Santos Laguna vs Pumas Prediction, Betting Tips, Lineups & Odds | 21 Oct 2026

Santos Laguna vs Pumas Predictions

Main Match Prediction

Santos Asian Hcp 0.0 @ -141

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We’re happy to side with Santos Laguna 0.0 on the Asian Handicap when they take on Pumas. At odds of -141, we get a return if the hosts win and there’s the insurance of money back if the game is drawn.

Continue below for our full Santos Laguna vs Pumas betting breakdown, where you can read the complete analysis of our main match prediction, as well as our correct score prediction, player prop picks, corners prediction and bet builder tips.

Santos Laguna vs Pumas Preview

Santos Laguna welcome Pumas to Estadio Nuevo Corona, with kick-off set for 23:10 on Wednesday 21 October.

Santos Laguna secured their fifth consecutive league win in their latest Liga MX game, defeating Querétaro 5-0 at home at Estadio Nuevo Corona. Los Guerreros had five shots on target and boasted 59% possession, while Tahiel Jimenez fired home a hat-trick.

Pumas UNAM won their previous game 2-1. This was an away victory at Estadio Quintana Roo against Atlante F.C.. Esteban Solari's side recorded two shots on goal and had 52% possession, while Juninho scored twice.

H2H: Pumas Came Out on Top in Previous Head-to-Head

Pumas claimed victory in the previous meeting between these teams. A 4-0 home win was registered against Santos at Olimpico Universitario. The previous 10 H2H meetings have seen Santos win six times, one draw and three Pumas triumphs.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
9	Santos Laguna	12	5	1	6	17	16	1	17:16	16
11	Pumas	12	4	4	4	19	20	-1	19:20	16

View Full Table

Santos have 5 wins, 4 losses and 1 draw, averaging 1.5 goals from 5.2 shots on goal and 14.6 attempts. Renato Paiva's team have averaged 51.2% possession and 7.5 corners per game, with their opponents scoring 1.2 goals from 4.8 shots on goal, 15.9 attempts and 5.2 corners.

Top goalscorer Tahiel Jimenez has found the net 5 times, with Ezequiel Bullaude and Fran Villalba scoring 3 and 2 respectively. Mauricio Cuevas and Ezequiel Bullaude have recorded the most assists with 3 apiece.

Pumas UNAM have won 3, lost 3 and drawn 4, with an average of 1.7 goals from 11.2 attempts and 4.4 shots on goal. There’s been an average of 47.4% possession, 5.3 corners in their favour and 4.4 corners against, while they’ve conceded 1.6 goals from 13.0 attempts and 4.1 shots on goal.

Juninho got 8 goals, Robert Morales notched 3, while Cesar Huerta and two other players scored 1. Robert Morales has been the top assist maker with 3 in the last 10 games.

Predicted & Confirmed Lineups

Santos Laguna predicted lineup (3-4-3): Carlos Acevedo Lopez (GK), Franco Pardo, Felipe Sanchez, Efraín Orona, Mauricio Cuevas, Facundo Caseres, Fran Villalba, Emmanuel Echeverria, Ramiro Sordo, Tahiel Jiménez, Ezequiel Bullaude.

Pumas predicted lineup (5-4-1): Keylor Navas (GK), Rodrigo Lopez, Pablo Bennevendo, Nathan Silva, Ruben Duarte, Uriel Antuna, Alan Medina, Adalberto Carrasquilla, Pedro Vite, Juninho, Robert Morales.

Main Match Prediction

Santos Laguna at 0.0 look like an attractive bet on the Asian Handicap for this Liga MX game. Backing the hosts at -141 means a nice return if they win and we think that there’s a strong chance of this happening.

Key stats supporting our main match prediction (league matches):

• The 0.0 line has been covered by Santos in 5 consecutive games.
• The 0.0 line hasn’t been covered by Pumas in 4 of their last 5 games.
• The 0.0 line hasn’t been covered by Pumas in 7 of their last 10 games.
• The 0.0 line has been covered by Santos in 6 of their last 10 games against Pumas.

The Liga MX tipsters at Sportsgambler.com always have a strong handle on team news. A form guide is also utilised for our betting verdict along with checking out the numbers that are going to help inform our final football picks.

