Villanova vs DePaul Prediction, Picks & Odds | 04 Mar 2026

College Basketball Betting Preview: Villanova vs DePaul

The Villanova Wildcats square off against the DePaul Blue Demons, with tip-off scheduled for 20:00 on Wednesday, March 4.

Let’s go for Over 135.5 when Villanova face DePaul. We think the line is too generous and we’re expecting the final total to be higher at odds of -105.

Villanova Wildcats were beaten in their previous game and this was on the road. St. John's Red Storm claimed a 89-57 win.

DePaul Blue Demons got the win in their last game. A 62-51 triumph occurred on the road when meeting Marquette Golden Eagles.

Head-to-Head Statistics

Villanova beat DePaul when the teams last met. It was a 71-66 scoreline. Villanova have beaten DePaul in the past seven meetings. They’ve also claimed 9 victories in the past 10 head-to-head matchups.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Villanova	24-8	2469	2265	204	15-4	9-4	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L

View Full Standings

Villanova vs DePaul Prediction & Picks

This expert Villanova vs DePaul betting breakdown features our match prediction, a correct score tip, player prop suggestions and a carefully constructed bet builder to guide your wagers.

Game Prediction

There’s juice available when it comes to backing Over 135.5 points in this college game and that’s the betting angle we’re pursuing. Our pick is priced up at -105 which looks worth taking.

Our expert college basketball handicappers study recent form and take injuries into account when assessing each matchup. Before delivering a verdict, we combine that insight with the latest stats to strengthen our analysis.

Key Villanova vs DePaul stats:

• The 135.5 line has been covered in the last 8 Villanova games on the road.
• The 135.5 line has been covered in 9 of the last 10 Villanova games.
• The 135.5 line has been covered in 17 of the last 20 Villanova games.
• The 135.5 line has been covered in 15 of the last 20 DePaul games at home.
• The 135.5 line has been covered in 6 of the last 10 DePaul games at home.
• The 135.5 line has been covered in the last 2 DePaul games at home.

Over 135.5 Probability

According to the best sportsbooks, there’s a 51.3% likelihood of our pick landing a return. Based on our in-depth research, we calculate the actual probability to be 55-60%. This is why we regard this as a value bet.

Want more juice from your Over bet on the Totals? Bigger odds can be found if you move the line and go for a riskier wager. You can choose from a range of options.

Thinking about placing a wager? Explore our updated guide filled with top betting offers, free bets, and promotions.

Our Game Prediction

Over 135.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 4, 00:02). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: RJ Smith Over 2.5 Assists +125

RJ Smith (DePaul) can be backed to rack up Over 2.5 assists at +125. He looks capable of covering the line and that leads us to taking this Player Assists bet.

Latest RJ Smith Player Prop Odds

Points

Over 5.5

-141

Under 5.5

+110

Assists

Over 2.5

+125

Under 2.5

-161

Rebounds

Over 2.5

-118

Under 2.5

-110

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Duke Brennan Under 1.5 Assists -100

Duke Brennan (Villanova) can be backed to register Under 1.5 assists at -100. Taking everything into consideration, we can feel confident that he will fall short of the line.

Latest Duke Brennan Player Prop Odds

Points

Over 10.5

-130

Under 10.5

-100

Assists

Over 1.5

-135

Under 1.5

+105

Rebounds

Over 9.5

-141

Under 9.5

+105

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Villanova 69 - 70 DePaul

We’re expecting this to be a close game and we’ll take the Blue Demons to win 70-69. This is available at huge odds for those that want to have a speculative wager.

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Villanova vs DePaul Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Villanova odds have been priced up by the sportsbooks and they are -141 betting favorites to land victory in this college game which means a 58% chance of winning. For those wanting to oppose the market leader, you can get +116 about DePaul.

2.5 is the spread and 135.5 is the total points line. A Total wager relates to the number of points that will be scored overall. If you’re going for Over 135.5, then the odds are -108.

If you’re planning to place a bet on a college hoops matchup, visit the top basketball betting sites and check out the many available game lines and team props. Find the lines which are the most attractive.

Moneyline

Villanova

-141

DePaul

+116

Point Spread

Villanova -2.5

-104

DePaul +2.5

-118

Total Points

Under 135.5

-112

Over 135.5

-108

Tyler Perkins is the favorite to land the most baskets. You can get -120 that he scores Over 15.5 points or -105 that he goes Under.

Tyler Perkins (Villanova)

Over 15.5

-120

Under 15.5

-105

Brandon Maclin (DePaul)

Over 14.5

-105

Under 14.5

-120

Acaden Lewis (Villanova)

Over 13.5

-110

Under 13.5

-120

NJ Benson (DePaul)

Over 11.5

-135

Under 11.5

-100

Duke Brennan (Villanova)

Over 10.5

-130

Under 10.5

-100

Layden Blocker (DePaul)

Over 10.5

-110

Under 10.5

-115

RJ Smith (DePaul)

Over 5.5

-141

Under 5.5

+110

Acaden Lewis (Villanova)

Over 4.5

-120

Under 4.5

-110

Layden Blocker (DePaul)

Over 2.5

-175

Under 2.5

+130

RJ Smith (DePaul)

Over 2.5

+125

Under 2.5

-161

NJ Benson (DePaul)

Over 1.5

+135

Under 1.5

-175

Duke Brennan (Villanova)

Over 1.5

-135

Under 1.5

+105

Duke Brennan (Villanova)

Over 9.5

-141

Under 9.5

+105

NJ Benson (DePaul)

Over 9.5

+115

Under 9.5

-149

Acaden Lewis (Villanova)

Over 3.5

-105

Under 3.5

-120

Layden Blocker (DePaul)

Over 2.5

-110

Under 2.5

-118

RJ Smith (DePaul)

Over 2.5

-118

Under 2.5

-110

There are some exciting college basketball micro betting lines that are created and they are available in-game. Among them are Next Field Goal, where you select if the shot will be a two or three-pointer. The long-ball option pays better, and in today’s game, you can never discount the three-pointer.

Latest regular season and playoff games stats.

Villanova Stats

DePaul Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 150.50 pts in the previous 10 games
• Game Totals on the Road: An average of 151.20 pts in the previous 10 games on the road
• Over 135.5: Covered in 9 of the previous 10 games
• Over 135.5 on the Road: Covered in 9 of the previous 10 games on the road
• Team Totals: Have scored an average of 75.70 pts and allowed 74.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 75.00 pts and allowed 76.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 134.20 pts in the previous 10 games
• Game Totals at Home: An average of 137.20 pts in the previous 10 home games
• Over 135.5: Covered in 4 of the previous 10 games
• Over 135.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 66.50 pts and allowed 67.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 70.70 pts and allowed 66.50 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
St. John's	28-6	2773	2379	394	18-3	10-3	6W
Villanova	24-8	2469	2265	204	15-4	9-4	1L
Seton Hall	21-12	2321	2156	165	13-5	8-7	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Georgetown	16-18	2503	2479	24	10-8	6-10	1L
Creighton	15-17	2404	2401	3	11-6	4-11	1L
Providence	15-18	2815	2772	43	10-7	5-11	1L
Xavier	15-18	2586	2661	-75	13-7	2-11	1L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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