San Luis vs Santos Laguna Prediction, Betting Tips, Lineups & Odds | 22 Apr 2026

Liga MX Betting Preview: San Luis vs Santos Laguna

San Luis host Santos Laguna at Estadio Alfonso Lastras, with kick-off set for 21:00 on Wednesday 22 April.

It’s great to get attractive odds of -128 for a home win when San Luis go up against Santos Laguna. We think that the hosts will have the upper hand and the Full-Time Result market is a way of getting the best value.

Atlético San Luis lost their last game, suffering a 2-0 home defeat to Pumas UNAM at Estadio Alfonso Lastras. Los Atléticos had 52% possession and recorded three shots on target.

Santos Laguna suffered a second consecutive Liga MX defeat when losing 1-0 in their previous league game. This was at home to Atlas at Estadio Nuevo Corona. Omar Tapia's team boasted 54% possession and recorded two shots on goal.

Head-to-Head Statistics

It’s been four victories on the bounce for San Luis when playing Santos. In their last encounter, visitors San Luis secured a 4-1 win at Estadio Nuevo Corona. The past 10 H2H games have involved four wins each and two draws.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
14	San Luis	17	5	3	9	24	27	-3	24:27	18
18	Santos Laguna	17	3	3	11	20	38	-18	20:38	12

View Full Table

3 wins, 5 losses and 2 draws, averaging 1.4 goals from 8.8 attempts and 4.0 shots on goal. San Luis have had 49.3% possession and 4.0 corners per match. On average, the opposition have scored 1.5 goals from 13.6 attempts and 6.4 shots on goal, while earning 3.6 corners.

Joao Pedro leads the way with 7 goals, Sebastien Lamonge has 2, with David Rodriguez and two others on 1. Sebastien Lamonge, Jesus Medina and Santiago Munoz are the leading assists makers with 2.

Santos have 2 victories, 6 defeats and 2 draws, averaging 9.2 attempts, 4.2 shots on goal and 1.2 goals. Los Guerreros average 48.1% possession, 4.5 corners awarded and 4.3 corners against them, while 1.9 goals have been conceded from 5.2 shots on goal and 12.2 attempts.

Ezequiel Bullaude got 4 goals, Lucas Di Yorio notched 3, while Cristian Dajome and two other players scored 1. Lucas Di Yorio has managed to clock up 3 assists in the last 10 games.

Confirmed Lineups

San Luis confirmed lineup (4-4-2): Andres Sanchez (GK), Roman Torres, Robson Bambu, Eduardo Aguila, Aldo Cruz, David Rodriguez, Roberto Meraz, Oscar Macias, Lucas Esteves, Joao Pedro, Sebastien Lamonge.

Santos Laguna confirmed lineup (4-3-1-2): Hector Holguin (GK), Kevin Picon, Kevin Balanta, Bruno Amione, Emmanuel Echeverria, Salvador Mariscal, Aldo Lopez, Javier Guemez, Fran Villalba, Ezequiel Bullaude, Lucas Di Yorio.

San Luis vs Santos Laguna Prediction & Betting Tips

Our expert San Luis vs Santos Laguna tips include betting advice on all fronts — from a main match prediction and player prop picks to corners guidance, a correct score selection and a ready-made bet builder.

Match Prediction

San Luis have the capability of securing a victory when they line up in this Liga MX game. For this reason, we are going to take betting odds of -128 with a large degree of confidence.

The first step involves analysing the form and also getting an idea of the injury situation before making any football picks. Then it’s a case of consulting the latest Liga MX stats and seeing if they can inform our opinion.

Key San Luis vs Santos Laguna league stats:

• Santos have lost 14 of their last 18 games on the road.
• Santos have lost 7 of their last 10 games on the road.
• Santos have lost their last 2 games.
• San Luis have won the last 4 games between these teams.

The latest odds imply that our pick has a 56.2% prospect of winning. After careful examination, our experts calculate this probability to be somewhere between 60-65%. It’s why we think it’s worth placing this wager.

For those bettors who want to boost their odds for San Luis to secure a victory, why not combine this pick with some of the other available options in a Bet Builder.

Before placing your bets, take advantage of our guide packed with up-to-date free bets and the latest bonus offers.

Our Match Prediction

San Luis To Win @ -128 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Apr 21, 03:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

San Luis 2 - 1 Santos

A 2-1 win in favor of San Luis is available at odds of +575. Take a chance on the correct score and get rewarded for predicting the right scoreline.

Player Prop Picks

Top Pick: Ezequiel Bullaude to Score +320

Ezequiel Bullaude (Santos) has managed four goals in his past ten Liga MX matches. This statistic guides us towards Anytime Goalscorer where we’re able to back him to find the net at appealing odds of +320.