The best betting sites make it a 58.5% chance that our pick is settled as a winner. After careful examination, our tipsters calculate this probability to be somewhere between 65-70%. It’s the reason why we are recommending this wager.

There’s often the option to sell goals and that allows you to leverage a bigger potential return. Conversely, buying goals will give you a less-risky bet but shorter odds.

Before placing your wager, explore the best betting offers. Our in-depth bonus guide features a wide range of promotions to choose from.

Santos Asian Hcp 0.0 @ -141 Watch Live Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Oct 20, 05:28). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santos 1 - 0 Pumas

Santos can be backed at +750 to triumph by a 1-0 scoreline. It can be fun to have a wager on the correct score and there’s a big potential return if the bet wins.

Player Prop Picks

Top Pick: Uriel Antuna Over 0.5 Shots On Target +110

Uriel Antuna (Pumas) can be wagered at +110 to record one or more shots on goal. It’s really hard to rule him out at an attractive price for the Shots on Target betting market.

Latest Uriel Antuna Player Prop Odds

Goalscorer

Anytime

+360

First

+1050

Shots On Target

Over 0.5

+115

Under 0.5

-

---

Fran Villalba to Score +330

Fran Villalba (Santos) has netted two goals in his past five Liga MX games. We think this is the pick of the player props, with a generous +330 available when it comes to backing him to score at any time.

Latest Fran Villalba Player Prop Odds

Goalscorer

Anytime

+330

First

+950

Shots On Target

Over 0.5

+102

Under 0.5

-

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Corners Prediction

Santos To Have Most Corners -100

We’ve seen Santos average 8.40 corners in their past 5 home games, with an average 2.40 Pumas corners over the last 10 away matches. Santos look value at -100 to rack up the most corners.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

12.70 7.50 5.20

Home

11.30 6.80 4.50

Away

11.00 5.60 5.40

Pumas

Total

9.70 5.30 4.40

Home

11.00 6.40 4.60

Away

9.30 2.40 6.90

Latest Corner Odds

Total Corners

Over 10.5

-114

Under 10.5

-132

Santos Corners

Over 5.5

+105

Under 5.5

-164

Pumas Corners

Over 4.5

-156

Under 4.5

-100

Most Corners

1

-106

X

+650

2

+107

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santos Laguna vs Pumas Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a 45% prospect of triumphing according to the 1x2 odds, Santos Laguna are favourites to come out on top in this Liga MX clash and they’re available at +120 with the bookmakers. If you want to wager on the underdog, Pumas UNAM have been priced up at +185.

Santos can be backed at +155 on the Half-Time Result and you’ll need them to have their noses in front by the break. Pumas can be chanced at +220 and the draw is +125.

The expectation is that Over 2.5 Goals will be scored according to the latest odds. The Yes pick in the Both Teams to Score market is considered to be the most likely result and it’s trading at -227.

If you head to the best football betting sites, you can take your pick when it comes to Liga MX matches. The hundreds of markets always ensure lots of choice.

Full-Time Result

1

+120

X

+245

2

+185

Half-Time Result

1

+155

X

+125

2

+220

Double Chance

1X

-263

12

-357

X2

-164

Draw No Bet

1

-164

2

+108

Asian Handicap

1 Hcp -0.25

-110

2 Hcp +0.25

-125

Total Goals

Under 2.5

+125

Over 2.5

-175

Both Teams to Score

Yes

-227

No

+148

There’s the chance to back Eduardo Aguirre at +575 to be the First Goalscorer, with the favourite on this market available at similar odds to find the net last.

