeled off five straight road wins. Seattle is 9-1 in their last 10 games on the road, posting 26.70 points per contest while yielding 14.30.

The last time the teams met at State Farm Stadium, the Hawks defeated the Cardinals 23-20. Looking at the last 7 head-to-heads at State Farm Stadium, the Hawks have tallied six victories, with the Cardinals winning once.

Last 10 Games		W-L	P	PF	PA	O41.5	U41.5
Cardinals Home Stats		3-7	52.40	25.00	27.40	10	0
Seahawks Away Stats		9-1	41.00	26.70	14.30	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O41.5 = Games Over 41.5 Points
• U41.5 = Games Under 41.5 Points

Latest regular season and playoff games stats.

Seattle Seahawks Stats

Arizona Cardinals Stats

Moneyline

• 10 wins and 0 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 40.40 pts in the previous 10 games
• Game Totals on the Road: An average of 41.00 pts in the previous 10 games on the road
• Over 41.5: Covered in 5 of the previous 10 games
• Over 41.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.30 pts and allowed 13.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.70 pts and allowed 14.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.20 pts in the previous 10 games
• Game Totals at Home: An average of 52.40 pts in the previous 10 home games
• Over 41.5: Covered in 8 of the previous 10 games
• Over 41.5 at Home: Covered in the previous 10 home games
• Team Totals: Have scored an average of 20.10 pts and allowed 33.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.00 pts and allowed 27.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 325.90 Yds. Allowed 286.70 Yds
• Rushing Yards: Gained 130.60 Yds. Allowed 96.90 Yds
• Passing Yards: Gained 195.30 Yds. Allowed 189.80 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 1.20 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.20 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 0.40 TD
• Total 1st Downs: Picked up 19.20. Allowed 16.30
• Total Turnovers: Committed 0.80. Committed by opponents 2.20
• Total Penalties: Committed 5.10. Committed by opponents 5.20
• Penalty Yards: Lost 40.20 Yds. Gained 39.60 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 341.90 Yds. Allowed 366.60 Yds
• Rushing Yards: Gained 80.70 Yds. Allowed 141.00 Yds
• Passing Yards: Gained 261.20 Yds. Allowed 225.60 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.90 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 19.90. Allowed 22.50
• Total Turnovers: Committed 1.30. Committed by opponents 1.10
• Total Penalties: Committed 6.70. Committed by opponents 4.60
• Penalty Yards: Lost 55.00 Yds. Gained 34.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 365.90 Yds. Allowed 254.50 Yds
• Rushing Yards: Gained 128.20 Yds. Allowed 91.10 Yds
• Passing Yards: Gained 237.70 Yds. Allowed 163.40 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 1.60 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 20.10. Allowed 14.90
• Total Turnovers: Committed 1.10. Committed by opponents 1.60
• Total Penalties: Committed 5.60. Committed by opponents 6.00
• Penalty Yards: Lost 45.00 Yds. Gained 46.20 Yds

Last 10 Home Games

• Total Yards: Gained 347.20 Yds. Allowed 359.60 Yds
• Rushing Yards: Gained 102.10 Yds. Allowed 126.00 Yds
• Passing Yards: Gained 245.10 Yds. Allowed 233.60 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 20.20. Allowed 22.40
• Total Turnovers: Committed 1.20. Committed by opponents 1.50
• Total Penalties: Committed 7.40. Committed by opponents 6.30
• Penalty Yards: Lost 52.30 Yds. Gained 54.10 Yds

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