South Florida vs DePaul Prediction, Picks & Odds | 05 Nov 2026

South Florida vs DePaul Predictions

Best Bet

South Florida +6.5 @ -110

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If you agree that South Florida can push DePaul to the wire, then bet the underdogs against the spread here. The +6.5 makes plenty of appeal at odds of -110.

We've selected our Best Bet for South Florida vs DePaul, along with a Same Game Parlay and Correct Score Prediction. Each dedicated breakdown offers insight into the reasoning for the picks.

South Florida vs DePaul Preview

The South Florida Bulls square off against the DePaul Blue Demons, with tip-off scheduled for 20:30 on Thursday, November 5.

South Florida Bulls won their previous game, beating Charleston Southern Buccaneers at home. It was a 98-71 win.

DePaul Blue Demons won their last game which was at home. It was a 75-58 triumph against West Georgia Wolves.

H2H: USF Won 77-65 When Teams Last Met

The last head-to-head saw USF claim a 77-65 win over DePaul. USF have won two of the past 3 games that these teams have played.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
DePaul	1-0	75	58	17	1-0	0-0	1W
South Florida	1-0	98	71	27	1-0	0-0	1W

View Full Standings

Best Bet

The betting line makes lots of appeal considering it’s set at +6.5 and our prediction is that South Florida should be able to cover it in this college showdown. There is -110 available for this outcome.

Key stats supporting our main match prediction:

• The +6.5 line has been covered by USF in 20 consecutive games.
• The -6.5 line hasn’t been covered by DePaul in 8 of their last 10 games at home.
• The -6.5 line hasn’t been covered by DePaul in 4 of their last 5 games at home.
• The -6.5 line hasn’t been covered by DePaul in 3 consecutive games against USF.

Tracking injury updates is a big part of our college hoops analysis and team news plays a major role in shaping our basketball picks. We combine this with recent form and the most important stats to get a complete picture.

USF +6.5 Probability

The best betting sites suggest there’s a 52.4% chance of our pick delivering a return. Our experts think there’s a stronger chance of success and calculate the probability to be 55-60%. It’s the reason why we are recommending this college basketball bet.

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South Florida +6.5 @ -110 Bet Now

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Correct Score Prediction

South Florida 70 - 74 DePaul

There are massive odds on offer when it comes to the Blue Demons landing a 74-70 win. A close game is anticipated between two evenly-matched teams.

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South Florida vs DePaul Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With the sportsbooks giving them a 74% probability of winning this college game, DePaul might be a popular parlay pick. That is reflected in their -278 Moneyline betting odds. South Florida are trading at bigger odds than their opponents and they can be backed at +225.

The spread is 6.5 and the total points line is currently 150.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 150.5 at -105.

College basketball bettors are spoilt for choice thanks to the huge selection of game lines and team props which are available for most matchups on the coupon. Head to the top betting apps and find the best value picks.

Moneyline

USF

+225

DePaul

-278

Point Spread

USF +6.5

-110

DePaul -6.5

-110

Total Points

Under 150.5

-105

Over 150.5

-115

Latest regular season and playoff games stats.

South Florida Stats

DePaul Stats

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 2 of the last 10 home games

Total Points

• Game Totals: An average of 153.40 pts in the previous 10 games
• Game Totals on the Road: An average of 156.90 pts in the previous 10 games on the road
• Over 150.5: Covered in 6 of the previous 10 games
• Over 150.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 84.70 pts and allowed 68.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 82.30 pts and allowed 74.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 136.30 pts in the previous 10 games
• Game Totals at Home: An average of 133.10 pts in the previous 10 home games
• Over 150.5: Covered in 2 of the previous 10 games
• Over 150.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 67.40 pts and allowed 68.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 65.80 pts and allowed 67.30 pts in the last 10 home games

NCAAB Table Select Season 2026/20272025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
Butler	2-0	195	125	70	2-0	0-0	2W
Xavier	1-0	97	52	45	1-0	0-0	1W
UConn	1-0	86	46	40	1-0	0-0	1W
Marquette	1-0	78	43	35	1-0	0-0	1W
Providence	1-0	83	56	27	1-0	0-0	1W
Seton Hall	1-0	66	42	24	1-0	0-0	1W
Georgetown	1-0	80	58	22	1-0	0-0	1W
DePaul	1-0	75	58	17	1-0	0-0	1W
Creighton	1-0	76	61	15	1-0	0-0	1W
St. John's	1-0	78	63	15	1-0	0-0	1W
Villanova	0-1	72	74	-2	0-1	0-0	1L

American Athletic Conference	Overall	PF	PA	N. Pts	Home	Away	Strk
North Texas	1-0	122	50	72	1-0	0-0	1W
Tulsa	1-0	98	50	48	1-0	0-0	1W
Rice	1-0	100	55	45	1-0	0-0	1W
South Florida	1-0	98	71	27	1-0	0-0	1W
East Carolina	1-0	83	70	13	1-0	0-0	1W
Temple	1-0	68	56	12	1-0	0-0	1W
Wichita State	1-0	79	67	12	1-0	0-0	1W
Charlotte	1-0	78	70	8	0-0	1-0	1W
Memphis	1-0	80	76	4	0-0	1-0	1W
Tulane	1-0	100	98	2	1-0	0-0	1W
UTSA	0-1	74	95	-21	0-0	0-1	1L
UAB	0-1	78	99	-21	0-0	0-1	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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