Eduardo Aguirre (Santos)

First

+575

Anytime

+195

Cesar Huerta (Pumas)

First

+650

Anytime

+200

Juninho (Pumas)

First

+600

Anytime

+210

Esteban Lozano (Santos)

First

+650

Anytime

+220

Robert Morales (Pumas)

First

+700

Anytime

+220

Ezequiel Bullaude (Santos)

First

+700

Anytime

+220

Ramiro Sordo (Santos)

First

+700

Anytime

+230

Diego González (Santos)

First

+800

Anytime

+280

Alan Medina (Pumas)

First

+900

Anytime

+310

Fran Villalba (Santos)

First

+950

Anytime

+330

Uriel Antuna (Pumas)

First

+1050

Anytime

+360

Pedro Vite (Pumas)

First

+1100

Anytime

+370

Luciano Herrera (Pumas)

First

+1200

Anytime

+430

Rodrigo Lopez (Pumas)

First

+1300

Anytime

+450

Salvador Mariscal Murra (Santos)

First

+1300

Anytime

+450

Aldo López (Santos)

First

+1400

Anytime

+500

Javier Güemez (Santos)

First

+1600

Anytime

+525

Adalberto Carrasquilla (Pumas)

First

+1700

Anytime

+575

Álvaro Angulo (Pumas)

First

+1900

Anytime

+650

Emmanuel Echeverria (Santos)

First

+2000

Anytime

+700

Jesus Rivas (Pumas)

First

+2000

Anytime

+700

Efraín Orona (Santos)

First

+2000

Anytime

+750

Santiago Trigos (Pumas)

First

+2200

Anytime

+800

Cristian Calderón (Pumas)

First

+2200

Anytime

+800

Mauricio Cuevas (Santos)

First

+2200

Anytime

+850

Eduardo Aguirre (Santos)

Over 0.5

-182

Under 0.5

-

Robert Morales (Pumas)

Over 0.5

-175

Under 0.5

-

Cesar Huerta (Pumas)

Over 0.5

-175

Under 0.5

-

Juninho (Pumas)

Over 0.5

-172

Under 0.5

-

Ezequiel Bullaude (Santos)

Over 0.5

-159

Under 0.5

-

Esteban Lozano (Santos)

Over 0.5

-154

Under 0.5

-

Ramiro Sordo (Santos)

Over 0.5

-143

Under 0.5

-

Diego González (Santos)

Over 0.5

-118

Under 0.5

-

Luciano Herrera (Pumas)

Over 0.5

-103

Under 0.5

-

Fran Villalba (Santos)

Over 0.5

+102

Under 0.5

-

Alan Medina (Pumas)

Over 0.5

+105

Under 0.5

-

Uriel Antuna (Pumas)

Over 0.5

+115

Under 0.5

-

Pedro Vite (Pumas)

Over 0.5

+120

Under 0.5

-

Salvador Mariscal Murra (Santos)

Over 0.5

+150

Under 0.5

-

Rodrigo Lopez (Pumas)

Over 0.5

+160

Under 0.5

-

Aldo López (Santos)

Over 0.5

+160

Under 0.5

-

Javier Güemez (Santos)

Over 0.5

+190

Under 0.5

-

Adalberto Carrasquilla (Pumas)

Over 0.5

+200

Under 0.5

-

Emmanuel Echeverria (Santos)

Over 0.5

+240

Under 0.5

-

Álvaro Angulo (Pumas)

Over 0.5

+250

Under 0.5

-

Jesus Rivas (Pumas)

Over 0.5

+270

Under 0.5

-

Efraín Orona (Santos)

Over 0.5

+290

Under 0.5

-

Mauricio Cuevas (Santos)

Over 0.5

+320

Under 0.5

-

Stats: Last 10 Liga MX matches only.
Santos Laguna have won each of their last three games at Estadio Nuevo Corona. Los Guerreros have five wins, three losses and two draws in the last 10 home games, scoring an average of 1.40 goals per match and conceding 0.60.

Pumas have secured four wins, three draws and three defeats in the last 10 away matches, scoring an average of 1.50 goals per game and conceding 1.30.

Santos were 3-0 victors against Pumas last time out at Estadio Nuevo Corona. It has been five Santos victories, one Pumas win and two draws in the previous 8 H2H games at Estadio Nuevo Corona.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Santos Laguna Home Stats		5-2-3	2.00	1.40	0.60	4	6	3	7
Pumas Away Stats		4-3-3	2.80	1.50	1.30	5	5	5	5

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Santos Laguna vs Pumas Lineups & Team News

Know who’s in and who’s out for Santos vs Pumas before making your bets. We’ll provide full coverage of predicted and confirmed Liga MX lineups alongside the newest injury information.

Santos Laguna Team Page Pumas Team Page

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