Latest Ezequiel Bullaude Player Prop Odds

Goalscorer

Anytime

+320

First

+1000

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Corners Prediction

Under 10.5 Corners -143

We’ve seen under 10.5 corners in eight consecutive San Luis home games. For Total Corners, we’re expecting the sides to fall short and you can get odds of -143.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

San Luis

Total

7.60 4.00 3.60

Home

8.00 5.00 3.00

Away

7.00 3.60 3.40

Santos

Total

8.80 4.50 4.30

Home

9.80 4.90 4.90

Away

9.20 4.10 5.10

Latest Corner Odds

Total Corners

Over 9.5

-139

Under 9.5

-106

San Luis Corners

Over 5.5

-135

Under 5.5

-115

Santos Corners

Over 3.5

-143

Under 3.5

-109

Most Corners

1

-217

X

+700

2

+210

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

San Luis vs Santos Laguna Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a roughly 57% chance of triumphing, the bookmakers aren’t giving too much away with their -135 betting odds for Atlético San Luis winning this Liga MX clash. At +310, Santos Laguna are regarded as having a lower probability of winning.

San Luis are -105 if you take them on the Asian Handicap at -0.75. Stakes are split between -0.5 and -1 which means you need a 2+ goal win for a full payout. A one-goal victory means a return with half your stake and the other half refunded.

The Total Goals market indicates that Over 2.5 Goals is the betting favourite right now. The Yes pick in the Both Teams to Score market is considered to be the most likely result and it’s trading at -204.

The top football betting sites ensure that customers are able to choose from a wide range of options. It’s no exaggeration that they provide hundreds of markets when it comes to Liga MX games.

Full-Time Result

1

-135

X

+290

2

+310

Half-Time Result

1

+120

X

+140

2

+310

Double Chance

1X

-500

12

-455

X2

-103

Draw No Bet

1

-313

2

+195

Asian Handicap

1 Hcp -0.75

-105

2 Hcp +0.75

-122

Total Goals

Under 2.5

+140

Over 2.5

-192

Both Teams to Score

Yes

-204

No

+135

There’s the chance to back João Galvão at +310 to be the First Goalscorer, with the favourite on this market available at similar odds to find the net last.

João Galvão (San Luis)

First

-105

Anytime

+310

Fidel Barajas (San Luis)

First

+200

Anytime

+575

Santiago Muñoz (San Luis)

First

+220

Anytime

+650

Lucas Di Yorio (Santos)

First

+230

Anytime

+700

Jesús Medina (San Luis)

First

+250

Anytime

+750

David Rodríguez (San Luis)

First

+270

Anytime

+800

Ramiro Sordo (Santos)

First

+280

Anytime

+800

Benjamín Galdames (San Luis)

First

+320

Anytime

+900

Ezequiel Bullaude (Santos)

First

+320

Anytime

+1000

Fran Villalba (Santos)

First

+380

Anytime

+1100

Cristian Dájome (Santos)

First

+475

Anytime

+1400

Salvador Mariscal Murra (Santos)

First

+550

Anytime

+1500

Roberto Meraz (San Luis)

First

+550

Anytime

+1600

Julio Domínguez (San Luis)

First

+575

Anytime

+1600

Javier Güemez (Santos)

First

+650

Anytime

+2000

Lucas Esteves (San Luis)

First

+750

Anytime

+2200

Eduardo Aguila (San Luis)

First

+750

Anytime

+2200

Emmanuel Echeverria (Santos)

First

+800

Anytime

+2200

Aldo Cruz (San Luis)

First

+800

Anytime

+2200

Stats: Liga MX matches only
San Luis haven’t tasted victory at Estadio Alfonso Lastras in the previous three matches. Los Atléticos have finished with seven losses, two victories and one draw in the past 10 home games, scoring an average of 1.60 goals per match and conceding 1.80.

Santos have seven losses, two draws and one victory in the last 10 away matches, recording an average of 1.20 goals per game and conceding 3.00.

San Luis overcame Santos 3-1 when the sides last met at Estadio Alfonso Lastras. The 6 H2H games most recently played at Estadio Alfonso Lastras have included three Santos victories, one draw and two triumphs for San Luis.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
San Luis Home Stats		2-1-7	3.40	1.60	1.80	7	3	7	3
Santos Laguna Away Stats		1-2-7	4.20	1.20	3.00	10	0	8	2

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

San Luis vs Santos Laguna Lineups & Team News

Before making your bets, take a look at the San Luis vs Santos team news. Stay in the know with our predicted and confirmed Liga MX lineups and the latest on injuries.

San Luis Team Page Santos Laguna Team Page

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