Syracuse vs Louisville Prediction, Picks & Odds | 03 Mar 2026

College Basketball Betting Preview: Syracuse vs Louisville

The Syracuse Orange battle the Louisville Cardinals, with tip-off scheduled for 21:00 on Tuesday, March 3.

We’re predicting a one-sided affair when Louisville meet Syracuse. We should therefore take this selection at -120 to cover the -12.5 line on the spread.

Syracuse Orange suffered a defeat in their previous game. A 88-83 scoreline occurred on the road against Wake Forest Demon Deacons.

Louisville Cardinals lost on the road in their last game. Clemson Tigers won 80-75.

Head-to-Head Statistics

The scoreline was 85-61 in favor of Louisville when they last played Syracuse. In the past 8 games between the teams, Syracuse have won six.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Louisville	2-0	191	127	64	2-0	0-0	2W
Syracuse	2-0	176	107	69	2-0	0-0	2W

View Full Standings

Syracuse vs Louisville Prediction & Picks

Our Syracuse vs Louisville betting guide delivers expert insight, including a main match pick, our correct score angle and bet builder recommendations. Dive into each section below for more.

Game Prediction

Let’s go for the big favorites at a generous -12.5 on the spread. We like this pick and are able to get -120 that Louisville win this college showdown by a sizeable margin.

To deliver the best possible basketball picks, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date college hoops stats available.

Key Syracuse vs Louisville stats:

• The -12.5 line has been covered by Louisville in 4 of their last 5 games at home.
• The -12.5 line has been covered by Louisville in 7 of their last 10 games at home.
• The -12.5 line has been covered by Louisville in 2 consecutive games at home.
• The +12.5 line hasn’t been covered by Syracuse in 3 of their last 5 games on the road.

Louisville -12.5 Probability

The top sportsbooks imply that our pick has a 54.6% prospect of winning. Based on our analysts research, we calculate the actual probability to be closer to 60%. It’s why we think it’s worth placing this college basketball bet.

If you want to pimp the odds about Louisville covering the line, you might consider going down the Bet Builder route and combine this prediction with other selections.

Don’t miss your chance to claim the best betting offers, free bets, and bonuses with the help of our smart bonus guide.

Our Game Prediction

Louisville -12.5 @ -120 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 3, 01:03). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Syracuse 74 - 90 Louisville

There are lots of different ways to back Louisville on the correct score betting and something like 90-74 in their favor might be along the right lines at massive odds.

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Syracuse vs Louisville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The latest Moneyline betting odds give Louisville a 93% chance of winning this college game which means they’re overwhelming -1429 favorites with the sportsbooks. Syracuse are regarded as a long shot to win and you can currently back them at +810.

The spread currently stands at 13.5 and the total points line is 159.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. If you’re going for Over 159.5, then the odds are -110.

The top basketball sportsbooks offer a huge selection of game lines and team props when it comes to most college games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Syracuse

+810

Louisville

-1429

Point Spread

Syracuse +13.5

-102

Louisville -13.5

-120

Total Points

Under 159.5

-110

Over 159.5

-110

If you’re looking for an alternative to the main game lines, check out the player props instead. It’s great to wager on Total Points, Three-Pointers, Assists, Steals, Blocks and Rebounds as potential options.

For those looking to enjoy a thrilling in-game wager, college basketball micro betting could be up your street. You are now able to wager on the Next Field Goal, with the options being for a two-pointer or a three-pointer.

Latest regular season and playoff games stats.

Syracuse Stats

Louisville Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +12.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +12.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -12.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -12.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 161.10 pts in the previous 10 games
• Game Totals on the Road: An average of 154.00 pts in the previous 10 games on the road
• Over 157.5: Covered in 6 of the previous 10 games
• Over 157.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 76.30 pts and allowed 84.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 71.30 pts and allowed 82.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 159.70 pts in the previous 10 games
• Game Totals at Home: An average of 157.40 pts in the previous 10 home games
• Over 157.5: Covered in 4 of the previous 10 games
• Over 157.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 82.50 pts and allowed 77.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 86.50 pts and allowed 70.90 pts in the last 10 home games

NCAAB Table Select Season 2026/20272025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Virginia	3-0	277	204	73	3-0	0-0	3W
Pittsburgh	3-0	257	194	63	3-0	0-0	3W
Duke	2-0	197	102	95	2-0	0-0	2W
Syracuse	2-0	176	107	69	2-0	0-0	2W
Florida State	2-0	203	137	66	2-0	0-0	2W
Louisville	2-0	191	127	64	2-0	0-0	2W
Virginia Tech	2-0	184	121	63	2-0	0-0	2W
North Carolina	2-0	189	142	47	2-0	0-0	2W
Boston College	2-0	147	105	42	2-0	0-0	2W
SMU	2-0	180	142	38	2-0	0-0	2W
NC State	2-0	160	127	33	2-0	0-0	2W
Georgia Tech	2-0	170	138	32	2-0	0-0	2W
Notre Dame	2-0	157	128	29	1-0	1-0	2W
Clemson	2-0	167	145	22	2-0	0-0	2W
California	2-1	267	242	25	2-1	0-0	1L
Miami	1-1	150	134	16	1-0	0-1	1W
Wake Forest	1-1	134	136	-2	1-0	0-1	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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