Louisiana vs USC Prediction, Picks & Odds | 12 Sep 2026

College Football Betting Preview: Louisiana vs USC

Louisiana face USC at LA Memorial Coliseum, with kickoff scheduled for 23:00 on Saturday, September 12.

USC and Louisiana are unlikely to reach the 59.5 points line in our opinion. Therefore, chance an Under bet at -112 and hope the teams don’t reach that number.

Louisiana Ragin Cajuns won their previous game, beating Lamar Cardinals at home. It was a 38-7 win at Cajun Field. 

USC Trojans last game was a 39-0 home win. This victory over Fresno State Bulldogs at LA Memorial Coliseum made it back-to-back victories.

Louisiana vs USC Prediction & Picks

Dive into our Louisiana vs USC betting tips, featuring an expert match prediction, our best correct score pick and a ready-made bet builder designed for value.

Game Prediction

59.5 points looks too big a number on the totals and we are therefore happy to play the -112 about Under when it comes to this college football showdown.

The CFB handicappers at Sportsgambler.com always keep close tabs on team news as it develops. We also rely on recent form and key stats to help shape our picks and guide the final call.

Key Louisiana vs USC stats:

• The 59.5 line hasn’t been covered in 4 of the last 5 Louisiana games on the road.
• The 59.5 line hasn’t been covered in 7 of the last 10 Louisiana games.
• The 59.5 line hasn’t been covered in the last 3 Louisiana games.
• The 59.5 line hasn’t been covered in 8 of the last 10 USC games.
• The 59.5 line hasn’t been covered in 4 of the last 5 USC games at home.

Under 59.5 Probability

Looking at the latest betting odds, our pick has a 52.9% chance of winning. However, our analysts have this number closer to 60% based on their in-depth research. This college wager can therefore be backed with confidence.

For a larger payout, many bettors will include their Under wager on the Totals with other selections. A Bet Builder is perfect for combining all your picks.

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Our Game Prediction

Under 59.5 Points @ -112 Bet Now

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Correct Score Prediction

Louisiana 13 - 42 USC

Should you wish to go for a speculative bet, try the Trojans to triumph 42-13 on the correct score lines. This should be a fun wager which could potentially yield a huge return.

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Louisiana vs USC Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

According to the Moneyline betting odds, USC are red-hot -10000 favorites with the sportsbooks and that means a 99% chance of winning this college game. If you’re looking for an alternative angle, Louisiana are trading at +2800.

The spread is 31.5 and the total points line is currently 59.5. Football fans love the chance to get an alternative angle by going for a Total wager. If you want to bet Under 59.5, there are odds of -112.

If you’re getting ready to place a college football bet, head over to one of the top betting apps and explore the wide variety of game lines and team props. Take your time to spot the most appealing opportunities.

Moneyline

Louisiana

+2800

USC

-10000

Point Spread

Louisiana +31.5

-118

USC -31.5

-104

Total Points

Under 59.5

-112

Over 59.5

-108

If you’re looking for an alternative to the main game lines, check out the player props instead. It’s great to bet on Quarterback Passing Yards, First Touchdown Scorer and Passing Touchdowns as potential options.

It’s possible to use stats to your advantage when it comes to college football micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live player, score and team props and see if you can find an angle.

USC Looking to Keep Rolling at Home

USC have recorded nine consecutive victories at LA Memorial Coliseum. They are 9-1 in their last 10 home games, scoring 41.70 points per contest and conceding 20.00.

Louisiana have a 4-6 record in their last 10 road games, putting up 21.90 points per contest and giving up 29.10.

Last 10 Games		W-L	P	PF	PA	O59.5	U59.5
USC Home Stats		9-1	61.70	41.70	20.00	5	5
Louisiana Away Stats		4-6	51.00	21.90	29.10	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O59.5 = Games Over 59.5 Points
• U59.5 = Games Under 59.5 Points

Latest regular season and playoff games stats.

Louisiana Ragin Cajuns Stats

USC Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• +31.5 Betting Line: Have covered the spread in the last 10 games
• +31.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -31.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -31.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 56.60 pts in the previous 10 games
• Game Totals on the Road: An average of 51.00 pts in the previous 10 games on the road
• Over 59.5: Covered in 3 of the previous 10 games
• Over 59.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 28.90 pts and allowed 27.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.90 pts and allowed 29.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.40 pts in the previous 10 games
• Game Totals at Home: An average of 59.90 pts in the previous 10 home games
• Over 59.5: Covered in 2 of the previous 10 games
• Over 59.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 30.40 pts and allowed 21.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 41.70 pts and allowed 18.20 pts in the last 10 home games

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